1992
DOI: 10.1093/genetics/132.4.1105
|View full text |Cite
|
Sign up to set email alerts
|

Patterns of interallelic divergence at the rabbit b-locus of the immunoglobulin light chain constant region are in agreement with population genetical evidence for overdominant selection.

Abstract: Population studies at the b-locus of the "constant" regions of the rabbit immunoglobulin kappa 1 light chain (c kappa 1) revealed patterns of gene diversity resembling those that mark the peculiar nature of the major histocompatibility complex, such as large number of alleles, high heterozygosity levels, consistent excess of heterozygous individuals and long allele coalescence times. This paper documents the evolutionary patterns at the b-locus as inferred from DNA sequence comparisons. Among alleles, synonymo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
1
0

Year Published

1993
1993
2015
2015

Publication Types

Select...
5
1

Relationship

1
5

Authors

Journals

citations
Cited by 12 publications
(1 citation statement)
references
References 46 publications
0
1
0
Order By: Relevance
“…In spite of this extreme degree of Genetics 1 3 4 171-187 (August, 1993) interallelic divergence, genome analyses have confirmed the rabbit b locus allotypes as true alleles of a single-gene locus (EMORINE et al 1984;MATTHYSSENS et al 1985). The analysis of the patterns of nucleotide substitutions at b locus genes revealed close analogies to those reported for MHC loci, at both the qualitative and quantitative level (VAN DER Loo and VERDOODT 1992). According to NEI and coworkers, such patterns constitute evidence for overdominant selection NEI 1988, 1989; TAKAHATA, SATTA and KLEIN 1992).…”
mentioning
confidence: 90%
“…In spite of this extreme degree of Genetics 1 3 4 171-187 (August, 1993) interallelic divergence, genome analyses have confirmed the rabbit b locus allotypes as true alleles of a single-gene locus (EMORINE et al 1984;MATTHYSSENS et al 1985). The analysis of the patterns of nucleotide substitutions at b locus genes revealed close analogies to those reported for MHC loci, at both the qualitative and quantitative level (VAN DER Loo and VERDOODT 1992). According to NEI and coworkers, such patterns constitute evidence for overdominant selection NEI 1988, 1989; TAKAHATA, SATTA and KLEIN 1992).…”
mentioning
confidence: 90%