Patterns of prefrontal dysfunction in alcoholics with and without Korsakoff's syndrome, patients with Parkinson's disease, and patients with rupture and repair of the anterior communicating artery

Dirksen, Courtney L; Howard, Julie A.; Cronin‐Golomb, Alice; Oscar‐Berman, Marlene

doi:10.2147/nedt.2006.2.3.327

Cited by 43 publications

(45 citation statements)

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“…Frontal lobe structure and function Although alcoholismrelated cortical changes have been documented throughout the brain, many studies consistently have found the frontal lobes to be more vulnerable to alcohol-related brain damage than other cerebral regions (Dirksen et al 2006;Gansler et al 2000;Gilman et al 1996;Oscar-Berman et al 2004;Pfefferbaum et al 1997;Ratti et al 2002). Neuropathological studies performed on the brains of deceased patients have revealed decreased neuron density in the frontal cortex of alcoholics (Harper and Matsumoto 2005).…”

Section: Neural Systems Affected and Concomitant Neurobehavioral Defimentioning

confidence: 99%

“…Prefrontal neurobehavioral dysfunction has been frequently observed in alcoholics with and without the dense amnesia of Korsakoff's syndrome (Dirksen et al 2006;Gansler et al 2000;OscarBerman et al 2004). In two recent studies (Dirksen et al 2006;Oscar-Berman et al 2004), we administered a series of neuropsychological tasks sensitive to dysfunction of frontal brain systems to abstinent alcoholics, including groups of patients with Korsakoff's syndrome.…”

Section: Neural Systems Affected and Concomitant Neurobehavioral Defimentioning

confidence: 99%

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Alcohol: Effects on Neurobehavioral Functions and the Brain

2007

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Alcoholism results from an interplay between genetic and environmental factors, and is linked to brain defects and associated cognitive, emotional, and behavioral impairments. A confluence of findings from neuroimaging, physiological, neuropathological, and neuropsychological studies of alcoholics indicate that the frontal lobes, limbic system, and cerebellum are particularly vulnerable to damage and dysfunction. An integrative approach employing a variety of neuroscientific technologies is essential for recognizing the interconnectivity of the different functional systems affected by alcoholism. In that way, relevant experimental techniques can be applied to assist in determining the degree to which abstinence and treatment contribute to the reversal of atrophy and dysfunction.

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Section: Neural Systems Affected and Concomitant Neurobehavioral Defimentioning

confidence: 99%

Section: Neural Systems Affected and Concomitant Neurobehavioral Defimentioning

confidence: 99%

Alcohol: Effects on Neurobehavioral Functions and the Brain

2007

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“…The ACC and parietal cortex are part of a distributed network that underlies cognitive control, conflict monitoring, effortful processing, and impulse control (Botvinick et al, 1999(Botvinick et al, , 2001Luu and Pederson, 2004;Ridderinkhof et al, 2004;Aron et al, 2004;Jentsch and Taylor, 1999;Lyvers, 2000;Everitt and Robbins, 2005;Bekker et al, 2005). Frontal lobe dysfunction may result from alcohol-related brain damage (Oscar-Berman and Ksenija, 2007;Dirksen et al, 2006). Anderson et al (2005) showed that greater BOLD response to inhibition during a Go/No-Go task predicted more expectancies of cognitive and motor impairments from alcohol in adolescents.…”

Section: Go/no-go Behavioral Performance and Fmri Activitymentioning

confidence: 99%

Influence of Alcohol Use on Neural Response to Go/No-Go Task in College Drinkers

Ahmadi

Pearlson

Meda

et al. 2013

Neuropsychopharmacol

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Impaired inhibition of prepotent motor response may represent an important risk factor for alcoholism. Alcohol use may also increase impulsive behavior, including impaired response inhibition. Little is known about the brain function underlying response inhibition among college-age drinkers based on their drinking patterns, despite college-age drinkers demonstrating high rates of alcohol-use disorders. Our major objective was to compare behavior and associated brain activity measured with fMRI during a response-inhibition task in matched heavy-and light-alcohol-drinking college students. Participants were light (N ¼ 36) and heavy (N ¼ 56) drinkers, aged 18-20 years. We characterized blood oxygen level-dependent (BOLD) responses, while participants performed an fMRI Go/No-Go task to quantify inhibitory behavior and brain activity. Behaviorally, group performance differences were observed for Go correct-hit and No-Go falsealarm reaction times with increased reaction times in heavy compared with light drinkers. During fMRI No-Go correct rejections, light drinkers exhibited greater BOLD response than did heavy drinkers in left supplementary motor area (SMA), bilateral parietal lobule, right hippocampus, bilateral middle frontal gyrus, left superior temporal gyrus, and cingulate gyrus/anterior cingulate cortex (Brodmann area 24). Group differences in Go/No-Go-related regional activations correlated with alcohol-and impulsivity-related measures. These findings suggest that heavy alcohol drinkers may have dysfunction in brain regions underlying attention and response inhibition, leading to diminished abilities to suppress prepotent responding. The extent to which these tendencies relate to impulsive decision-making and behaviors in real-life settings and may guide intervention development warrants additional investigation.

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“…Previous studies found that alcohol drinkers experienced more difficulties as to the problem solving, flexibility of cognitive, working memory, repetitive responding, self-regulation, and demonstrated prefrontal neuro-behavioural dysfunction (19)(20)(21). Furthermore, subjects with alcoholism demonstrated deficits in explicit memory, visuospatial processes, and motor control (i.e., gait, speed and balance) (22,23).…”

Section: Discussionmentioning

confidence: 99%

Association Between Alcohol Consumption and Academic Achievement: a Cross-sectional Study

Sung

Jeong

2016

Cent Eur J Public Health

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SUMMARYAim: Alcohol consumption among adolescents is a serious public health problem in South Korea. Our study examined the relationship between alcohol consumption and academic achievement in Korean adolescents. In 2011, 75,643 students from seventh to twelfth grade participated in the Seventh Korea Youth Risk Behaviour Web-based Survey (KYRBWS-VII)Method: We performed multivariate logistic regression analysis to examine the associations between alcohol consumption, frequency of severe alcohol intoxication, and academic achievement for both girls and boys.Results: Compared to non-drinkers, the odds of achieving average or higher academic performance significantly decreased for both boys and girls with increasing number of days per month with reported alcohol consumption (p ≤ 0.008). Further, odds of achieving average or higher academic performance significantly decreased with increasing amounts of alcohol consumed compared to non-drinkers (p ≤ 0.026). Additionally, the odds of achieving average or higher academic performance according to the frequency of severe alcohol intoxication were only significantly decreased for 1-2 days per month of severe intoxication (p < 0.001).Conclusion: Both boys and girls with increased alcohol consumption and frequency of severe alcohol intoxication had below average academic achievement in Korea. To improve academic achievement, we recommend interventions that reduce alcohol consumption among adolescents.

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Patterns of prefrontal dysfunction in alcoholics with and without Korsakoff's syndrome, patients with Parkinson's disease, and patients with rupture and repair of the anterior communicating artery

Cited by 43 publications

References 44 publications

Alcohol: Effects on Neurobehavioral Functions and the Brain

Alcohol: Effects on Neurobehavioral Functions and the Brain

Influence of Alcohol Use on Neural Response to Go/No-Go Task in College Drinkers

Association Between Alcohol Consumption and Academic Achievement: a Cross-sectional Study

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