Patterns of Hypocapnia on Tilt in Patients with Fibromyalgia, Chronic Fatigue Syndrome, Nonspecific Dizziness, and Neurally Mediated Syncope

Naschitz, Jochanan E.; Mussafia-Priselac, R; Kovalev, Yulia; Zaigraykin, Natalia; Slobodin, Gleb; Elias, Nizar; Rosner, Itzhak

doi:10.1097/00000441-200606000-00001

Cited by 17 publications

(16 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…About half of the individuals with POTS exhibit orthostatic hyperventilation and hypocapnia, while the other half breathe normally and are eucapnic (Stewart et al, 2006). A similar respiratory pattern of orthostatic hypocapnia has been noted in about a third of CFS subjects (Naschitz et al, 2000, 2006; Natelson et al, 2007). …”

Section: Orthostatic Stress Impairs Cognitive Performance In Cfssupporting

confidence: 70%

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Ocon¹

2013

Front. Physiol.

View full text Add to dashboard Cite

Chronic Fatigue Syndrome (CFS) is defined as greater than 6 months of persistent fatigue that is experienced physically and cognitively. The cognitive symptoms are generally thought to be a mild cognitive impairment, but individuals with CFS subjectively describe them as “brain fog.” The impairment is not fully understood and often is described as slow thinking, difficulty focusing, confusion, lack of concentration, forgetfulness, or a haziness in thought processes. Causes of “brain fog” and mild cognitive impairment have been investigated. Possible physiological correlates may be due to the effects of chronic orthostatic intolerance (OI) in the form of the Postural Tachycardia Syndrome (POTS) and decreases in cerebral blood flow (CBF). In addition, fMRI studies suggest that individuals with CFS may require increased cortical and subcortical brain activation to complete difficult mental tasks. Furthermore, neurocognitive testing in CFS has demonstrated deficits in speed and efficiency of information processing, attention, concentration, and working memory. The cognitive impairments are then perceived as an exaggerated mental fatigue. As a whole, this is experienced by those with CFS as “brain fog” and may be viewed as the interaction of physiological, cognitive, and perceptual factors. Thus, the cognitive symptoms of CFS may be due to altered CBF activation and regulation that are exacerbated by a stressor, such as orthostasis or a difficult mental task, resulting in the decreased ability to readily process information, which is then perceived as fatiguing and experienced as “brain fog.” Future research looks to further explore these interactions, how they produce cognitive impairments, and explain the perception of “brain fog” from a mechanistic standpoint.

show abstract

Section: Orthostatic Stress Impairs Cognitive Performance In Cfssupporting

confidence: 70%

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Ocon¹

2013

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…Hyperventilation (and its objective measure, hypocapnia) reduces serum CO 2 , a common feature of fibromyalgia syndrome (FMS)' (Naschitz et al 2006). Hypocapnia (reduced levels of CO 2 , regarded as the objective measure of hyperventilation), was diagnosed in 9-27% of patients with fibromyalgia, CFS and dizziness, as compared with between 0% and 2% of control subjects.…”

Section: Hyperventilation and Fmsmentioning

confidence: 99%

Conditions associated with fibromyalgia

Chaitow

2010

Fibromyalgia Syndrome

View full text Add to dashboard Cite

“…In a study of healthy women and men, Croft et al (1994) found a correlation between TTP counts and psychological distress. Hyperventilation (and its objective measure, hypocapnia, reduced serum CO 2 ) is associated with fibromyalgia (Naschitz et al, 2006), and progesterone encourages hyperventilation and hypocapnia during the luteal phase of a normal menstrual cycle (Slatkovska et al, 2006). HPA axis dysfunction may blunt endogenous analgesia pathways, such as the endorphin system and endocannabinoid systems.…”

Section: Article In Pressmentioning

confidence: 99%

The diagnosis of fibromyalgia in women may be influenced by menstrual cycle phase

Dunnett

Roy

Stewart

et al. 2007

Journal of Bodywork and Movement Therapies

View full text Add to dashboard Cite

Patterns of Hypocapnia on Tilt in Patients with Fibromyalgia, Chronic Fatigue Syndrome, Nonspecific Dizziness, and Neurally Mediated Syncope

Cited by 17 publications

References 38 publications

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Conditions associated with fibromyalgia

The diagnosis of fibromyalgia in women may be influenced by menstrual cycle phase

Contact Info

Product

Resources

About