Patterns of resting state connectivity in human primary visual cortical areas: A 7T fMRI study

Raemaekers, Mathijs; Schellekens, Wouter; Wezel, Richard van; Petridou, Natalia; Kristo, Gert; Ramsey, Nick F.

doi:10.1016/j.neuroimage.2013.09.060

Cited by 58 publications

(86 citation statements)

References 55 publications

(57 reference statements)

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“…The parietal and frontal cortices are typically considered to be higher‐order regions, and their function may be more defined by areas higher up the sensory hierarchy (e.g., V3 or planum temporale) than areas within Heschl's gyrus and the intracalcarine sulcus. In resting state FC, visual regions V1, V2, and V3 typically show correlated activity [Raemaekers et al, 2014; Smith et al, 2004; Yeo et al, 2011]. Thus, the functional results observed are unlikely to be a consequence of the choice of ROIs.…”

Section: Discussionmentioning

confidence: 99%

Auditory and visual connectivity gradients in frontoparietal cortex

Braga

Hellyer

Wise

et al. 2016

Human Brain Mapping

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A frontoparietal network of brain regions is often implicated in both auditory and visual information processing. Although it is possible that the same set of multimodal regions subserves both modalities, there is increasing evidence that there is a differentiation of sensory function within frontoparietal cortex. Magnetic resonance imaging (MRI) in humans was used to investigate whether different frontoparietal regions showed intrinsic biases in connectivity with visual or auditory modalities. Structural connectivity was assessed with diffusion tractography and functional connectivity was tested using functional MRI. A dorsal–ventral gradient of function was observed, where connectivity with visual cortex dominates dorsal frontal and parietal connections, while connectivity with auditory cortex dominates ventral frontal and parietal regions. A gradient was also observed along the posterior–anterior axis, although in opposite directions in prefrontal and parietal cortices. The results suggest that the location of neural activity within frontoparietal cortex may be influenced by these intrinsic biases toward visual and auditory processing. Thus, the location of activity in frontoparietal cortex may be influenced as much by stimulus modality as the cognitive demands of a task. It was concluded that stimulus modality was spatially encoded throughout frontal and parietal cortices, and was speculated that such an arrangement allows for top–down modulation of modality‐specific information to occur within higher‐order cortex. This could provide a potentially faster and more efficient pathway by which top–down selection between sensory modalities could occur, by constraining modulations to within frontal and parietal regions, rather than long‐range connections to sensory cortices. Hum Brain Mapp 38:255–270, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Auditory and visual connectivity gradients in frontoparietal cortex

Braga

Hellyer

Wise

et al. 2016

Human Brain Mapping

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“…Prior work has shown that the 10 V1-V3 maps have highly regular topography and are well aligned to measures of anatomy, such as 11 surface curvature (Hinds et al, 2008;Benson et al, 2012;2014) and myelination (Abdollahi et al, 2014), 12 and to measures of function such as resting-state connectivity (Raemaekers et al, 2014; Bock et al, 13 2015). Therefore, these maps are likely to be well aligned across subjects, and averaging will preserve 14 many of the retinotopic features found in the maps of individual subjects.…”

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confidence: 95%

“…(B) pRF model solutions. We solved pRF models for 181 10 individual subjects and 3 group-average pseudo-subjects (the average of split-halves of 11 the subjects or of all subjects). For each of the 184 subjects, 3 types of models were fit: 12 one reflecting the complete set of runs and two reflecting split-halves of the runs.…”

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confidence: 99%

“…They are in scene file: 6 7 Retinotopy_HCP_7T_181_fsaverage.scene: https://balsa.wustl.edu/sceneFile/show/281D 8 9 Mean curvature for fsaverage vs MSMAll. Figure S9 shows maps of mean curvature (folding) 10 computed from the fsaverage atlas (column 1) and the average across the 181 7T retinotopy 11 subjects aligned using MSMAll (column 2). Columns 3 and 4 show the same maps binarized for 12 positive (gyral) vs negative (sulcal) average folding values.…”

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confidence: 99%

“…The other was an adaptive barycentric method, which is inherently smoother. 10 However, for the polar angle and eccentricity maps, we first converted to Euclidean coordinates, 11 in order to avoid discontinuities arising solely from representation, followed by adaptive 12 barycentric area resampling, then conversion back into polar angle and eccentricity. 13 14 Note that the fsaverage datasets are much larger (and slower to load) because they were 15 upsampled to the 164k FreeSurfer mesh, rather than the fs_LR 32k mesh in which the 16 retinotopy analyses were carried out.…”

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confidence: 99%

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The HCP 7T Retinotopy Dataset: Description and pRF Analysis

