Patterns of malformation associated with esophageal atresia/tracheoesophageal fistula: A retrospective single center study

Galarreta, Carolina I.; Vaida, Florin; Bird, Lynne M.

doi:10.1002/ajmg.a.61582

Cited by 19 publications

(22 citation statements)

References 60 publications

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“…The incidence of anomalies associated with EA ± TEF ranges between 30% and 60% in different studies. [ 5 10 11 ] In ours, 50% had VACTERL association similar to Galarreta et al study. [ 11 ] Half of the cases with DA were associated with Down syndrome as reported in previous studies.…”

Section: Discussionsupporting

confidence: 89%

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Clinical profile, outcomes and predictors of mortality in neonates operated for gastrointestinal anomalies in a tertiary neonatal care unit- An observational study

Jerry

Amboiram

Balakrishnan

et al. 2022

J Indian Assoc Pediatr Surg

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Section: Discussionsupporting

confidence: 89%

“…[ 5 10 11 ] In ours, 50% had VACTERL association similar to Galarreta et al study. [ 11 ] Half of the cases with DA were associated with Down syndrome as reported in previous studies. [ 6 ] Genetic predisposition along with environmental factors have been implicated in the pathogenesis of IHPS.…”

Section: Discussionsupporting

confidence: 89%

Clinical profile, outcomes and predictors of mortality in neonates operated for gastrointestinal anomalies in a tertiary neonatal care unit- An observational study

Jerry

Amboiram

Balakrishnan

et al. 2022

J Indian Assoc Pediatr Surg

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“…Most of the study do not represent any gender differences, but in our study the number of male patients were more compared to the female counterpart. Such findings have also been identified in some studies [15,17,[22][23][24] . This could be attributed to preference to male child in our country and increasing feticide leading to hospital admission bias.…”

Section: Discussionsupporting

confidence: 83%

A retrospective comparative study to determine the factors leading to poor outcome in operated cases of esophageal atresia and trachea-esophageal fistula: An audit

B¹,

Nayak²,

M³

2021

Int. J. Surg. Sci.

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To determine the different factors leading to poor outcome in operated case of esophageal atresia and trachea-esophageal fistula (EA-TEF). Material and Methods: This is a retrospective non-randomized comparative study. All the patient who presented with EA-TEF to us were included in the study. The patients who were not operated and patient who were discharged against the advice were excluded from the study. Patients were divided in to two groups. Group-A-Those who have survived after the surgery-39 and Group-B those who expired after the surgery-38. Various parameters were considered in relation to pre-operative, intra-operative and postoperative factors. To name few antenatal findings, maternal hemoglobin, gestational age, gap between both the end, duration of procedure, need for mechanical ventilation, early start of NG feed, need for blood products and postoperative complications. Results: Preoperative factor which had significant negative impact on survival were antenatally diagnosed polyhydramnios, maternal anemia, gestational age and associated severe cardiac anomalies. Mean operating time was more in group-B. Whenever surgeons or anaesthesiologists decided to continue postoperative ventilation the outcome was poor-34 needed post-operative ventilation in group-B versus 12 in group A. Need for blood transfusion and need for platelets transfusion did not show significant difference among two groups but the need for plasma transfusion had poor survival. SIRS/sepsis played important determining factor in survival of EA-TEF. Patients who could be fed early, had better survival. Pneumothorax, pneumonia and leak didn't show significant difference in survival. Conclusion: Different factors before, during and after the surgery have impact on outcome of EA-TEF. We should be able to formulate prognostic score which is based our local needs and available resources.

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“…At present, it is difficult to make prenatal diagnosis of EA. It was reported that only about 1/3 of EA cases were diagnosed before delivery [ 12 ]. In recent years, magnetic resonance imaging (MRI) has been used in the prenatal diagnosis of EA.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Prenatal Ultrasound Parameters and Esophageal Signs in Pouch and Lower Thoracic Segment in Fetuses with Esophageal Atresia

Feng

2021

Computational and Mathematical Methods in Medicine

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In order to investigate the diagnostic value of prenatal ultrasound parameters and signs of pouch and lower thoracic esophagus in the fetus with esophageal atresia (EA), the prenatal ultrasound data of 35 EA fetuses (observation group) confirmed by autopsy after induced labor or postnatal surgery and imaging examination in our hospital from May 2019 to May 2021 were retrospectively analyzed and compared with 35 normal postnatal fetuses (control group). General information and prenatal ultrasound parameters of the two groups, including head circumference (HC), abdominal circumference (AC), double parietal diameter (BPD), fetal body weight (EFW), and signs (small or unmanifested gastric vesicles, amniotic fluid, neck or upper chest pouch, lower chest esophagus not visible), were analyzed using logistic regression. The logistic multifactor regression model for EA diagnosis was established, and the diagnostic value for EA was analyzed. As a result, the HC, AC, and EFW of the observation group were lower than those of the control group, the gastric bubbles were small or not displayed, the amniotic fluid was more, and the signs of neck or upper chest pouch and lower chest esophagus were not visible in the observation group ( P < 0.05 ). Logistic regression analysis showed that decreased ultrasound parameters HC, AC, EFW, small or no gastric bubble, amniotic fluid, neck or upper chest pouch, and no visible signs of lower chest esophagus were all risk factors for EA ( P < 0.05 ). And in the prenatal ultrasound diagnostic model of EA was established, logistic P = − 19.851 + HC × 0.384 + AC × 0.682 + EFW × 0.695 + small or no gastric vesicle × 3.747 + amniotic fluid × 3.607 + cervical or upper chest sac × 4.104 + invisible lower thoracic esophagus × 4.623 .When logistic P > 0.468 , AUC was 0.891, χ 2 was 7.764, diagnostic sensitivity was 91.24%, and specificity was 79.22%. To draw a conclusion, prenatal ultrasound parameters and signs are of great value in the diagnosis of EA. Independent influencing factors of EA include small or no HC, AC, EFW and gastric vesicles, polyhydramnios, neck or upper chest pouch, and invisible lower thoracic esophagus. Logistic multifactor regression model has a high coincidence rate for the prenatal diagnosis of EA, providing a basis for clinical decision-making.

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Patterns of malformation associated with esophageal atresia/tracheoesophageal fistula: A retrospective single center study

Abstract: Esophageal atresia/tracheoesophageal fistula (

Cited by 19 publications

References 60 publications

Clinical profile, outcomes and predictors of mortality in neonates operated for gastrointestinal anomalies in a tertiary neonatal care unit- An observational study

Clinical profile, outcomes and predictors of mortality in neonates operated for gastrointestinal anomalies in a tertiary neonatal care unit- An observational study

A retrospective comparative study to determine the factors leading to poor outcome in operated cases of esophageal atresia and trachea-esophageal fistula: An audit

Diagnostic Value of Prenatal Ultrasound Parameters and Esophageal Signs in Pouch and Lower Thoracic Segment in Fetuses with Esophageal Atresia

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