Patterns of Healthcare Utilization Leading to Diagnosis of Young-Onset Colorectal Cancer (yCRC): Population-Based Case-Control Study

Farooq, Ameer; Brown, Carl J; Sayre, Eric C.; Raval, Manoj J.; Loree, Jonathan M.; Garg, Ria; Vera, Mary A. De

doi:10.3390/cancers14174263

Cited by 3 publications

(2 citation statements)

References 17 publications

(29 reference statements)

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“…Authors: Vienna Cheng, PharmD 1,2 ; Eric C. Sayre, PhD 3 ; Vicki Cheng, PharmD 1,2 ; Ria Garg, PharmD 4 ; Sharlene Gill, MD, MPH, MBA, FRCPC 5,6 ; Ameer Farooq, MD, MPH, FRCSC 7 ; Mary A. De Vera, PhD 1,2,8 Affiliations:…”

Section: Title: Patterns Of Prescription Medication Use Before Diagno...mentioning

confidence: 99%

“…We drew rationale for evaluating the 1-year period before diagnosis from Pottegard et. al's study showing marked prescription drug use 6 months before cancer diagnosis and from our own prior work with patterns of outpatient physician visits the year before cancer diagnosis [5]. By law, prescriptions dispensed from community pharmacies in British Columbia must be entered in PharmaNet, a province-wide network [15].…”

Section: Prescription Medication Usementioning

confidence: 99%

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Patterns of Prescription Medication Use Before Diagnosis of Early Age-Onset Colorectal Cancer: Population-Based Descriptive Study

Cheng,

Sayre,

Cheng

et al. 2024

JMIR Cancer

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Background: Colorectal cancer (CRC) is estimated to be the fourth major cancer diagnosis in Canada (except for non-melanoma skin cancers) and the second and third leading cause of cancer-related death in males and females, respectively. Objective:The rising incidence of early age-onset colorectal cancer (EAO-CRC; diagnosis at <50 years), calls for better understanding of patients' pathway to diagnosis. We evaluated patterns of prescription medication use before EAO-CRC diagnosis. Methods:We used linked administrative health databases in British Columbia, Canada to identify cases diagnosed with EAO-CRC between 01/01/2010 to 12/31/2016, along with cancer-free controls (1:10), matched on age and sex. We identified all prescriptions dispensed from community pharmacies during the year prior to diagnosis and used the Anatomical Therapeutic Chemical (ATC) Classification system Level 3 to group prescriptions according to drug class. We conducted a parallel assessment for those diagnosed with average age-onset CRC (AAO-CRC; diagnosis at age ?50 year). Results:We included 1,001 EAO-CRC cases (41.0 ± 6.1 years; 45% females), 12,989 prescriptions were filled in the year before diagnosis by 797 individuals (79.7%). Top filled drugs were antidepressants (1st; 13.1%). Drugs for peptic ulcer disease and gastroesophageal reflux disease (3rd; 6.1%) were more likely filled by EAO-CRC cases than controls (OR 1.4, 95% CI, 1.2 to 1.7) and with more frequent fills (OR 1.8, 95% CI, 1.7 to 1.9). We noted similar patterns for topical agents for hemorrhoids and anal fissures which were more likely filled by EAO-CRC cases than controls (OR 7.4, 95% CI, 5.8 to 9.4) and with more frequent fills (OR 15.6, 95% CI, 13.1 to 18.6). Conclusions:We observed frequent prescription medication use in the year before diagnosis of EAO-CRC, including for drugs to treat commonly reported symptoms of EAO-CRC.

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Section: Title: Patterns Of Prescription Medication Use Before Diagno...mentioning

confidence: 99%

Section: Prescription Medication Usementioning

confidence: 99%

Patterns of Prescription Medication Use Before Diagnosis of Early Age-Onset Colorectal Cancer: Population-Based Descriptive Study

Cheng,

Sayre,

Cheng

et al. 2024

JMIR Cancer

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“It's Probably Just Hemorrhoids”: A Qualitative Exploration of the Lived Experiences and Perceptions of Long-term Survivors of Early-Onset Colorectal Cancer