Benson

Arcaro

et al. 2018

Preprint

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About a quarter of human cerebral cortex is tiled with maps of the visual field. These maps can be 3 measured with functional magnetic resonance imaging (fMRI) while subjects view spatially modulated 4 visual stimuli, also known as 'retinotopic mapping'. One of the datasets collected by the Human 5Connectome Project (HCP) involved ultra-high-field (7 Tesla) fMRI retinotopic mapping in 181 healthy 6 adults (1.6-mm resolution), yielding the largest freely available collection of retinotopy data. Here, we 7 describe the experimental paradigm and the results of model-based analysis of the fMRI data. These 8 results provide estimates of population receptive field position and size. Our analyses include both results 9 from individual subjects as well as results obtained by averaging fMRI time-series across subjects at each 10 cortical and subcortical location and then fitting models. Both the group-average and individual-subject 11 results reveal robust signals across much of the brain, including occipital, temporal, parietal, and frontal 12 cortex as well as subcortical areas. The group-average results agree well with previously published 13 parcellations of visual areas. In addition, split-half analyses demonstrate strong within-subject reliability, 14 further evidencing the high quality of the data. We make publicly available the analysis results for 15 individual subjects and the group average, as well as associated stimuli and analysis code. These 16 resources provide an opportunity for studying fine-scale individual variability in cortical and subcortical 17 organization and the properties of high-resolution fMRI. In addition, they provide a measure that can be 18 combined with other HCP measures acquired in these same participants. This enables comparisons 19 across groups, health, and age, and comparison of organization derived from a retinotopic task against 20 that derived from other measurements such as diffusion imaging and resting-state functional connectivity. 21 22. CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/308247 doi: bioRxiv preprint first posted online Apr. 25, 2018; 3 Introduction 1 2The central nervous system maps sensory inputs onto topographically organized representations. In the 3 field of vision, researchers have successfully exploited functional magnetic resonance imaging (fMRI) to 4 noninvasively measure visual field representations ('retinotopy') in the living human brain (Engel et al., 5 1994;Sereno et al., 1995; DeYoe et al., 1996; Engel et al., 1997). These efforts enable parcellation of 6 visual cortex into distinct maps of the visual field, thereby laying the foundation for detailed investigations 7 of the properties of visual cortex (parcellation references: Abdollahi et al., 2014;Benson et al., 2014; 8 Wang et al., 2015; review references: Tootell et al., 1996;Wandell et...

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LSD alters eyes‐closed functional connectivity within the early visual cortex in a retinotopic fashion

Roseman

Sereno²,

Leech

et al. 2016

Human Brain Mapping

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The question of how spatially organized activity in the visual cortex behaves during eyes-closed, lysergic acid diethylamide (LSD)-induced "psychedelic imagery" (e.g., visions of geometric patterns and more complex phenomena) has never been empirically addressed, although it has been proposed that under psychedelics, with eyes-closed, the brain may function "as if" there is visual input when there is none. In this work, resting-state functional connectivity (RSFC) data was analyzed from 10 healthy subjects under the influence of LSD and, separately, placebo. It was suspected that eyes-closed psychedelic imagery might involve transient local retinotopic activation, of the sort typically associated with visual stimulation. To test this, it was hypothesized that, under LSD, patches of the visual cortex with congruent retinotopic representations would show greater RSFC than incongruent patches. Using a retinotopic localizer performed during a nondrug baseline condition, nonadjacent patches of V1 and V3 that represent the vertical or the horizontal meridians of the visual field were identified. Subsequently, RSFC between V1 and V3 was measured with respect to these a priori identified patches. Consistent with our prior hypothesis, the difference between RSFC of patches with congruent retinotopic specificity (horizontal-horizontal and vertical-vertical) and those with incongruent specificity (horizontal-vertical and vertical-horizontal) increased significantly under LSD relative to placebo, suggesting that activity within the visual cortex becomes more dependent on its intrinsic retinotopic organization in the drug condition. This result may indicate that under LSD, with eyes-closed, the early visual system behaves as if it were seeing spatially localized visual inputs. Hum Brain Mapp 37:3031-3040, 2016. © 2016 Wiley Periodicals, Inc.

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Patterns of resting state connectivity in human primary visual cortical areas: A 7T fMRI study

Cited by 58 publications

References 55 publications

Auditory and visual connectivity gradients in frontoparietal cortex

Auditory and visual connectivity gradients in frontoparietal cortex

The HCP 7T Retinotopy Dataset: Description and pRF Analysis

LSD alters eyes‐closed functional connectivity within the early visual cortex in a retinotopic fashion

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