Patterns of Cortical Oxygen Saturation Changes During CO ₂ Reactivity Testing in the Vicinity of Cerebral Arteriovenous Malformations

Abstract

Background and Purpose-The aim of this study was to test the hypothesis that patterns of cerebrovascular reactivity (CVR) in the vicinity of cerebral arteriovenous malformations (AVMs) before and after resection are not specific for this disease. Methods-With

Analysing the response in R2* relaxation rate of intracranial tumours to hyperoxic and hypercapnic respiratory challenges: initial results

“…Further studies are needed to better define typical patterns in different tumour entities and to determine the potential role of this method in therapy planning and monitoring. An intra-operative correlation [51] and a direct comparison with histopathology in specific tumour regions would improve the understanding of the measured R2* changes.…”

Dynamic Autoregulation Testing Does Not Indicate Changes of Cerebral Blood Flow Before and After Resection of Small- and Medium-Sized Cerebral AVM

“…Both notions have been criticized mainly because the methodology and algorithm used allowed for only crude estimates of CBF regulation. Yet their results were later confirmed by others with more refined methods [5,19]. Still the question remained whether state-of-the-art assessment of dynamic AR components as described above might be capable of showing subtle disturbances.…”

Perinidal Angiogenesis Is a Predictor for Neurovascular Uncoupling in the Periphery of Brain Arteriovenous Malformations: A Task‐Based and Resting‐State fMRI Study

“…These dysplastic vessels are thought to have impaired vasoactivity, thus aggravating the disruption of local neurovascular coupling. It should be noted that the mechanisms of AVM‐related NVU remains relatively unclear, and the changes of CVR in AVMs reported in the literature are not conclusive 36 . Therefore, future research with breath‐hold CVR mapping is needed to verify the correlation of NVU, CVR, and the presence of PA.…”

“…4,35 PA usually not only communicates with the nidus but connects to normal capillaries, arterioles, and venules. 8 The prolonged state of hemodynamic overload 36 Therefore, future research with breath-hold CVR mapping is needed to verify the correlation of NVU, CVR, and the presence of PA. Constituting the blood-brain barrier, astrocytes, pericytes, and endothelial cells have been proved to play crucial roles in preserving healthy neurovascular coupling.…”