Patterns of sensory modulation by age and sex in young people on the autism spectrum

Lane, Alison E.; Simpson, Kate; Masi, Anne; Grove, Rachel; Moni, Mohammad Ali; Montgomery, Alicia; Roberts, Jacqui; Silove, Natalie; Whalen, Olivia M.; Whitehouse, Andrew; Eapen, Valsamma

doi:10.1002/aur.2762

Cited by 14 publications

(8 citation statements)

References 33 publications

(79 reference statements)

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“…This hyper‐sensitivity profile was previously associated with the severity of expressive language deficit (Rossow et al, 2022) but also with early stages of their developmental trajectory (Ben‐Sasson et al, 2019; Green et al, 2012)—as we reported both in the PARIS and the LEAP samples. In our study, we reported a significant positive interaction (i.e., in favor of hyper‐sensitivity) between dSSP score and chronological age of the participants, which is coherent with the literature (Lane et al, 2022), with a dSSP score stability across child development described by repeated measures on the PARIS study. Although the sensory differences appear early in the development, the dSSP stability appears as a good biomarker candidate of autism spectrum (Aronson & Ferner, 2017; Baranek et al, 2013; Estes et al, 2015; O Miguel et al, 2017).…”

Section: Discussionsupporting

confidence: 92%

Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways

et al. 2022

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As an integral part of autism spectrum symptoms, sensory processing issues including both hypo and hyper sensory sensitivities. These sensory specificities may result from an excitation/inhibition imbalance with a poorly understood of their level of convergence with genetic alterations in GABA‐ergic and glutamatergic pathways. In our study, we aimed to characterize the hypo/hyper‐sensory profile among autistic individuals. We then explored its link with the burden of deleterious mutations in a subset of individuals with available whole‐genome sequencing data. To characterize the hypo/hyper‐sensory profile, the differential Short Sensory Profile (dSSP) was defined as a normalized and centralized hypo/hypersensitivity ratio from the Short Sensory Profile (SSP). Including 1136 participants (533 autistic individuals, 210 first‐degree relatives, and 267 controls) from two independent study samples (PARIS and LEAP), we observed a statistically significant dSSP mean difference between autistic individuals and controls, driven mostly by a high dSSP variability, with an intermediated profile represented by relatives. Our genetic analysis tended to associate the dSSP and the hyposensitivity with mutations of the GABAergic pathway. The major limitation was the dSSP difficulty to discriminate subjects with a similar quantum of hypo‐ and hyper‐sensory symptoms to those with no such symptoms, resulting both in a similar ratio score of 0. However, the dSSP could be a relevant clinical score, and combined with additional sensory descriptions, genetics and endophenotypic substrates, will improve the exploration of the underlying neurobiological mechanisms of sensory processing differences in autism spectrum.

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Section: Discussionsupporting

confidence: 92%

Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways

et al. 2022

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“…Notably, these response patterns are not mutually exclusive, and many individuals express behaviors characteristic of multiple sensory response patterns, even within the same modality. Sensory reactivity differences are extremely common in autistic individuals: the point prevalence of a child displaying differences in any of the three response patterns (i.e., HYPER, HYPO, or SEEK in any modality) was recently estimated to be 74% using large-scale population-based data from the Autism and Developmental Disabilities Monitoring Network (18), and 70.9-88.3% of autistic youth in two large samples (from the United States and Australia, respectively) were determined to have sensory reactivity differences of at least "mild" severity (19,20).…”

Section: Introductionmentioning

confidence: 99%

Examining the Latent Structure and Correlates of Sensory Reactivity in Autism: A Multi-site Integrative Data Analysis by the Autism Sensory Research Consortium

