Patterns of Migration of Labelled Blood Lymphocyte Subpopulations: Evidence for Two Types of Peyer’s Patch in the Young Pig

Binns, R. M.; Licence, S. T.

doi:10.1007/978-1-4613-2463-8_81

Cited by 39 publications

(50 citation statements)

References 6 publications

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“…A better label is fluorescein-isothiocyanate (FITC). The advantage of this label has carefully been demonstrated, and it is possible to study the distribution of cells in their histological situation [8,10,100]. Other fluorescence markers have been developed which enable a longer lasting staining profile e.g.…”

Section: Lymphocyte Compartments and Methods For Lymphocyte Migrationmentioning

confidence: 99%

Lymphocyte migration studies

Bimczok

Rothkötter

2006

Vet. Res.

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-For maintenance of immunity and tolerance, the organs and tissues of the organism are connected by migrating lymphoid cells. Understanding lymphocyte migration is essential for many disorders and diseases -especially in the mucosa-lined organs. Detailed analyses of migrating lymphocytes have been performed in many species, especially in laboratory animals. However, important experiments in lymphocyte migration have been carried out in large animals, for example sheep, cattle and pigs. These species allow experimental procedures like in situ-organ labelling, lymphocyte retransfusion studies or lymph vessel cannulations. Such studies have made an important contribution to the understanding of the overall principles of lymphocyte migration especially in the mucosal immune system. Major results on the specific migration of naïve and memory T cells through lymphoid organs, the re-distribution of γ/δ T cells in the intestinal immune system and the emigration of newly produced B cells from the ileal Peyer's patches have been obtained in large animals. Since there are growing numbers of markers for large animals, and molecular biology methods are available in these species, experiments in large animals will be an essential tool for the understanding of lymphocyte migration especially in mucosal organs.

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Section: Lymphocyte Compartments and Methods For Lymphocyte Migrationmentioning

confidence: 99%

Lymphocyte migration studies

Bimczok

Rothkötter

2006

Vet. Res.

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“…On the contrary, the ileal PP (IPP) occurs as a continuous patch, commencing near the ileo-caecal junction and extending for up to 2 m along the terminal ileum but shrinks within a year to form discrete patches. In contrast to the JPP, the porcine IPP has characteristics of a primary lymphoid organ (in comparison with the JPP, low lymphocyte migration, smaller interfollicular regions, higher incidence of B cells [6,10] and identification of the majority (> 90) of follicular cells as apoptosis-sensitive immature B cells [3]). However, the use of gut-associated lymphoid tissues as a site of repertoire diversification in swine has been a subject of debate in the literature.…”

Section: Structure Of Igamentioning

confidence: 98%

“…This group, unlike rodents and humans, has a single V H family and uses lymphoid follicles associated with the lower gut early in life (rather than bone marrow throughout life) to diversify their antibody repertoire via gene conversion as well as somatic hypermutation [20,21,55,94,95]. Indeed, in the pig, different Peyer's patches (PP) are present [10]. The jejunal PP (JPP) are distributed as discrete patches along the jejunum and proximal ileum and persist throughout life.…”

Section: Structure Of Igamentioning

confidence: 99%

The IgA system: a comparison of structure and function in different species

2006

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-The predominant immunoglobulin isotype on most mucosal surfaces is secretory immunoglobulin A (SIgA), a polypeptide complex comprising two IgA monomers, the connecting J chain, and the secretory component. The molecular stability and strong anti-inflammatory properties make SIgA particularly well suited to provide protective immunity to the vulnerable mucosal surfaces by preventing invasion of inhaled and ingested pathogens. In contrast to SIgA, IgA in serum functions as an inflammatory antibody through interaction with FcαR on immune effector cells. Although IgA appears to share common features and protective functions in different species, significant variations exist within the IgA systems of different species. This review will give an overview of the basic concepts underlying mucosal IgA defence which will focus on the variations present among species in structure, antibody repertoire development, pIgR-mediated transport, colostral IgA content, hepatobiliary transport, and function with particular emphasis on the IgA system of the pig and dog. These interspecies variations emphasise the importance of elucidating and analysing the IgA system within the immune system of the species of interest rather than inferring roles from conclusions made in human and mouse studies.

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“…Peyer's patches have been described in the domestic pig and are known to reside in the small (jejunum and ileum) and large (spiral colon) intestine (Chu and Liu, 1984;Binns and Licence, 1985;Lowden and Heath, 1994). Within the small intestine of pigs, discrete Peyer's patches are found in the jejunum and upper ileum, and a continuous Peyer's patch is evident along the terminal ileum (Rothkotter et al, 1990).…”

Section: Galt Inductive Sitesmentioning

confidence: 99%

BOARD-INVITED REVIEW: Porcine mucosal immunity of the gastrointestinal tract1

Burkey

Skjolaas²,

Minton

2009

Journal of Animal Science

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ABSTRACT:The gastrointestinal tract (GIT) constitutes one of the largest immunological organs of the body. The GIT must permit absorption of nutrients while also maintaining the ability to respond appropriately to a diverse milieu of dietary and microbial antigenic components. Because of the diverse population of antigenic components within the GIT, a sophisticated mucosal immune system has evolved that relies on collaboration between the innate and adaptive arms of immunity. The collaborative, mucosal immune effort offers protection from harmful pathogens while also being tolerant of dietary antigens and normal microbial flora. Knowledge with respect to porcine mucosal immunity is important as we strive to understand the interrelationships among GIT physiology, immunology, and the resident microbiota. The aim of this review is to provide a descriptive overview of GIT immunity and components of the mucosal immune system and to highlight differences that exist between the porcine species and other mammals.

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Patterns of Migration of Labelled Blood Lymphocyte Subpopulations: Evidence for Two Types of Peyer’s Patch in the Young Pig

Cited by 39 publications

References 6 publications

Lymphocyte migration studies

Lymphocyte migration studies

The IgA system: a comparison of structure and function in different species

BOARD-INVITED REVIEW: Porcine mucosal immunity of the gastrointestinal tract1

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