Patterns of distant metastases in vulvar cancer

Woelber, Linn; Haeringer, N; Eulenburg, Christine; Donata, G.; Trillsch, Fabian; Burandt, Eike; Schmalfeldt, Barbara; Mahner, Sven; Mueller, Volkmar

doi:10.26226/morressier.5770e29ed462b80290b4c8fa

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“…Additional studies over six months may be necessary to observe serum Hb A1c levels and if the effects if diet are sustainable. The present report similar results as two other studies [36,37]. It is consistent with current guidelines advising people with prediabetic and diabetic conditions to lose weight [38,39].…”

Section: Discussionsupporting

confidence: 93%

Impact of an Okinawa/Nordic based diet on endocrinological and periodontal conditions in individuals with type 2 diabetes. A case-control study

Persson

Widén

Wohlfart

et al. 2023

Preprint

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Objectives To assess if the results following intake of a diet using an Okinawan-based Nordic diet (OBND) over one month differs in endocrinological, periodontal clinical outcome, and serum cytokine levels compared to a standard hospital care diet in individuals with diabetes type 2 (T2D)(control group)Background Scientific evidence suggests that the use of diet for individuals with T2D may be beneficial.Methods Participating individuals with T2D were randomly assigned to a test (OBND)(n = 14), or control group (n = 16). Anthropometric data, blood glucose levels, HbA1c levels, lipids, serum inflammation markers (CRP, and a routine panel of 24 cytokines), blood pressure, gingival bleeding on probing (BOP), probing pocket depths (PPD), and clinical attachment levels (CAL) were studied.Results Statistical analyses of baseline study data failed to demonstrate study group differences. The mean weight reduction was greater in the OBND group (4.1 kg) versus the control group (1.3 kg) (p < 0.01). The reduction in BMI was 1.4 kg/m2 in OBND (p < 0.001) and 0.5 kg/m2 in the control group, respectively (p < 0.01). Diastolic and systolic blood pressure reductions were greater in the OBND group than in the control group (p < 0.01). Periodontal study parameters (BOP % scores) and (PPD values) decreased (p < 0.001) overall with no between group differences. The OBND resulted in reduction of serum levels of IFNγ, Eotaxin IL-9, IP10,IL17a, MCP-1,m and PDFBB compared to the control diet.Conclusions A strict T2D- diet provides an association between reduction in serum HbA1c and BOP scores. Serum levels decreases in IFNγ, Eotaxin IL-9, IP-10, IL17a. MCP-1, and PDFBB were only found in the test group.

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Section: Discussionsupporting

confidence: 93%