Patterns of persistent genital human papillomavirus infection among women worldwide: A literature review and meta-analysis

Rositch, Anne F.; Koshiol, Jill; Hudgens, Michael G.; Razzaghi, Hilda; Backes, Danielle M.; Pimenta, Jeanne M.; Franco, Eduardo L.; Poole, Charles; Smith, Jennifer S.

doi:10.1002/ijc.27828

Cited by 188 publications

(178 citation statements)

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“…The propensity for certain genotypes to persist longer than others (Rositch et al, 2013) may contribute to the observed HPV genotype distribution differences between low-grade disease and cervical cancer (Guan et al, 2012).…”

Section: Received 5 November 2014 Accepted 12 March 2015mentioning

confidence: 99%

“…Although the proportions of individuals were similar between the HPV16 and HPV51 NI status categories, neutralizing antibody titres against HPV16 tended be higher than those against HPV51. This may indicate true differences in the host response to infection between these genotypes and differences in persistence (Rositch et al, 2013) and/or highlight subtle differences in the ability of HPV pseudoviruses to mimic their archetypal strain.These data improve our understanding of a little-studied oncogenic HPV genotype, HPV51, and demonstrate the importance of selecting representative HPV sequences, including consideration of variation in both the major and minor capsid proteins, for the construction of appropriate antigens. These data also corroborate recent observations of poor concordance between the VLP ELISA and the pseudovirus neutralization assay for measuring NI antibodies (Safaeian et al, 2012) in contrast to the generally good concordance for measuring vaccine-induced typespecific antibody (Dessy et al, 2008;Krajden et al, 2014).…”

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confidence: 99%

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Amino acid motifs in both the major and minor capsid proteins of HPV51 impact antigenicity and infectivity

Godi

Epifano

Bissett

et al. 2015

Journal of General Virology

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Persistent infection with oncogenic human papillomavirus (HPV) is a prerequisite for cervical disease development, yet data regarding the host immune response to infection at the genotype level are quite limited. We created pseudoviruses bearing the major (L1) and minor (L2) capsid proteins and L1 virus-like particles representing the reference sequence and a consensus of 34 European sequences of HPV51. Despite the formation of similarly sized particles, motifs in the reference L1 and L2 genes had a profound impact on the immunogenicity, antigenicity and infectivity of these antigens. The antibody status of women exhibiting low-grade disease was similar between HPV16 and the consensus HPV51, but both demonstrated discrepancies between binding and neutralizing antibody responses. These data support the use of pseudoviruses as the preferred target antigen in studies of natural HPV infection and the need to consider variation in both the L1 and L2 proteins for the appropriate presentation of antibody epitopes. Received 5 November 2014 Accepted 12 March 2015Persistent infection with one or more of about a dozen human papillomavirus (HPV) genotypes (Bouvard et al., 2009) is associated with the development of cervical cancer, a significant cause of morbidity and mortality in women worldwide (Schiffman et al., 2007). The propensity for certain genotypes to persist longer than others (Rositch et al., 2013) may contribute to the observed HPV genotype distribution differences between low-grade disease and cervical cancer (Guan et al., 2012).The non-enveloped capsid of HPV comprises the major (L1) and minor (L2) capsid proteins. The L1 protein facilitates virus attachment to host cells, whilst the L2 protein is essential for subsequent virus infectivity (Buck et al., 2013;Raff et al., 2013;Wang & Roden, 2013).Current L1 virus-like particle (VLP)-based HPV vaccines target the most prevalent genotypes, HPV16 and HPV18, and elicit type-specific neutralizing antibodies thought to confer the high levels of efficacy observed in clinical trials (Lehtinen & Dillner, 2013;Schiller et al., 2012). A limited number of serological assays are available for measuring vaccine type-specific antibody responses, including an L1 VLP ELISA, a mAb competitive VLP assay and an L1L2 pseudovirus neutralization assay. Despite some discrepancies, overall inter-assay agreements are good (Dessy et al., 2008;Krajden et al., 2014). Natural infection (NI) studies usually compare the HPV DNA status of individuals with their respective antibody status in order to better understand the pathogen-host relationship. Most of these studies have examined HPV16 and/or HPV18 (Castellsagué et al., 2014;Lin et al., 2013;Pastrana et al., 2004; Safaeian et al., 2010;Xi et al., 2002), whilst some have expanded their investigations to evaluate other genotypes including HPV6, HPV11, HPV31, HPV33, HPV35, HPV45, HPV52 and HPV58 (Carter et al., 2000;Ochi et al., 2008; Syrjänen et al., 2009;Wilson et al., 2013). Most of these studies have made use of an immobilized L1-based t...

