Patterns of Spontaneous Magnetoencephalographic Activity in Patients With Schizophrenia

Siekmeier, Peter J.; Stufflebeam, Steven M.

doi:10.1097/wnp.0b013e3181e0b20a

Cited by 48 publications

(45 citation statements)

References 101 publications

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“…9 A recent review of MEG studies of spontaneous activity revealed converging evidence of increased theta and delta oscillations in subjects with schizophrenia, most prominent in the temporal lobe. 20 Like other frequencies, contradictory and negative findings exist. For example, in sleep, unmedicated schizophrenia patients showed reduced delta/theta power.…”

Section: Is There a Critical Frequency Linked To Schizophrenia?mentioning

confidence: 95%

High vs Low Frequency Neural Oscillations in Schizophrenia

Moran

Hong

2011

Schizophrenia Bulletin

195

137

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There is growing recognition that neural oscillations are important in a wide range of perceptual and cognitive functions. One of the key issues in electrophysiological studies of schizophrenia is whether high or low frequency oscillations, or both, are related to schizophrenia because many brain functions are modulated with frequency specificities. Many recent electrophysiological studies of schizophrenia have focused on high frequency oscillations at gamma band and in general support gamma band dysfunction in schizophrenia. We discuss the concept that gamma oscillation abnormalities in schizophrenia often occur in the background of oscillation abnormalities of lower frequencies. The review discusses the basic neurobiology for the emergence of oscillations of all frequency bands in association with networks of inhibitory interneurons and the convergence and divergence of such mechanisms in generating high vs low frequency oscillations. We then review the literature of oscillatory frequency abnormalities identified in each frequency band in schizophrenia. By describing some of the key functional roles exerted by gamma, low frequencies, and their cross-frequency coupling, we conceptualize that even isolated alterations in gamma or low frequency oscillations may impact the interactions of high and low frequency bands that are involved in key cognitive functions. The review concludes that studying the full spectrum and the interaction of gamma and low frequency oscillations may be critical for deciphering the complex electrophysiological abnormalities observed in schizophrenia patients.Key words: oscillation/schizophrenia/gamma/theta Overview Neural oscillations are electrical activities of the brain measurable at different frequencies. They are typically described as low frequency bands at delta (<4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and beta (12-30 Hz) to high frequencies at gamma band that spans from roughly gamma (30-80 Hz) to high gamma (>80 Hz). These oscillatory activities can be obtained at many levels, ranging from single cell to local field potentials in animals, to large-scale synchronized activities in human scalp. Patients with schizophrenia exhibit impaired neural oscillatory activities during sensory and cognitive tasks. One of the oldest but also reemerging debates in electrophysiology is what is the key frequency relevant to the pathophysiology of schizophrenia, given that abnormalities of neural oscillations are found essentially in all frequency bands in schizophrenia patients. Research into the specificity of frequency abnormality, if found, could provide key biological markers linking disease mechanism to the clinical dysfunctions in schizophrenia.Many known brain functions are associated with electrical activities at specific frequencies. Recent event-related potential (ERP) studies of schizophrenia have focused on gamma band because of its critical role in cognitive functions 1 and in general support gamma band reduction in schizophrenia. 2,3 In comparison, earlier electroencephalographic ...

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Section: Is There a Critical Frequency Linked To Schizophrenia?mentioning

confidence: 95%

High vs Low Frequency Neural Oscillations in Schizophrenia

Moran

Hong

2011

Schizophrenia Bulletin

195

137

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“…According to recent evidence, magnetoencephalography activity enables to describe identifiable patterns, and it has been documented that schizophrenic patients have increased θ (4-8 Hz) and δ (1-4 Hz) band oscillations in the temporal lobes (Siekmeier and Stufflebeam, 2010). Based on these findings, Siekmeier and Stufflebeam (2010) recently documented that in eight of the 10 studies, a positive Brought to you by | New York University Bobst Library Technical Services Authenticated Download Date | 5/27/15 8:53 PM correlation between temporal lobe θ activity and positive schizophrenic symptoms has been found.…”

Section: Common Aspects Of Neural Mechanisms Of Consciousness and Schmentioning

confidence: 99%

Consciousness, awareness of insight and neural mechanisms of schizophrenia

Touskova

Bob²

2015

Reviews in the Neurosciences

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AbstractAccording to recent research, disturbances of self-awareness and conscious experience have a critical role in the pathophysiology of schizophrenia, and in this context, schizophrenia is currently understood as a disorder characterized by distortions of acts of awareness, self-consciousness, and self-monitoring. Together, these studies suggest that the processes of disrupted awareness and conscious disintegration in schizophrenia might be related and represented by similar disruptions on the brain level, which, in principle, could be explained by various levels of disturbed connectivity and information disintegration that may negatively affect usual patterns of synchronous activity constituting adaptive integrative functions of consciousness. On the other hand, mental integration based on self-awareness and insight may significantly increase information integration and directly influence neural mechanisms underlying basic pathophysiological processes in schizophrenia.

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“…A meta-analysis of data suggested that elevations in power of lower EEG frequencies during wakefulness (theta and delta band activity, 1–8 Hz) are a more robust electrophysiological marker for schizophrenia [30], a suggestion that fits well with the overt deficits in related sleep structure [31]. However, the literature is again equivocal.…”

Section: Changes In Theta and Delta Rhythms In Schizophreniamentioning

confidence: 99%

Aberrant Network Activity in Schizophrenia

Hunt

Kopell

Traub

et al. 2017

Trends in Neurosciences

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Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely equivocal, but stronger for lower (delta) than for higher (gamma) bands. However, region-specific changes in rhythms across multiple, interdependent, nested frequencies may correlate better with pathology. Changes in synaptic excitation and inhibition in schizophrenia disrupt delta rhythm-mediated cortico-cortical communication, while enhancing thalamo-cortical communication in this frequency band. The contrasting relationships between delta and higher frequencies in thalamus and cortex generate frequency mismatches in inter-regional connectivity, leading to a disruption in temporal communication between higher-order brain regions associated with mental time travel.

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Patterns of Spontaneous Magnetoencephalographic Activity in Patients With Schizophrenia

Cited by 48 publications

References 101 publications

High vs Low Frequency Neural Oscillations in Schizophrenia

High vs Low Frequency Neural Oscillations in Schizophrenia

Consciousness, awareness of insight and neural mechanisms of schizophrenia

Aberrant Network Activity in Schizophrenia

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