Rogers,

Korous,

De Vera

et al. 2023

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Colorectal cancer (CRC) among adults aged <50 years (early-onset CRC [EOCRC]) is projected to be the leading cause of cancer-related death by 2030. Although evidence-based guidelines for CRC screening now recommend beginning screening at age 45, the needs of many at-risk young adults are potentially being overlooked. Unanswered questions also remain regarding the effects of EOCRC on quality-of-life and psychosocial outcomes. This qualitative study explored the lived experiences and perceptions of a sample of adult EOCRC survivors in the United States through one-on-one interviews. Methods: An EOCRC advocate survivor team (AST) member led 27 structured virtual interviews using a 10-question interview guide. Data were analyzed using a 9-step inductive approach. Results: Participants were geographically diverse. Most were women (66.6%) who self-identified as non-Hispanic White (85.2%). The mean age at interview was 40.19 ± 5.99; at diagnosis, 33.93 ± 5.90. Six overarching themes emerged: signs and symptoms, risk factors, system-level factors, quality of life, social support, and reflection. Conclusions: The specific needs of individuals in this younger population of CRC patients should be considered during treatment and future interventions and throughout survivorship. Impact: While the reasons for the increasing incidence of EOCRC are currently unknown, the lived experiences and perceptions of EOCRC survivors noted in this study highlight specific needs of this population that can inform educational materials, comprehensive care, future research, and policy change.

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Patterns of Prescription Medication Use Before Diagnosis of Early Age-Onset Colorectal Cancer: Population-Based Descriptive Study (Preprint)

Cheng,

Sayre,

Cheng

et al. 2023

Preprint

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BACKGROUND Colorectal cancer (CRC) is estimated to be the fourth major cancer diagnosis in Canada (except for non-melanoma skin cancers) and the second and third leading cause of cancer-related death in males and females, respectively. OBJECTIVE The rising incidence of early age-onset colorectal cancer (EAO-CRC; diagnosis at <50 years), calls for better understanding of patients’ pathway to diagnosis. We evaluated patterns of prescription medication use before EAO-CRC diagnosis. METHODS We used linked administrative health databases in British Columbia, Canada to identify cases diagnosed with EAO-CRC between 01/01/2010 to 12/31/2016, along with cancer-free controls (1:10), matched on age and sex. We identified all prescriptions dispensed from community pharmacies during the year prior to diagnosis and used the Anatomical Therapeutic Chemical (ATC) Classification system Level 3 to group prescriptions according to drug class. We conducted a parallel assessment for those diagnosed with average age-onset CRC (AAO-CRC; diagnosis at age ≥50 year). RESULTS We included 1,001 EAO-CRC cases (41.0 ± 6.1 years; 45% females), 12,989 prescriptions were filled in the year before diagnosis by 797 individuals (79.7%). Top filled drugs were antidepressants (1st; 13.1%). Drugs for peptic ulcer disease and gastroesophageal reflux disease (3rd; 6.1%) were more likely filled by EAO-CRC cases than controls (OR 1.4, 95% CI, 1.2 to 1.7) and with more frequent fills (OR 1.8, 95% CI, 1.7 to 1.9). We noted similar patterns for topical agents for hemorrhoids and anal fissures which were more likely filled by EAO-CRC cases than controls (OR 7.4, 95% CI, 5.8 to 9.4) and with more frequent fills (OR 15.6, 95% CI, 13.1 to 18.6). CONCLUSIONS We observed frequent prescription medication use in the year before diagnosis of EAO-CRC, including for drugs to treat commonly reported symptoms of EAO-CRC.

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Patterns of Healthcare Utilization Leading to Diagnosis of Young-Onset Colorectal Cancer (yCRC): Population-Based Case-Control Study

Cited by 3 publications

References 17 publications

Patterns of Prescription Medication Use Before Diagnosis of Early Age-Onset Colorectal Cancer: Population-Based Descriptive Study

Patterns of Prescription Medication Use Before Diagnosis of Early Age-Onset Colorectal Cancer: Population-Based Descriptive Study

“It's Probably Just Hemorrhoids”: A Qualitative Exploration of the Lived Experiences and Perceptions of Long-term Survivors of Early-Onset Colorectal Cancer

Patterns of Prescription Medication Use Before Diagnosis of Early Age-Onset Colorectal Cancer: Population-Based Descriptive Study (Preprint)

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