Patterns of endothelium-dependent circulation reactions development in patients with ischemic stroke in case of oxigenation disturbances

Abstract

Aim. To study features of tissue oxygenation and changes in nitroxidergic and endothelinergic mechanisms of circulation regulation in ischemic stroke and hypoxia modeling.
 Methods. 74 men and women with ischemic stroke were examined and experimental study on 30 outbred white male rats was conducted. All patients underwent computed tomography of the brain, neurological status was assessed and general clinical examination was performed. Tissue oxygen tension was measured percutaneuosly using polarographic method. Chronic hypoxic hypoxia was simulated in animals by daily 40-50 minutes inhalation of 10% oxygen mixture for 4 weeks. Blood oxygen tension was evaluated in patients and laboratory animals. Nitric oxide level of was assessed by determining its stable metabolites. Endothelin-1 level was determined by ELISA. Data was analyzed using «Statistica 8.0» software using non-parametric tests. Differences were considered as statistically significant at p