Antimicrobial resistant infections cause approximately 700,000 deaths globally each year. The development of resistance is influenced by the frequency of antibiotic use. This article describes an international antimicrobial stewardship competency framework for international undergraduate nurse education and how this framework can be mapped into nurse education programmes. A case study is used to demonstrate how the competencies apply to nursing practice. Key points • Antimicrobial resistant infections cause approximately 700,000 deaths globally each year and the development of resistance is influenced by the frequency of antibiotic use. • Antimicrobial stewardship (AMS), i.e. the safe and effective use of antibiotics, should results in the best clinical outcome for the treatment or prevention of infection, with minimal toxicity to the patient and minimal impact on subsequent resistance • Nurses are directly involved in stewardship activities, are increasingly prescribers of antibiotics, and their role in AMS is reinforced in national and international policy, however, few have heard of the term AMS. • A competency framework, comprising 63 individual competency descriptors essential for AMS in nursing practice, that supports current and future standards of proficiency for registered nurses, has been developed and endorsed by scientific and professional bodies including The National Institute for Health and Care Excellence (NICE), providing a baseline with regards to the minimum standard required of nurses.