Paulownia C-geranylated flavonoids: their structural variety, biological activity and application prospects

Cheng, Chun-lei; Jia, Xian-hui; Xiao, Cheng-mei; Tang, Wen-Zhao

doi:10.1007/s11101-019-09614-2

Cited by 26 publications

(15 citation statements)

References 58 publications

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“…The genus Paulownia has been used as a folk remedy, especially in traditional Chinese medicine, and more recently has been considered an interesting source of secondary metabolites, such as flavonoids, lignans, phenolic acids and terpenoids [ 1 ]. Different parts of the tree (bark, fruit, xylem, and leaves) have shown therapeutic properties, mainly due to antioxidant, anti-inflammatory, antimicrobial and anticancer activities [ 2 , 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that the phenolic components with antioxidant properties may be responsible for the observed activity in traditionally used bark extracts [ 5 , 6 , 8 , 9 , 10 ], and they can also be used as chemotaxonomic markers [ 6 ]. Antioxidants can protect from the damage caused by free radicals and can protect lipid-containing food and cosmetic stuffs from oxidation.…”

Section: Introductionmentioning

confidence: 99%

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Pressurized Solvent Extraction of Paulownia Bark Phenolics

2021

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Paulownia bark is mostly utilized jointly with wood, but the possibility of a separate valorization through the pressurized extraction of bark bioactives has been assessed. Subcritical water extraction and supercritical CO2 extraction are green technologies allowing shorter times than conventional solvent extraction under atmospheric shaken conditions. Subcritical water extraction was carried out at temperatures ranging from 140 to 240 °C and supercritical CO2 extraction was performed at different pressures (10, 20 and 30 MPa), temperatures (35, 45 and 55 °C) and ethanol concentrations (0, 10 and 15% (w/w)). Subcritical water extraction under a non-isothermal operation during heating up to 160 °C (19 min) provided extraction yields up to 30%, and the extracts contained up to 7% total phenolics with an ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging capacity equivalent to 35% the activity of Trolox, whereas at 240 °C, the yield decreased to 20%, but the phenolic content reached 21%, and the antiradical activity was equivalent to 85% of Trolox. Supercritical CO2 extraction at 30 MPa, 45 °C and 30 min reached a global yield of 2% after 180 min of extraction, but the product showed very low antiradical capacity. Gallic acid, vanillic acid, vanillin and apigenin were the major phenolic compounds found in the extracts.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pressurized Solvent Extraction of Paulownia Bark Phenolics

2021

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“…The intense blue bands visible in UV after derivatization (especially at Rf = 0.29 and 0.05, Figure 4C) probably came from flavonoid compounds. The leaves of paulownia contain numerous flavonoids, including luteolin, quercetin, apigenin and their derivatives and wide group of C-geranylated flavonoids [32,48]. Among unidentified compounds, particularly interesting was the band with Rf = 0.22, which glowed red in UV light after p-anisaldehyde derivatization.…”

Section: Hptlc Polyphenolic Profile and Verbascoside Quantificationmentioning

confidence: 99%

Antioxidant Activity, Polyphenolic Profiles and Antibacterial Properties of Leaf Extract of Various Paulownia spp. Clones

et al. 2021

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Paulownia spp. are widely distributed ornamental trees with leaves abundant in secondary metabolites of high medicinal potential. Eighteen breeding clones of Paulownia spp. were tested in terms of their antioxidant activity and total polyphenolic contents. The 50% ethanolic extracts (2 g/30 mL) of leaves and petioles were compared in the screening step. Eight paulownia clones were selected for detailed analyses including HPTLC polyphenolic profile, verbascoside content and antibacterial activity against five bacteria species (S. aureus, B. cereus, E. coli, Y. enterocolitica, S. enterica). The species-specific differences in terms of antioxidant activity correlated with phenolic compounds were found mainly in the case of leaf blade extracts, the highest for P. tomentosa × P. fortunei and the lowest for P. elongata × P. fortunei clones. The P. tomentosa clones varied greatly in this regard. In the HPTLC polyphenolic profile, the occurrence of some polyphenols was proved and the specific verbascoside content was quantified (70 to 225 mg/g DW). The P. tomentosa × P. fortunei hybrids had the highest inhibitory activity, mainly against Gram-positive bacteria, whereas only slight inhibition of S. aureus growth was observed for P. elongata × P. fortunei clones. The obtained results indicate diverse suitability of paulownia clones as a source of active ingredients.

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“…A total of twelve C-geranylated flavanones were selected to evaluate their antiviral activity against the SARS-CoV papain-like protease (PLpro). A multitude of viral life cycle phases requires protease enzymes [51]. The majority of the isolated compounds are SARS-CoVPLpro inhibitors.…”

Section: C-geranylated Flavonoids (Tomentin A-e)mentioning

confidence: 99%

Polyphenolic Compounds - A Promising Leads for Antiviral Therapy

Nagarajan¹

2021

Pharmacophore

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Medicinal plants consist of a wide range of phytochemicals, which are usually described as secondary metabolites. The production of secondary metabolites in medicinal plants affects different factors, like stress and defensive responses. Various factors, such as species differences, environmental variables, and so on, will influence the type and level of the presence of secondary metabolites. Phytochemicals are produced by these medicinal plants and have a range of biological effects on human health. Polyphenolic compounds are found throughout the plant kingdom that is highly effective in lowering or minimizing the risk of various chronic illnesses. Polyphenols are classified into two types: flavonoids and phenolic acids. Medicinal plants and plant-based foods have complex mixtures of bioactive polyphenolic compounds. Because of this complexation, we are unable to identify the specific phenolic compounds' health benefits. A variety of scientific publications have explored polyphenolic phytochemicals' biological activity and mechanisms of action. The relevant data were collected from peer-reviewed journals, accessed from different data resources like PubMed, Google Scholar, and Scopus. The current review article focuses on the study of the antiviral properties of polyphenolic compounds.

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Paulownia C-geranylated flavonoids: their structural variety, biological activity and application prospects

Cited by 26 publications

References 58 publications

Pressurized Solvent Extraction of Paulownia Bark Phenolics

Pressurized Solvent Extraction of Paulownia Bark Phenolics

Antioxidant Activity, Polyphenolic Profiles and Antibacterial Properties of Leaf Extract of Various Paulownia spp. Clones

Polyphenolic Compounds - A Promising Leads for Antiviral Therapy

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