Patterns of Ethanol Intake in Preadolescent, Adolescent, and Adult Wistar Rats Under Acquisition, Maintenance, and Relapse‐Like Conditions

Garcia‐Burgos, David; González, Félix María Pedreira; Manrique, Tatiana; Gallo, M.

doi:10.1111/j.1530-0277.2008.00889.x

Cited by 47 publications

(37 citation statements)

References 22 publications

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“…Vetter-O'Hagen et al (2009), using a 2 h limited-access to ethanol model, found that the ethanol consumed varied as a function of sex and age, although the sex differences that emerged at each age were opposites: adolescent males consumed more ethanol than both the adolescent and adult females, while in adulthood, echoing the data in the previous paragraph, the females consumed more ethanol than the males. Nevertheless, it should be noted that not all studies point to these differences in sex, as in the findings obtained by García-Burgos et al (2009), using a 24 h unlimited-access to ethanol model. While their results do seem to indicate a greater consumption of ethanol in adolescent rats, they suggested no difference by sex.…”

Section: Introductionmentioning

confidence: 85%

Sex differences in adult Wistar rats in the voluntary consumption of ethanol after pre-exposure to ethanol-induced flavor avoidance learning

Torre

Escarabajal

Zapata

2015

Pharmacology Biochemistry and Behavior

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Section: Introductionmentioning

confidence: 85%

Sex differences in adult Wistar rats in the voluntary consumption of ethanol after pre-exposure to ethanol-induced flavor avoidance learning

Torre

Escarabajal

Zapata

2015

Pharmacology Biochemistry and Behavior

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“…The neglect of adolescence, in rodents ranging approximately from 3 to 7 weeks of age (Adriani et al 2002;Laviola et al 2003;Spear 2000), is especially surprising, given the demonstrated relevance of this phase in the development of a number of neuropsychiatric pathologies (Paus et al 2008). For example, adolescents have a marked propensity to develop risk-and drug-taking behaviors and this propensity also appears in rat (Doremus-Fitzwater and Spear 2007;Garcia-Burgos et al 2009;Maldonado et al 2008;Ristuccia and Spear 2008;Varlinskaya and Spear 2004a, b) and mouse (Hefner and Holmes 2007;Itzhak and Anderson 2008;Linsenbardt et al 2008;Stevenson et al 2008;Tambour et al 2008) models. In addition, different psychopharmacological profiles have been described between the pre-pubertal/early (*4 weeks), peri-adolescent (*6 weeks), and adult stages (Adriani et al 2002;Laviola et al 2003;Spear 2000;Spear and Brake 1983).…”

Section: Introductionmentioning

confidence: 93%

Strain-Dependent Changes in Acoustic Startle Response and its Plasticity Across Adolescence in Mice

Pietropaolo

Crusio

2009

Behav Genet

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Acoustic startle response and its plasticity, e.g., habituation and prepulse inhibition (PPI), have been extensively investigated, being altered in several neuropsychiatric disorders. Yet, little is known about the expression of startle-related behaviors during adolescence, a critical phase in the development of a variety of major neuropsychiatric pathologies. The present study investigated for the first time startle behaviors across adolescence in male mice of the inbred strains C57BL/6J and DBA/2J. Pre-pubertal (4 weeks of age) mice displayed reduced startle reactivity and altered PPI compared to adult animals (8 weeks of age), but these effects were observed only in the C57BL/6J strain. Strain differences were also clearly detected for startle response, habituation, and PPI. All effects were modulated by the intensity of the pulse stimulus and were not confounded by differences in anxiety levels. Our data demonstrate that genetic factors and the early adolescent phase are critically important considerations in the design of mouse models of neuropsychiatric disturbances.

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“…Rat alcohol consumption peaks at night in a light/dark cycle [111]. In mice, alcohol is more intoxicating at night than during the day, and genetic knockout of Per2 eliminates this differential sensitivity, leading to overall increases in alcohol intake across the 24 hr cycle [112].…”

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confidence: 99%

Circadian Clock and Stress Interactions in the Molecular Biology of Psychiatric Disorders

Landgraf

McCarthy

Welsh

2014

Curr Psychiatry Rep

144

100

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Many psychiatric disorders are characterized by circadian rhythm abnormalities including disturbed sleep/wake cycles, changes in locomotor activity, and abnormal endocrine function. Animal models with mutations in circadian "clock genes" commonly show disturbances in reward processing, locomotor activity and novelty seeking behaviors, further supporting the idea of a connection between the circadian clock and psychiatric disorders. However, if circadian clock dysfunction is a common risk factor for multiple psychiatric disorders, it is unknown if and how these putative clock abnormalities could be expressed differently, and contribute to multiple, distinct phenotypes. One possible explanation is that the circadian clock modulates the biological responses to stressful environmental factors that vary with an individual's experience. It is known that the circadian clock and the stress response systems are closely related: Circadian clock genes regulate the physiological sensitivity to, and rhythmic release of glucocorticoids (GC). In turn, GCs have reciprocal effects on the clock. Since stressful life events or increased vulnerability to stress are risk factors for multiple psychiatric disorders including posttraumatic stress disorder (PTSD), attention deficit hyperactivity disorder (ADHD), bipolar disorder (BD), major depressive disorder (MDD), alcohol use disorder (AUD) and schizophrenia (SCZ), we propose that modulation of the stress response is a common mechanism by which circadian clock genes affect these illnesses. Presently, we review how molecular components of the circadian clock may contribute to these six psychiatric disorders, and present the hypothesis that modulation of the stress response may constitute a common mechanism by which the circadian clock affects multiple psychiatric disorders.

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Patterns of Ethanol Intake in Preadolescent, Adolescent, and Adult Wistar Rats Under Acquisition, Maintenance, and Relapse‐Like Conditions

Cited by 47 publications

References 22 publications

Sex differences in adult Wistar rats in the voluntary consumption of ethanol after pre-exposure to ethanol-induced flavor avoidance learning

Sex differences in adult Wistar rats in the voluntary consumption of ethanol after pre-exposure to ethanol-induced flavor avoidance learning

Strain-Dependent Changes in Acoustic Startle Response and its Plasticity Across Adolescence in Mice

Circadian Clock and Stress Interactions in the Molecular Biology of Psychiatric Disorders

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