Patterns of remission in pemphigus vulgaris

Herbst, Andrew; Bystryn, Jean‐Claude

doi:10.1016/s0190-9622(00)90213-5

Cited by 168 publications

(163 citation statements)

References 9 publications

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“…The proportion of evaluable patients in complete remission was 33% and 75% respectively. The remaining patients were in partial remissions controlled with only an adjuvant which is similar to Andrew Herbst et al [8].…”

Section: Discussionsupporting

confidence: 53%

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A preliminary study on clinical outcome of corticosteroid therapy in pemphigus patients

Vijayakumar¹,

P²,

Sasikala³

et al. 2014

Our Dermatol Online

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Introduction: Pemphigus is life threating blistering of autoimmune disease of the skin and mucous membrane characterised by autoantibodies (auto ABs) against desmoglein-3 (DSG-3). Desmosomal adhesions, protein expressed on the surface of epidermal keratinocytes. Aim: The present study was to assess the incidence rate of pemphigus, to evaluate the clinical course along with clinical manifestations, Complications and Metabolic factors of patients with pemphigus and to investigate the disease severity and induction of remission during the clinical course and whereas to assess the oxidative stress and antioxidant status in pemphigus patients in our hospital. Material and Methods: A prospective study was conducted over a period of January 2012 to December 2012 at dermatology department, MGM Hospital, Warangal. The data was collected from 32 cases of Pemphigus on the basis of Age, Sex, Social Habits, BMI, Histopathological forms, Clinical manifestations and Drug therapy. This hospital is 1200 bedded government hospital provided Outpatient and Inpatient care for Indian citizen especially in Telangana region free of cost. Results: Of the 32 pemphigus patients, 75% were diagnosed with Pemphigus Vulgaris (PV), 12.5% with Pemphigus Foliaceus (PF) and 12.5% with Bullous Pemphigoid (BP). The male to female ratio was approximately 1:1.3. The mean age of onset was 40.8 years in Pemphigus patients. The Onset of disease was 29.85. 34% of patients with Pemphigus had both the mucosal and skin involvement during the clinical course while 25% at the onset of disease. The most common complication was found to be increase blood sugar (40%). Most commonly prescribed adjuvant is dapsone. Majority attained the complete remission and remaining of them attains partial remission. Oxidative stress levels were higher and antioxidant status levels were lower in study subjects when compared to controls. Conclusions: PV is the most common subtype of Pemphigus in our Hospital and usually affects females more than males. Our study reveals that mucosal and skin involvement is common. Corticosteroids and dapsone as adjuvant is majorly prescribed. Most of patients attain complete remission and remaining of them achieves partial remission. Oxidative stress levels were higher and antioxidant status levels were lower in our study subjects when compared to controls.

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Section: Discussionsupporting

confidence: 53%

“…The Glutathione is endogenous antioxidant; it forms a coloured complex with DTNB, which is measured spectrophotometrically [5,6]. For the estimation of total antioxidant status, we used a stable free radical-diphenyl-picryl hydrazyl (DPPH) at the concentration of 0.2mM in methanol [7,8].…”

Section: Methodsmentioning

confidence: 99%

A preliminary study on clinical outcome of corticosteroid therapy in pemphigus patients

Vijayakumar¹,

P²,

Sasikala³

et al. 2014

Our Dermatol Online

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“…4 PV patients represent a heterogeneous population with regard to the natural course of their disease, clinical features, and response to therapy, perhaps due to dramatic patient-to-patient variations in the immunopathological mechanisms. [5][6][7][8] Apoptosis is believed to play a role in the mechanism of keratinocyte death in PV. The occurrence of apoptosis markers has been observed in early lesions of PV patients before acantholysis.…”

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confidence: 99%

Novel Mechanisms of Target Cell Death and Survival and of Therapeutic Action of IVIg in Pemphigus

Arredondo

Chernyavsky

Karaouni

et al. 2005

The American Journal of Pathology

112

139

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“…Systemic administration of CH allows for establishing control of acantholysis in the skin and oral mucosa of the patient during the acute stage of the disease (6 -8). The mortality rate now is at 5-15% (9,10), and death is almost invariably due to the complications of glucocorticosteroid therapy (11)(12)(13). Thus, although modern treatment of pemphigus with CH is lifesaving, the patients suffer from severe side effects and complications.…”

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confidence: 99%

Pemphigus Vulgaris IgG and Methylprednisolone Exhibit Reciprocal Effects on Keratinocytes

Nguyen

Arredondo

Chernyavsky

et al. 2004

Journal of Biological Chemistry

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Patterns of remission in pemphigus vulgaris

Cited by 168 publications

References 9 publications

A preliminary study on clinical outcome of corticosteroid therapy in pemphigus patients

A preliminary study on clinical outcome of corticosteroid therapy in pemphigus patients

Novel Mechanisms of Target Cell Death and Survival and of Therapeutic Action of IVIg in Pemphigus

Pemphigus Vulgaris IgG and Methylprednisolone Exhibit Reciprocal Effects on Keratinocytes

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