Patterns of Plasma Cortisol, Luteinizing Hormone (LH), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF 1 ) Concentrations in Clenbuterol Treated Veal Calves.

Sauerwein, H.; Rinke, L. M.; Richter, Thomas; Meyer, Heinrich

doi:10.1262/jrd.39.229

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“…It is not surprising that the beta-agonist was not found to be immunosuppressive in the present study, as cortisol was not elevated by the beta-agonist. This is consistent with previous studies that reported that betaagonists do not affect cortisol concentration in lambs and calves under conventional conditions (Beermann et al 1987;Chikhou et al 1991;Sauerwein et al 1993). Although it was reported that clenbuterol suppressed humoral immunological function in lambs (Spencer and Oliver 1996), our results indicate that L-644,969 did not affect cellmediated immune response in terms of leukocyte profile and lymphocyte function.…”

Section: Discussionsupporting

confidence: 93%

Effects of beta-adrenergic receptor agonist and low environmental temperature on the immune system of growing lambs

Li¹,

Christopherson

Field

2000

Can. J. Anim. Sci.

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2000. Effects of beta-adrenergic receptor agonist and low environmental temperature on the immune system of growing lambs. Can. J. Anim. Sci. 80: 605-613. Sixteen lambs were studied to examine the effects of cold environment and a beta-agonist on their immune status. The beta-agonist, L-646, 969, was fed for 4 wk at 0.28 or 0 mg kg-0.75 BW to animals housed in a warm (20°C) or a moderately cold (0°C) environment. The cold environment suppressed PWM-stimulated proliferation at week 3 (P < 0.03) and week 4 (P < 0.01). The percentage of CD4 cells and CD4:CD8 cell ratio were decreased at week 1 (P < 0.02; P < 0.05) and week 3 (P < 0.001; P < 0.003), and the percentage of CD2 cells (P < 0.05) was decreased at week 2 at the low-temperature. The beta-agonist did not influence leukocyte profile and lymphocyte functions. The results suggest that a cold environment may influence immune function by suppressing lymphocytes expressing CD2, CD4 and CD4:CD8 cell ratio, and changing lymphocyte proliferative response to a T cell mitogen. Further investigation is required to identify the effects of prolonged and intense cold exposure on the immune system with a large number of animals and the implications of current observations for the health of animals in a cold environment. Li, Y. Z., Christopherson, R. J. et Field, C. J. 2000. Effets d'un agoniste adrénergique de type β β et d'une basse température d'ambiance sur le système immunitaire des agneaux en croissance. Can. J. Anim. Sci. 80: 605-613. Seize agneaux faisaient l'objet de travaux sur les effets d'un environnement froid et d'un β-agoniste sur leur état immunitaire. Le β-agoniste L-646, 969 était administré pendant 4 semaines à raison de 0,28 ou de 0 mg kg-0.75 PC à des animaux logés en bergerie chaude (20°C) ou modérément froide (0°C). Le logement en milieu froid avait pour effet d'inhiber la prolifération lymphocytaire stimulée par le mitogène du Phytolacca à la semaine 3 (P < 0,03) et à la semaine 4 (P < 0,01). Le pourcentage de cellules CD4 et le rapport cel-lulaire CD4 : CD8, diminuaient à la semaine 1 (P < 0,02 et P < 0,05) et à la semaine 3 (P < 0,001 et P < 0,003). En outre, le pour-centage de cellules CD2 (P < 0,05) présentait une diminution à la semaine 2. Le β-agoniste n'avait pas d'influence sur le profil lymphocytaire ni sur les fonctions des lymphocytes. Il se dégage de ces observations qu'un milieu froid peut perturber la fonction immunitaire en inhibant les lymphocytes exprimant les types cellulaires CD2 et CD4 ainsi que le ratio CD4 :CD8 et en modifiant la réponse proliférative des lymphocytes à un mitogène des cellules T. Il reste à poursuivre la recherche pour dégager, d'une part, les effets sur grand nombre d'animaux d'une exposition prolongée et intense au froid sur le système immunitaire et, d'autre part, la signification des observations courantes pour la santé des animaux en milieu froid. that heat stress suppressed immunity in chickens by increasing the ratio of neutrophil to lymphocytes and in rabbits by decreasing the capacity of peripheral bloo...

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Section: Discussionsupporting

confidence: 93%

Effects of beta-adrenergic receptor agonist and low environmental temperature on the immune system of growing lambs

Li¹,

Christopherson

Field

2000

Can. J. Anim. Sci.

View full text Add to dashboard Cite

show abstract

Patterns of Plasma Cortisol, Luteinizing Hormone (LH), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF 1 ) Concentrations in Clenbuterol Treated Veal Calves.

Abstract: The possible influence of a ƒÀ-adrenergic agonist, Clenbuterol, on GH, IGF-1, LH and cortisol secretion was investigated in young female calves. Clenbuterol (5 ƒÊg/kg liveweight) was fed

Cited by 1 publication

References 28 publications

Effects of beta-adrenergic receptor agonist and low environmental temperature on the immune system of growing lambs

Effects of beta-adrenergic receptor agonist and low environmental temperature on the immune system of growing lambs

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