Patterns of Keratin Subsets in Normal and Abnormal Uterine Cervical Tissues An Immunohistochemical Study

Malecha, Mark J.; Miettinen, Markku

doi:10.1097/00004347-199201000-00005

Cited by 6 publications

(4 citation statements)

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“…CK 13-deficient areas were quite extensive in some instances, prabably reflecting the loss of a suprabasal epithelial phe notype and the acquisition of the basal cell phenotype. This is in agreement with the findings of Malecha and Miettinen [26,27]. The sensitivity of CK 13 in detecting invasive malignancy and intraepithelial neoplasia may be useful for the differential diagnosis of difficult 'border line' cases.…”

Section: Cytokeratins In Cervical Lesionssupporting

confidence: 91%

Increased Expression of Cytokeratins 14, 18 and 19 Correlates with Tumor Progression in the Uterine Cervix

Nair

Nair²,

Jayaprakash³

et al. 1997

Pathobiology

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The expression of cytokeratins (CKs) in normal cervical ephitelium, low grade squamous intraepithelial lesions (SIL), high grade SILs and squamous cell carcinoma (SCC) were analyzed using four different monoclonal antikeratin antibodies. In normal cervical epithelium, CK 18 showed strong immunoreactivity in basal and parabasal layers. CK 19 and 14 were expressed only in the basal layer while CK 13 was found selectively in the spinal cells. As the lesions progressed from low grade SIL to high grade SIL, immunoreactivity of CK 18, 19 and 14 in the basal cell compartment increased while the expression of CK 13 decreased. In SCC, well-differentiated tumors showed decreased immunoreactivity for CK 18, 19 and 14 with CK 13 showing a strong and focal (localized) immunoreactivity. Undifferentiated carcinomas totally lacked CK 13 reactivity. Our findings therefore suggest that expression of CK 18, 19 and 14 may be directly related to tumor grade and CK 13 may be a marker of differentiation in cervical lesions.

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Section: Cytokeratins In Cervical Lesionssupporting

confidence: 91%

Increased Expression of Cytokeratins 14, 18 and 19 Correlates with Tumor Progression in the Uterine Cervix

Nair

Nair²,

Jayaprakash³

et al. 1997

Pathobiology

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“…Vang et al (21) documented that 1 of 11 OvCCC cases was negative for 34bE12 (a positive case defined as having at least 5% positively labeled cells). As well as CD 10, it is also interesting that expression of 34bE12, which was commonly detected in stratified squamous epithelium (22), were recognized in OvCCC as well as in endometrial columnar epithelium of ovarian endometriosis. …”

Section: Immunoprofile Of Clear Cell Carcinomamentioning

confidence: 96%

Expression of CD10 and Cytokeratins in Ovarian and Renal Clear Cell Carcinoma

Ohta

Suzuki

Shiokawa

et al. 2005

International Journal of Gynecological Pathology

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A solid pattern of tumor cells with a clear cytoplasm is common to both ovarian clear cell carcinoma (OvCCC) and renal clear cell carcinoma (RCCC). This study examined the possible differential expression of CD10 and cytokeratins (CK7, CK20, 34betaE12, and CAM5.2) between these two types. An immunohistochemical technique using peroxidase-labeled amino acid polymers was used to test formalin-fixed and paraffin-embedded tissues. In OvCCC, 6 of 29 cases were positive for CD10, and all cases had expression of CK7, 34betaE12, and CAM5.2. In contrast, all 24 RCCC cases had CD10 and CAM5.2 immunoreactivity, but none had any staining for 34betaE12. CK7 was only expressed in nine cases. No CK20 positivity was observed in any sample from either tumor type. Localization of CD10 expression was different in OvCCC versus RCCC. Although positive staining for 34betaE12 strongly suggests OvCCC, sometimes only a few cells may be stained. Therefore, 34betaE12-negative biopsies also should be evaluated for CD10 and CK7 immunoreactivity to enable histologic and cytologic differential diagnosis.

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“…Thus, keratins have proved to be efficient tools for characterizing the differentiation of a particular cell type and for establishing the origin of certain cells. The keratin expression patterns in the normal cervix are known to a large extent, using specific monoclonal antibodies against the individual keratin polypeptides [5,6,8,9,16]. The distribution of the keratins in the normal cervix can be summarized as follows: ectocervical nonkeratinizing squamous epithelium shows a keratin pattern characterized by intense expression of keratins 4 and 13.…”

mentioning

confidence: 99%

“…There have been a few studies with respect to the keratin expression in cervical intraepithelial neoplasia (CIN) and cervical cancer, using specific keratin antibodies [4,7,9,15]. These studies suggest that the keratin expression pattern of these lesions may supply valuable information on whether a CIN lesion is progressive or regressive in nature and CIN lesions expressing keratins 8, 18 and 19 are progressive into carcinoma.…”

mentioning

confidence: 99%

Keratin Expression in Normal Cervical Epithelium, Cervical Intraepithelial Neoplasia and Cervical Cancer.

Ikegami

Kato

1996

Acta Histochem. Cytochem

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Patterns of Keratin Subsets in Normal and Abnormal Uterine Cervical Tissues An Immunohistochemical Study

Cited by 6 publications

References 0 publications

Increased Expression of Cytokeratins 14, 18 and 19 Correlates with Tumor Progression in the Uterine Cervix

Increased Expression of Cytokeratins 14, 18 and 19 Correlates with Tumor Progression in the Uterine Cervix

Expression of CD10 and Cytokeratins in Ovarian and Renal Clear Cell Carcinoma

Keratin Expression in Normal Cervical Epithelium, Cervical Intraepithelial Neoplasia and Cervical Cancer.

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