Patterns of language decline in non-fluent primary progressive aphasia

Thompson, Cynthia K.; Ballard, Kirrie J.; Tait, Mary; Weıntraub, Sandra; Mesulam, Marek-Marsel

doi:10.1080/02687039708248473

Cited by 132 publications

(122 citation statements)

References 16 publications

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“…It is characterized by effortful and agrammatic speech which is often dysarthric and contains phonemic paraphasic errors (Grossman, 2002). PNFA patients often have difficulty understanding grammatical aspects of sentences (Grossman & Ash, 2004;Grossman et al, 1996;Snowden, Neary, Mann, Goulding, & Testa, 1992;Thompson, Ballard, Tait, Weintraub, & Mesulam, 1997).…”

Section: Introductionmentioning

confidence: 99%

Syntactic and thematic components of sentence processing in progressive nonfluent aphasia and nonaphasic frontotemporal dementia

Peelle¹,

Cooke²,

Moore³

et al. 2007

Journal of Neurolinguistics

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We used an online word-monitoring paradigm to examine sentence processing in healthy seniors and frontotemporal dementia patients with progressive nonfluent aphasia (PNFA) or a nonaphasic disorder of social and executive functioning (SOC/EXEC). Healthy seniors were sensitive to morphosyntactic, major grammatical subcategory, and selection restriction violations in a sentence. PNFA patients were insensitive to grammatical errors, but showed reasonable sensitivity to thematic matrix violations, consistent with a differential grammatical processing impairment. By contrast, SOC/EXEC patients showed partial sensitivity to grammatical errors but were insensitive to thematic violations. These findings support a dissociation between grammatical and thematic components of sentence processing. Specifically, they are consistent with a grammatical processing deficit in PNFA patients, and impairment in the formation of a coherent thematic matrix in SOC/EXEC patients.

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Section: Introductionmentioning

confidence: 99%

Syntactic and thematic components of sentence processing in progressive nonfluent aphasia and nonaphasic frontotemporal dementia

Peelle¹,

Cooke²,

Moore³

et al. 2007

Journal of Neurolinguistics

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“…A few studies also have examined narrative production in individuals with PPA, with several noting syntactic and morphosyntactic impairments in nonfluent PPA as compared to normal or fluent PPA speakers [3,47,55,57,68]. Thompson et al [55] presented the results of an in depth longitudinal analysis of four patients, then diagnosed with nonfluent PPA, and found low proportions of grammatical sentences and correct verb morphology, high ratios of open-to closed-class words, and high noun to verb ratios in the patients compared to healthy control speakers.…”

Section: And Others)mentioning

confidence: 99%

“…According to current guidelines, PPA can be subdivided into three variants: agrammatic/ nonfluent (PPA-G), logopenic (PPA-L), and semantic (PPA-S) [27,29,42]. Individuals with the PPA-G variant present with nonfluent speech, verb production deficits, and difficulties with comprehension and production of syntactically complex sentences [13,32,34,48,55,64,67]. Conversely, PPA-L is associated with fluctuating fluency, difficulties with word retrieval, and impaired repetition, with relatively spared syntax and word comprehension [28], and individuals with PPA-S show relatively fluent patterns of speech production, but have problems with naming and comprehension of single words [35,41,42].…”

Section: Introductionmentioning

confidence: 99%

Syntactic and Morphosyntactic Processing in Stroke-Induced and Primary Progressive Aphasia

Thompson

Meltzer‐Asscher

Cho

et al. 2013

Behavioural Neurology

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Abstract. The paper reports findings derived from three experiments examining syntactic and morphosyntactic processing in individuals with agrammatic and logopenic variants of primary progressive aphasia (PPA-G and PPA-L, respectively) and strokeinduced agrammatic and anomic aphasia (StrAg and StrAn, respectively). We examined comprehension and production of canonical and noncanonical sentence structures and production of tensed and nontensed verb forms using constrained tasks in experiments 1 and 2, using the Northwestern Assessment of Verbs and Sentences (NAVS [57]) and the Northwestern Assessment of Verb Inflection (NAVI, Thompson and Lee, experimental version) test batteries, respectively. Experiment 3 examined free narrative samples, focusing on syntactic and morphosyntactic measures, i.e. production of grammatical sentences, noun to verb ratio, open-class to closed-class word production ratio, and the production of correctly inflected verbs. Results indicate that the two agrammatic groups (i.e., PPA-G and StrAg) pattern alike on syntactic and morphosyntactic measures, showing more impaired noncanonical compared to canonical sentence comprehension and production and greater difficulties producing tensed compared to nontensed verb forms. Their spontaneous speech also contained significantly fewer grammatical sentences and correctly inflected verbs, and they produced a greater proportion of nouns compared to verbs, than healthy speakers. In contrast, PPA-L and StrAn individuals did not display these deficits, and performed significantly better than the agrammatic groups on these measures. The findings suggest that agrammatism, whether induced by degenerative disease or stroke, is associated with characteristic deficits in syntactic and morphosyntactic processing. We therefore recommend that linguistically sophisticated tests and narrative analysis procedures be used to systematically evaluate the linguistic ability of individuals with PPA, contributing to our understanding of the language impairments of different PPA variants.

