Patterns of multispecialty care for low- and intermediate-risk prostate cancer in the use of active surveillance

Zambrano, Ibardo; Hwang, Soohyun; Basak, Ramsankar; Spratte, Brooke Namboodri; Filson, Christopher P.; Jacobs, Bruce L.; Tan, Hung‐Jui

doi:10.1016/j.urolonc.2023.04.024

Cited by 1 publication

(2 citation statements)

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“…20 Drug treatment for prostate cancer, including endocrine therapy and chemotherapy drugs, has limited effect on patients with advanced tumors. 18 Here, we noticed that a new drug, CHD, could suppress prostate cancer progression in vitro as well as in mice. We therefore thought it could serve as a drug for prostate cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

“…2 Therefore, there is huge room for future therapeutic innovation, and customized genetic analysis is likely to play a role in reducing prostate cancer prevalence. 18 Dysregulation of apoptosis is important in the pathogenesis of prostate cancer and is thought to be a key driver of the exponential growth of tumor cells. 19 Expanding our understanding of the pathogenesis of prostate cancer is critical.…”

Section: Discussionmentioning

confidence: 99%

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Chrysosplenol D can inhibit the growth of prostate cancer by inducing reactive oxygen species and autophagy

Zhang,

You,

et al. 2023

Immunity Inflam & Disease

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ObjectiveTo uncover the effects of chrysosplenol D (CHD) on the progression of prostate cancer in vitro as well as in mice.MethodsDU145 and PC‐3 cells were treated with increasing doses of CHD for 24, 48, or 72 h. Cell Counting Kit‐8 (CCK‐8) and colony formation assays were conducted to confirm the effects of CHD on cell viability. Flow cytometry (FCM) and immunostaining assays showed the effects of CHD on cell apoptosis and oxidative stress. Immunoblot was performed to detect the effects of CHD on autophagy. Besides, tumor growth assays were conducted to confirm the role of CHD in tumor growth in mice. GraphPad 6.0 was used for statistical analysis. All data were represented as mean ± SD. p < .05 and the significant difference was indicated by an asterisk.ResultsCHD suppressed the viability of prostate cancer cells in CCK‐8 assays, decreased colony number in colony formation assays, and induced cell apoptosis in FCM and immunostaining assays. CHD also restrained the oxidative stress with a decreased 2′‐7′‐dichlorofluorescein diacetate staining intensity. CHD restrained the autophagy of prostate cancer cells, as well as suppressed tumor growth in mice.ConclusionCHD could serve as a drug for prostate cancer.

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Section: Discussionmentioning

confidence: 99%