Patterns of healthcare utilization and costs for vascular dementia in a community-dwelling population

Hill, Jerrold; Fillit, Howard; Shah, Sonali; Valle, Megan C. del; Futterman, Robert

doi:10.3233/jad-2005-8105

Cited by 50 publications

(47 citation statements)

References 22 publications

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“…In contrast to depression and anxiety, the relationship between schizophrenia and cardiovascular morbidity and mortality is less clear [9,21,27]; nonetheless, patients treated for schizophrenia present an increased rate of new-onset diabetes and metabolic syndrome when compared with the general population [12,18,22]. In particular, effective management of chronic illnesses in patients with dementia represents a current clinical challenge [19,43].…”

Section: Introductionmentioning

confidence: 99%

Do Psychiatric Comorbidities Influence Inpatient Death, Adverse Events, and Discharge After Lower Extremity Fractures?

Menendez

Neuhaus

Bot

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Background Psychiatric comorbidity is known to contribute to illness (the state of feeling unwell/unable to rely on one's body) and increased use of healthcare resources, but the effect on inpatient outcomes in fracture care is relatively unexplored. Questions/purposes Our primary null hypothesis is that a concomitant diagnosis of depression, anxiety, dementia, or schizophrenia is not associated with (1) discharge to another care facility rather than home after lower extremity fractures. Secondary study questions address the associations between psychiatric comorbidity and (2) longer inpatient stay and inpatient (3) adverse events; (4) blood transfusion; and (5) mortality after lower extremity fractures. Methods Using the National Hospital Discharge Survey database, we analyzed a total estimated number of 10,669,449 patients with lower limb fractures from 1990 to 2007. Sixty-four percent were women, and the mean ± SD age was 67 ± 22 years. The prevalence in the study population was 3.2% for depression, 1.6% for anxiety, 0.6% for schizophrenia, and 2.9% for dementia. Results A discharge diagnosis of psychiatric comorbidity was associated with a lower rate of discharge to home after accounting for an association with greater medical comorbidity (schizophrenia: odds ratio [OR], 5.6, 95% confidence interval [CI], 5.5-5.8; dementia: OR, 1.3, 95% CI, 1.2-1.3; depression: OR, 1.2, 95% CI, 1.2-1.3; anxiety: OR, 1.04, 95% CI, 1.02-1.06). Hospital stay was longer for patients with schizophrenia and dementia but shorter in patients with depression or anxiety compared with patients without any mental disorders. Schizophrenia was associated with more in-hospital adverse events and depression and anxiety with fewer events. A diagnosis of depression was associated with blood transfusion. Psychiatric comorbidity was not associated with a higher risk of in-hospital death.

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Section: Introductionmentioning

confidence: 99%

Do Psychiatric Comorbidities Influence Inpatient Death, Adverse Events, and Discharge After Lower Extremity Fractures?

Menendez

Neuhaus

Bot

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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“…In 2002, the estimated prevalence of VaD among individuals aged 71 years and older in the USA was 2.4%, compared to 9.7% for AD [1] . Similar to AD, the public health burden of VaD threatens to worsen considerably as the world's population ages [2] .…”

Section: Introductionmentioning

confidence: 99%

Association between APOE ε4 Allele and Vascular Dementia: The Cache County Study

Chuang

Hayden

Norton

et al. 2010

Dement Geriatr Cogn Disord

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Background: The APOE Ε4 allele is an established risk factor for Alzheimer’s disease, but reports of its association with vascular dementia (VaD) have been inconsistent. We examined the relationship between APOE Ε4 allele and the risk of incident VaD in a large, population-based cohort of elderly adults with up to 10 years of follow-up between 1995 and 2005. Methods: A total of 3,424 elderly men and women free of dementia were genotyped at the baseline assessment. Incident VaD was identified through standardized procedures administered at 3 follow-up assessments. Cox proportional hazards models were used to evaluate the risk of VaD associated with APOE Ε4. Results: The adjusted hazard ratio was 1.6 for the participants with 1 APOE Ε4 allele (95% CI: 0.9–2.7; p = 0.083) and 4.4 for those with 2 APOE Ε4 alleles (95% CI: 1.6–12.5; p = 0.005). The increased risk did not appear to be mediated by vascular risk factors. Conclusions: The APOE Ε4 allele is associated with an increased risk of VaD in a dose-dependent fashion and accounts for almost 20% of VaD in the population.

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“…It was also concluded that an apoA-I mimetic peptide could significantly reduce the inflammation of brain arterioles and significantly improve cognitive function in this mouse model (Buga 2006). In light of the fact that vascular dementia afflicts approximately 15% of Americans 65 years of age or older-second only to Alzheimer's disease as the leading cause of dementia-and in the Medicare population has cost that are twice that of Alzheimer's management in the Ambulatory settings (Hill 2005). Current shortcomings exist in effective outpatient management that could ultimately reduce morbidity and healthcare costs.…”

Section: Apolipoprotein Mimetic Peptides In a Mouse Model Of Brain Armentioning

confidence: 92%

The Effect of Apolipoprotein Mimetic Peptides in Inflammatory Disorders Other Than Atherosclerosis

Navab

Anantharamaiah

Fogelman

2008

Trends in Cardiovascular Medicine

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Patterns of healthcare utilization and costs for vascular dementia in a community-dwelling population

Cited by 50 publications

References 22 publications

Do Psychiatric Comorbidities Influence Inpatient Death, Adverse Events, and Discharge After Lower Extremity Fractures?

Do Psychiatric Comorbidities Influence Inpatient Death, Adverse Events, and Discharge After Lower Extremity Fractures?

Association between APOE ε4 Allele and Vascular Dementia: The Cache County Study

The Effect of Apolipoprotein Mimetic Peptides in Inflammatory Disorders Other Than Atherosclerosis

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