Pauci-immune extracapillary glomerulonephritis and atheromatous embolization

Aviles, Beatriz; Ubeda, I; Blanco, Julia; Barrientos, Alberto

doi:10.1053/ajkd.2002.35700

Cited by 10 publications

(7 citation statements)

References 16 publications

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“…In our case, furthermore, the serum level of MPO-ANCA was markedly increased. The association between CES and ANCA, as seen in our case, has only been described in a few cases in the literature (15)(16)(17)(18)(19) …”

Section: Cholesterol Embolization Syndrome (Ces) Is a Systemic Disordmentioning

confidence: 55%

Systemic Cholesterol Embolization Syndrome Associated with Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody

et al. 2006

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Section: Cholesterol Embolization Syndrome (Ces) Is a Systemic Disordmentioning

confidence: 55%

Systemic Cholesterol Embolization Syndrome Associated with Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody

et al. 2006

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“…Cholesterol embolism associated with ANCA has rarely been reported. To date, only 11 cases reported in English could be retrieved from the PubMed database ( ) using the term ‘cholesterol embolism plus ANCA’ ( 9 – 18 ). Clinical characteristics and laboratory findings of these 12 patients (including the present case) are listed in Table I .…”

Section: Discussionmentioning

confidence: 99%

“…In two cases, persistent ANCA and vasculitis developed following cholesterol embolism ( 10 , 16 ). Conversely, in other cases, vasculitis and cholesterol embolism were deemed coexistent, based on the identification of prior medical problems, intense hematuria, variable ANCA titres or a high ANCA titre ( 9 , 13 , 18 ). Notably, the clinical features of cholesterol embolism with ANCA typically resemble those of patients with cholesterol embolism alone ( 3 , 6 ).…”

Section: Discussionmentioning

confidence: 99%

“…Histological confirmation is regarded as the definitive method for the diagnosis of cholesterol embolism, and a renal biopsy was performed for eight of the 12 patients with cholesterol embolism in the literature ( 9 , 11 , 12 , 15 – 17 ). Consistent with previous reports ( 9 , 12 , 17 ), cholesterol emboli were observed in the lumen of the interlobular arteries in the present case, and histological changes to the glomeruli and interstitium were observed. Skin or muscle biopsies were performed for eight of the 12 patients ( 11 – 15 , 17 , 18 ).…”

Section: Discussionmentioning

confidence: 99%

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Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review

Zhang

Chen

et al. 2016

Experimental and Therapeutic Medicine

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Cholesterol embolism is a multisystemic disorder with clinical manifestations that resemble vasculitis. Anti-neutrophil cytoplasmic antibodies (ANCA) are a defining feature of ANCA-associated vasculitis, and the presence of ANCA in cholesterol embolism complicates its differential diagnosis and treatment. At present, the role of ANCA in cholesterol embolism remains unclear and no effective treatment is currently available. The present study reports the case of an Asian male who presented with spontaneous cholesterol embolism with proteinase 3 (PR3)-specific ANCA, subacute interstitial nephritis and late-developing skin lesions. The 69-year-old patient was admitted to The First Affiliated Hospital of Xiamen University (Xiamen, China) complaining of chest tightness, fatigue, progressive renal failure and refractory hypertension. In addition, transient eosinophilia was detected. Following immunosuppressive therapy with steroids and cyclophosphamide for 6 months, hemodialysis treatment was initiated. Skin lesions appeared at >1 month following hemodialysis initiation; however, they were gradually improved following treatment with atorvastatin and anti-platelet aggregation therapy for 5 months. The patient was maintained on hemodialysis for ~2 years and exhibited general good health at the most recent follow-up. In addition, 11 cases of cholesterol embolism associated with ANCA reported in the literature were discussed in the present study.

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“…Although the pathological diagnosis was cholesterol embolism, they continued to treat him with glucocorticoid and cyclophosphamide with a favorable outcome. Aviles et al reported a case of cholesterol microemboli who also developed extracapillary glomerulonephritis in the presence of P-ANCA which is the hallmark of ANCA-related vasculitis (3). Delen et al reported a 65-year-old woman with systemic inflammatory signs and renovascular hypertension due to atherosclerotic narrowing of both renal arteries (4).…”

Section: Much Attention Has Been Given To Microscopic Polyangiitis (Mmentioning

confidence: 99%

ANCA in Atheroembolism; Just a Coincidence or Bearing Cause and Effect?

Minota

2006

Intern. Med.

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Pauci-immune extracapillary glomerulonephritis and atheromatous embolization

Cited by 10 publications

References 16 publications

Systemic Cholesterol Embolization Syndrome Associated with Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody

Systemic Cholesterol Embolization Syndrome Associated with Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody

Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review

ANCA in Atheroembolism; Just a Coincidence or Bearing Cause and Effect?

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