Williams

Schaaf

Ausderau

et al. 2023

Preprint

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Background Differences in responding to sensory stimuli, including sensory hyperreactivity (HYPER), hyporeactivity (HYPO), and sensory seeking (SEEK) have been observed in autistic individuals across sensory modalities, but few studies have examined the structure of these “supra-modal” traits in the autistic population. Methods Leveraging a combined sample of 3,868 autistic youth drawn from 12 distinct data sources (ages 3–18 years and representing the full range of cognitive ability), the current study used modern psychometric and meta-analytic techniques to interrogate the latent structure and correlates of caregiver-reported HYPER, HYPO, and SEEK within and across sensory modalities. Bifactor statistical indices were used to both evaluate the strength of a “general response pattern” factor for each supra-modal construct and determine the added value of “modality-specific response pattern” scores (e.g., Visual HYPER). Bayesian random-effects integrative data analysis models were used to examine the clinical and demographic correlates of all interpretable HYPER, HYPO and SEEK (sub)constructs. Results All modality-specific HYPER subconstructs could be reliably and validly measured, whereas certain modality-specific HYPO and SEEK subconstructs were psychometrically inadequate when measured using existing items. Bifactor analyses unambiguously supported the validity of a supra-modal HYPER construct (ωH = .800), whereas a coherent supra-modal HYPO construct was not supported (ωH = .611), and supra-modal SEEK models suggested a more limited version of the construct that excluded some sensory modalities (ωH = .799; 4/7 modalities). Within each sensory construct, modality-specific subscales demonstrated substantial added value beyond the supra-modal score. Meta-analytic correlations varied by construct, although sensory features tended to correlate most strongly with other domains of core autism features and co-occurring psychiatric symptoms. Certain subconstructs within the HYPO and SEEK domains were also associated with lower adaptive behavior scores. Limitations: Conclusions may not be generalizable beyond the specific pool of items used in the current study, which was limited to parent-report of observable behaviors and excluded multisensory items that reflect many “real-world” sensory experiences. Conclusion Psychometric issues may limit the degree to which some measures of supra-modal HYPO/SEEK can be interpreted. Depending on the research question at hand, modality-specific response pattern scores may represent a valid alternative method of characterizing sensory reactivity in autism.

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“…One issue is training dentists to distinguish the different spectra of ASD, i.e., whether classical autism or Asperger syndrome (299.00 DSM-IV), atypical autism (pervasive developmental disorder not otherwise specified, 299.80 DSM-IV), or Rett syndrome or more simply a non-autistic cognitive disorder ( 62 ). In addition, awareness of the existence of specific sensory modulation subtypes in autistic children, by sex and age, is crucial to address these patients appropriately ( 63 ).…”

Section: Oral Health Prevention In the Autistic Subject As Early As P...mentioning

confidence: 99%

Insights on dental care management and prevention in children with autism spectrum disorder (ASD). What is new?

Zerman

Zotti²,

Chirumbolo³

et al. 2022

Front. Oral. Health

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Autistic subjects represent a severe concern to dentistry due to the considerable difficulty in managing their oral health, maintaining routine toothbrushing, and preventing dental and periodontal problems. The social and economic burden of managing dental care in autism spectrum disorder (ASD) children is particularly cumbersome for families and public and private health expenditure, especially when children reach the dentist following a late diagnosis with evident oral health problems. An early diagnosis of ASD helps dentists better address these children's oral health. Unfortunately, insufficient attention is paid to the training and education of general pediatricians, dentists, and dental hygienists, allowing them to get to approach the different clinical aspects of ASD. Usually, children diagnosed with ASD are scheduled for dental appointments like their neurotypical peers, whereas their needs are typically complex and personalized. Scant attention is also devoted to these patients by commercial manufacturers of dental products and devices for oral hygiene and prevention of caries and periodontal diseases, leaving parents without the support and often failing when they address the oral health of autistic children. The difficulties of oral care do not derive simply from the behavior of ASD patients, as is commonly assumed, and therefore cannot be overcome solely by the patience and attention of parents and dentists. Genetics, dietary habits, sensory impairments, and cognition disorders are other causes contributing in various degrees to the impact on the mood and psychological reactions of autistic children towards dentists. How can we prevent teeth caries, periodontal disorders, and other oral health impairments by properly managing ASD children? This manuscript gives an up-to-date overview of these problems and helps to provide good remarks.

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Patterns of sensory modulation by age and sex in young people on the autism spectrum

Cited by 14 publications

References 33 publications

Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways

Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways

Examining the Latent Structure and Correlates of Sensory Reactivity in Autism: A Multi-site Integrative Data Analysis by the Autism Sensory Research Consortium

Insights on dental care management and prevention in children with autism spectrum disorder (ASD). What is new?

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