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“…5 Fluency (i.e., words per minute [WPM]) was quantified from a recorded story narrative. 7,8 Sentence production scores on 2 subsets of 15 noncanonical sentences, one from the Northwestern Anagram Test (NAT; flintbox.com/public/project/19927) 9 and another from the Sentence Production Priming Test of the Northwestern Assessment of Verbs and Sentences (NAVS-SPPT), 10 were averaged to derive a composite score of grammaticality of sentence production. 5 The NAT does not require oral responses and was specifically designed to dissociate agrammatism from lack of fluency.…”

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confidence: 99%

Aphasic variant of Alzheimer disease

et al. 2016

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Objective: To identify features of primary progressive aphasia (PPA) associated with Alzheimer disease (AD) neuropathology. A related objective was to determine whether logopenic PPA is a clinical marker for AD.Methods: A total of 139 prospectively enrolled participants with a root diagnosis of PPA constituted the reference set. Those with autopsy or biomarker evidence of AD, and who had been evaluated at mild disease stages (Aphasia Quotient $85), were included (n 5 19). All had quantitative language testing and APOE genotyping. Fifteen had MRI morphometry.Results: Impaired word-finding was the universal presenting complaint in the aphasic AD group.PPA clinical subtype was logopenic (n 5 13) and agrammatic (n 5 6). Fluency, repetition, naming, and grammaticality ranged from preserved to severely impaired. All had relative preservation of word comprehension. Eight of the 15 aphasic participants with AD showed no appreciable cortical atrophy at the individual level on MRI. As a group, atrophy was asymmetrically concentrated in the left perisylvian cortex. APOE e4 frequency was not elevated.Conclusions: There is a close, but not obligatory, association between logopenic PPA and AD. No language measure, with the possible exception of word comprehension, can confirm or exclude AD in PPA. Biomarkers are therefore essential for diagnosis. Asymmetry of cortical atrophy and normal APOE e4 prevalence constitute deviations from typical AD. These and additional neuropathologic features suggest that AD has biological subtypes, one of which causes PPA. Better appreciation of this fact should promote the inclusion of individuals with PPA and positive AD biomarkers into relevant clinical trials. Neurology ® 2016;87:1337-1343 GLOSSARY AD 5 Alzheimer disease; AQ 5 aphasia quotient; FDR 5 false discovery rate; FTLD 5 frontotemporal lobar degeneration; NAT 5 Northwestern Anagram Test; NAVS-SPPT 5 Sentence Production Priming Test of the Northwestern Assessment of Verbs and Sentences; NFT 5 neurofibrillary tangles; PPA 5 primary progressive aphasia; PPA-G 5 primary progressive aphasia agrammatic subtype; PPA-L 5 primary progressive aphasia logopenic subtype; PPA-S 5 primary progressive aphasia semantic subtype; SOB 5 sum of boxes; WAB-R 5 Western Aphasia Battery-Revised; WPM 5 words per minute.Primary progressive aphasia (PPA) is diagnosed when language impairment arises in relative isolation and progresses to become the primary obstacle to daily functioning. Frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD) are its most common neuropathologic correlates. The primary pathology is frequently FTLD-tau in agrammatic subtypes (PPA-G), FTLD-TDP in semantic subtypes (PPA-S), and AD in logopenic subtypes (PPA-L). 1The goal of this report is to characterize the features of PPA associated with AD. Previous investigations were based on samples of convenience with aphasias of variable severity and language testing of limited coverage, especially in the domain of grammar. The current report is based on 19 individuals w...

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Patterns of language decline in non-fluent primary progressive aphasia

Cited by 132 publications

References 16 publications

Syntactic and thematic components of sentence processing in progressive nonfluent aphasia and nonaphasic frontotemporal dementia

Syntactic and thematic components of sentence processing in progressive nonfluent aphasia and nonaphasic frontotemporal dementia

Syntactic and Morphosyntactic Processing in Stroke-Induced and Primary Progressive Aphasia

Aphasic variant of Alzheimer disease

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