Patterns of recurrence and outcome in patients with surgically resected small cell lung cancer

Abstract

Our retrospective study suggested that PCI might have a role in surgically resected patients with p-stage II/III SCLC because of their relatively high frequency of brain metastasis.

Prophylactic Cranial Irradiation for Patients with Surgically Resected Small Cell Lung Cancer

“…19 Similarly, the high frequency of BM in surgically resected patients with pstage II/III SCLC might explain the superior survival benefits of PCI therapy in this population. 20 Previously, a multi-institutional prospective study (JCOG9101) reported that the incidence of BM was 15% (nine of 61) in patients with surgically resected SCLC and only 11% (four of 35) in patients with p-stage I disease, but it was 19.2% in patients with p-stage II/III disease. 21 Similar results were also achieved in a retrospective study that evaluated the factors affecting the risk for BM in patients with SCLC with surgery.…”

Effect of Chemotherapy in Patients With Resected Small-Cell or Large-Cell Neuroendocrine Carcinoma

“…The use of adjuvant mediastinal radiotherapy may improve OS, as is the case for patients treated with combined chemoradiotherapy. 7,10,34 The use of PCI did not affect the results of our sensitivity analysis because results were similar if patients who received PCI were excluded from the analysis.…”

Efficacy of surgery and prophylactic cranial irradiation in stage II and III small cell lung cancer

“…However, few studies have investigated the value of PCI for resected disease. Several scholars have retrospectively assessed the risk of brain relapse after surgery for limited SCLC, suggesting that PCI might have a role in surgically resected stages (p-stage) II and III patients because of their relatively high frequency of brain metastasis, but not for stage (p-stage) I disease due to lower incidence of brain metastases 22 - 25 , 31 - 32 . In the present study, PCI was considered to be an independent prognostic factor for OS.…”

“…However, few studies have assessed the use of PCI for resected SCLC. Several retrospective studies have investigated the risk of brain metastasis according to the stage, but showed inconsistent results 21 - 25 . The value of PCI in this population needs further investigation.…”