Patterns of Comorbidities in Psoriasis Patients: A Cross-Sectional Study

Abstract

Background: Psoriasis is a chronic, inflammatory, and immune-mediated dermatological disease of unknown etiology with predominant involvement of the skin, nails, and joints. This study aimed to assess comorbidities patterns in psoriasis patients. Methods: This is a cross-sectional study conducted at King Abdulaziz Medical City (KAMC) in Jeddah, Saudi Arabia. Data were collected through a retrospective chart review of the electronic medical record system (Bestcare, Ezcaretech, Seoul, Korea) and by utilizing a structured data collection sheet. Results: A total of 128 confirmed psoriasis cases were included with a mean age of 44.2 ± 17.3. The sample had 45.7% females and 54.3% males. Nearly half the patients (46.1%) had no comorbidities, followed by those who had at least one comorbidity (24.2%) and those who had two or more comorbidities (29.7%). Most patients were classified as plaque psoriasis (57.0%), followed by those who had psoriatic arthritis (13.3%). There was no statistical significance between gender, body mass index (BMI), and smoking with the number of comorbidities (P= 0.422, P=0.361, P=0.772); 41.2% of psoriatic arthritis patients and all erythrodermic arthritis patients had two or more comorbidities, which is statistically significant at p -value <0.018. Conclusion: This study demonstrated the prevalence of different comorbidities associated with psoriasis patients; 41.2% of psoriatic arthritis patients and all erythrodermic arthritis patients had two or more comorbidities, which was statistically significant. This necessitates closer monitoring of different comorbidities a psoriasis patient might present with. Especially those who are diagnosed with psoriatic arthritis and erythrodermic arthritis.

Epidemiology and Cutaneous Manifestations of Psoriasis in Saudi Arabia: A Narrative Review

“…Another, most recent cross-sectional study by Alajmi et al from Jeddah (western region) reported 33.6% unidentified psoriasis. 27 The majority of patients, however, were diagnosed with plaque psoriasis (57.0%), followed by those with psoriatic arthritis (13.3%). There were only a few cases of nail psoriasis (0.8%), pustular psoriasis (1.6%), and inverse psoriasis (1.6%).…”

“…Alajmi et al 2021 27 Jeddah Out of 128 confirmed psoriasis cases, plaque psoriasiswas diagnosed in 57.0%, followed by those with psoriatic arthritis at 13.3%. There were only a few cases of nail psoriasis (0.8%), pustular psoriasis (1.6%), and inverse psoriasis (1.6%).…”

“…There were only a few cases of nail psoriasis (0.8%), pustular psoriasis (1.6%), and inverse psoriasis (1.6%). 27 Various local studies have also reported the prevalence of other types of psoriasis involving different sites among Saudis. (Table 2) These studies warrant further investigation for controlling psoriasis and psoriasis-related cutaneous manifestations in Saudi Arabia.…”

A retrospective analysis of comorbidities in patients with psoriasis at a single centre

“…Psoriasis can affect individuals of all age groups. Studies in Nigeria and India indicated that the majority of their samples belonged to the fourth decade [ 11 ]. In this study, the highest age distribution was observed among patients aged between 31 and 60 years old (54.1%).…”

Phenotypes of Psoriasis in Patients in Need of Systemic Treatment, and Correlation with Personal Habits, Treatment History and Comorbidities: A Cross-sectional Latent Class Analysis of Data from the Italian PsoReal Registry

“…Furthermore, a treatment resistant course and a smaller drug survival of biologics could be hypothesized, as already described by others ( 8 ). The high rate of comorbidities in erythrodermic PsO is well known ( 9 ). PsA, hypertension and kidney disease were remarkably more prevalent in LC5 compared with other classes.…”