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Section: Received 5 November 2014 Accepted 12 March 2015mentioning

confidence: 99%

mentioning

confidence: 99%

Amino acid motifs in both the major and minor capsid proteins of HPV51 impact antigenicity and infectivity

Godi

Epifano

Bissett

et al. 2015

Journal of General Virology

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“…According to multiple studies, the status of HPV infection may be incident (which is negative at start of study "baseline" and become positive after that), persistent (detecting the same HPV type at 2 or more examinations 6 month apart), multiple, or high risk infection (12,13) .…”

Section: Materials and Methods:-mentioning

confidence: 99%

Abnormal Pap Tests in Systemic Lupus Erythematosis: A Cytopathological and Human Papillomavirus Testing Study.

Girbash¹,

Atta²,

Fahmy³

et al. 2016

IJAR

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Objectives: the frequency of cervical squamous intra-epithelial lesions (SIL) in women with systemic lupus erythematosus (SLE), and the association between clinical parameters, use of immunosuppressant agents, human papillomavirus (HPV) infection, colposcopy, and development of SIL in SLE.Methods: A retrospective case control study conducted in 150 women constituted the study group with confirmed diagnosis of SLE. The enrolled patients divided into study group (no.28) with abnormal pap smears and reference group (no.122) with normal pap smears. All patients subjected to clinical evaluation, colposcopy, directed biopsies, and HPV-ISH testing. All participants reassessed every 6 months for 2 years.Results: mean patient age with abnormal pap smears was 44.8(P = 0.74) years with mean SLE disease duration was 9.3±7.1 years. There was past history of cervical lesions where it was positive in 89.3% (P = 0.001). SLE patients with abnormal pap smears showed significant difference regarding nephritis (P = 0.001) and high titers of Anti-double stranded DNA (P = 0.001) and Antiphospholipid antibodies (P = 0.012). SLEDAI, SDI, and immunosuppressant agent usage found significantly different among patients with abnormal pap smears. HPV Infection found significantly important (P = 0.001) when the infection was high-risk HPV, multiple HPV, or persistent HPV infection among patients with abnormal pap smears. On comparison with cytology, colposcopy, HPV-ISH results, the best sensitivity was with the use of HPV-ISH (90%) then with colposcopy (75%). In addition, the best specificity was with the use of colposcopy (99%). The highest positive predictive value was with colposcopy (94%) and the highest negative predictive value was with HPV-ISH assay (98%). Conclusion:Patients with SLE had higher risk for HPV infection and cervical dysplasia than the general population. Thus, gynecological visits at shorter intervals (3-6 months) recommended for those patients. The use of colposcopy is useful tool in areas where the screening of HPV is not available.

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“…Some disease processes are dependent on both the current state of the system and its history [14]. The classic SIR model cannot accomodate this; however, the age-structured models of Kermack and McKendrick [2,3] can model such diseases.…”

Section: Introductionmentioning

confidence: 99%

A Fractional-Order Infectivity and Recovery SIR Model

2017

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Abstract:The introduction of fractional-order derivatives to epidemiological compartment models, such as SIR models, has attracted much attention. When this introduction is done in an ad hoc manner, it is difficult to reconcile parameters in the resulting fractional-order equations with the dynamics of individuals. This issue is circumvented by deriving fractional-order models from an underlying stochastic process. Here, we derive a fractional-order infectivity and recovery Susceptible Infectious Recovered (SIR) model from the stochastic process of a continuous-time random walk (CTRW) that incorporates a time-since-infection dependence on both the infectivity and the recovery of the population. By considering a power-law dependence in the infectivity and recovery, fractional-order derivatives appear in the generalised master equations that govern the evolution of the SIR populations. Under the appropriate limits, this fractional-order infectivity and recovery model reduces to both the standard SIR model and the fractional recovery SIR model.

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Patterns of persistent genital human papillomavirus infection among women worldwide: A literature review and meta-analysis

Cited by 188 publications

References 109 publications

Amino acid motifs in both the major and minor capsid proteins of HPV51 impact antigenicity and infectivity

Amino acid motifs in both the major and minor capsid proteins of HPV51 impact antigenicity and infectivity

Abnormal Pap Tests in Systemic Lupus Erythematosis: A Cytopathological and Human Papillomavirus Testing Study.

A Fractional-Order Infectivity and Recovery SIR Model

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