Patterns of Innovation in Alzheimer’s Disease Drug Development: A Strategic Assessment Based on Technological Maturity

Beierlein, Jennifer M.; McNamee, Laura M.; Walsh, Michael J.; Ledley, Fred D.

doi:10.1016/j.clinthera.2015.07.003

Cited by 14 publications

(17 citation statements)

References 55 publications

(54 reference statements)

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“…Those technologies that did not exhibit an S-curve in this analysis exhibited an exponential growth pattern characteristic of nascent technologies, and none have generated approved NMEs. The characteristic patterns of technology growth and NME approvals observed in this study are similar to those we have observed in other studies including studies of drugs for Alzheimer’s disease and gene therapies[45, 49, 63], of which 80–90% of which exhibit the exponentiated logistic growth pattern that can be modeled with the TIME model.…”

Section: Discussionsupporting

confidence: 86%

“…The information value of any single publication may vary in magnitude ranging from large advances that contribute positively to knowledge, to incremental, inconsequential, or even incorrect (negative) contributions. However, when integrated over very large numbers of publications, the cumulative number of publications provides a quantifiable metric for the accumulation of knowledge[45, 63]. …”

Section: Methodsmentioning

confidence: 99%

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Modeling timelines for translational science in cancer; the impact of technological maturation

McNamee

Ledley

2017

PLoS ONE

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This work examines translational science in cancer based on theories of innovation that posit a relationship between the maturation of technologies and their capacity to generate successful products. We examined the growth of technologies associated with 138 anticancer drugs using an analytical model that identifies the point of initiation of exponential growth and the point at which growth slows as the technology becomes established. Approval of targeted and biological products corresponded with technological maturation, with first approval averaging 14 years after the established point and 44 years after initiation of associated technologies. The lag in cancer drug approvals after the increases in cancer funding and dramatic scientific advances of the 1970s thus reflects predictable timelines of technology maturation. Analytical models of technological maturation may be used for technological forecasting to guide more efficient translation of scientific discoveries into cures.

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Section: Discussionsupporting

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Modeling timelines for translational science in cancer; the impact of technological maturation

McNamee

Ledley

2017

PLoS ONE

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“…Most technological developments follow and S-shaped growth curve, that can be divided into four phases: pre-development, take-off, acceleration, and stabilization [64][65][66]. Therefore, the study cases uses a sigmoid function g(t, x) to adjust the power network growth data [67]:…”

Section: Methodsmentioning

confidence: 99%

Anthropization and Growth of the Electricity Grid as Variables for the Analysis of Urban Infrastructure

et al. 2020

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City growth goes together with the development of infrastructure, and the power network is one of the most relevant towards economic development. The study of urban infrastructure through the analysis of anthropization coupled with power network growth can produce a tool that supports sustainable infrastructure planning, both economic and environmental. The case study focuses on Ambato, Ecuador, in the period from 1950 to 2019, and assesses quantitatively the changes in the city layout and the evolution of its power network. The data are adjusted to a sigmoid-type objective function through a non-linear least squares problem, that is solved using the Broyden-Fletcher-Goldfarb-Shanno (BFGS) method. Anthropization data show how the urban area grew during the study period: at the expense of agricultural land. The forecast for new power network users by 2050 yields a result of 203,630 total users with a population density of 4850 people/km 2 . The conclusion is that this type of analysis can help city planners and decision makers further understand city and infrastructure growth dynamics and produce policies that bolster sustainable city growth.Sustainability 2020, 12, 1486 2 of 17 multi-family), but also the service networks, including the power network. However, most modern Latin American cities have experienced a fragmented urban growth, through lots and suburbs, often under speculative pressure and unplanned self-construction as new land is made available and has access to service infrastructure [5].Documenting the growth of a city can be very useful if the drawings are made with further purpose than observing formal chronological aspects of the architectural background [6]. Adding other backgrounds and variables to cross evaluate and analyse gives a better understanding of unforeseen growth tendencies and brings up otherwise hidden deficiencies of the urban service networks in the different areas of the city. This information is very valuable when establishing sustainable urban planning criteria [7,8], Herce and Miró Farellons suggest five development lines to reformulate urban models from a sustainability standpoint [9]. These include relating service infrastructure with land use in order to increase efficiency.The study of anthropization together with infrastructure growth is an essential tool to assess the state of a city and determine actions to bolster its sustainability based on economic parameters (economic accessibility, production, private sector, public services, jobs); environmental parameters (agriculture, water, air, energy, environmental management, resources, waste, noise); social parameters (quality of life, environmental education, population, identity, social inclusion, participation, safety, and health); and urban parameters (equipment, street furniture, green areas, planning and management, land, transportation) [10][11][12]. In this context, urban infrastructure includes transportation networks, fresh water and sewers networks, power network, and information network, as well as the managemen...

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“…The second type of factors is about technology fields [3,[61][62][63]. Technology innovations, updates and applications were the central support for the progress of industrialization.…”

Section: Challenges In Industrializationmentioning

confidence: 99%

Positioning and Priorities of Growth Management in Construction Industrialization: Chinese Firm-Level Empirical Research

Zhang

Xie

2017

Sustainability

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Abstract:The purpose of this research is to quantitatively evaluate the growth phase, position, and priorities of the industrialization policy management of the construction industry at firm level. The goal is to integrate quantitative dynamics into the policy-making process for sustainable policy development in future China. This research proposes an integrated framework, including growth management model and industrial policy evaluation method, to identify the challenges of construction industrialization and policy management. The research applies the mixed system method, which includes entropy method and average score method, to analyze the growth stage and major impact indexes targeting 327 survey samples. The empirical results show that the proposed conceptual framework and policy evaluation method could effectively determine the growth position and directions of the construction industrialization. For verification purpose, the study uses the local industry data from Shaanxi Province, China. The calculation results substantiate that the construction industry is in the middle section of the third growth phase. The comparison of the results from statistical methods shows that the local construction industry still needs substantial effort in policy management to improve its sustainable industrialization level. As countermeasures, the policy priorities should concentrate on: (1) enhancing effective cooperation among universities, research institutions and enterprises; (2) improving actions towards technology transfer into productivity; and (3) encouraging market acceptance of construction industrialization. This research complements the existing literature of policy evaluation of construction industrialization. Moreover, it provides theoretical and operational steps on industry policy evaluation and growth management framework, with accurate and ample data analysis on firm-level survey. Researchers and policy makers can use this research for further extensions of policy management for construction industrialization.

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Patterns of Innovation in Alzheimer’s Disease Drug Development: A Strategic Assessment Based on Technological Maturity

Cited by 14 publications

References 55 publications

Modeling timelines for translational science in cancer; the impact of technological maturation

Modeling timelines for translational science in cancer; the impact of technological maturation

Anthropization and Growth of the Electricity Grid as Variables for the Analysis of Urban Infrastructure

Positioning and Priorities of Growth Management in Construction Industrialization: Chinese Firm-Level Empirical Research

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