Pavlovian conditioning alters cortical microtubule-associated protein-2

Woolf, Nancy J.; Young, Stacey L.; Johnson, Gail V.W.; Fanselow, Michael S.

doi:10.1097/00001756-199405000-00007

Cited by 33 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In rats trained to associate a tone with a fear-producing shock, MAP-2 immunohistochemistry was enhanced in cholinoceptive cells con®ned to discrete cytoarchitectonic regions of the auditory cortex (Woolf et al, 1994). In this experiment, MAP-2 changes occurred largely in Te2 and Te3, cytoarchitectonic regions corresponding with association auditory cortex in the rat.…”

Section: Modules In the Cerebral Cortexmentioning

confidence: 50%

“…As will be discussed in Section 4, the biochemical cascade leading to dendritic reorganization may be initiated immediately, as we have observed in the cerebral cortex (Woolf et al, 1994), or it may be delayed for weeks, as we have observed in the hippocampus . Once the process for altering dendrites is initiated, cholinergic input may no longer be necessary.…”

Section: Long-term Memorymentioning

confidence: 58%

“…The functional importance of the cortical module is illustrated in our studies showing memory-related MAP-2 alterations occur in entire sets of cholinoceptive neurons organized within discrete modules of cerebral cortex or discrete sectors of hippocampus (Woolf et al, 1994. Thus, the cholinoceptive cells and their modi®able dendrites that are organized within discrete modules arguably serve as`e ngram units'' in the cortex and hippocampus.…”

Section: Introductionmentioning

confidence: 83%

“…In this experiment, MAP-2 changes occurred largely in Te2 and Te3, cytoarchitectonic regions corresponding with association auditory cortex in the rat. Curiously, the MAP-2 cells in which the immunohistochemical reaction was enhanced had larger somal areas compared to control animals (Woolf et al, 1994). The uniformity of this change made aected Fig.…”

Section: Modules In the Cerebral Cortexmentioning

confidence: 93%

“…The localization of MAP-2 also appears to be related to behavioral conditioning. Pavlovian conditioning and contextual learning alters immunohistochemical reactions for MAP-2 (Woolf et al, 1994. Here we are talking about three relatively small, select cell populations that overlap almost perfectlyÐnamely cells showing conditional electrophysiological adaptation, conditional cytoskeletal protein change, and receptivity to acetylcholine.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A structural basis for memory storage in mammals

Woolf

1998

Progress in Neurobiology

View full text Add to dashboard Cite

AbstractÐIt is proposed that altered dendrite length and de novo formation of new dendrite branches in cholinoceptive cells are responsible for long-term memory storage, a process enabled by the degradation of microtubule-associated protein-2. These memories are encoded as modality-speci®c associable representations. Accordingly, associable representations are con®ned to cytoarchitectonic modules of the cerebral cortex, hippocampus, and amygdala. The proposed sequence of events leading to long-term storage in cholinoceptive dendrites begins with changes in neuronal activity, then in neurotrophin release, followed by enhanced acetylcholine release, muscarinic response, calcium in¯ux, degradation of microtubule-associated protein-2, and ®nally new dendrite structure. Hypothetically, each associable representation consists of altered dendrite segments from approximately 5000±15 000 cholinoceptive cells contained within one or a few module(s). Simultaneous restructuring during consolidation of long-term memory is hypothesized to result in a similar infrastructure among dendrite sets, facilitating co-activation of those dendrite sets by neurotransmitters such as acetylcholine, and conceivably enabling high energy interactions between those dendrites by phenomena such as quantum optical coherence. Based on the speci®c architecture proposed, it is estimated that the human telencephalon contains enough dendrites to encode 50 million associable representations in a lifetime, or put another way, to encode one new associable representation each minute. The implications that this proposal has regarding treatments for Alzheimer's disease are also discussed. #

show abstract

Section: Modules In the Cerebral Cortexmentioning

confidence: 50%

Section: Long-term Memorymentioning

confidence: 58%

Section: Introductionmentioning

confidence: 83%

Section: Modules In the Cerebral Cortexmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations