Patterns of childhood-onset uveitis in a referral center in Turkey

Özdal, Pınar; Şen, Emine; Yazıcı, Alper; Öztürk, Faruk

doi:10.1007/s12348-011-0044-8

Cited by 46 publications

(25 citation statements)

References 21 publications

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“…These ndings are also supported by the fact that toxoplasmosis-associated uveitis, the most common cause of posterior and infectious uveitis, was observed more frequently in Turkey. 13,27 In contrast, our study results reported that only 1.9% of cases were posterior uveitis; this is probably due to the less incidence of infectious uveitis in Korean children.…”

Section: Discussioncontrasting

confidence: 55%

“…In addition, as shown in Table 4, relatively high proportions of panuveitis were reported in Turkey, Japan, and Israel (18.2%, 28.1%, and 30.8%, respectively). 1,16,27 These countries also reported a relatively high prevalence of Behçet disease-associated uveitis, which usually presents as panuveitis. Although it is well known that the anatomical locations of uveitis vary by region and race, one reason for these differences may include variability in the prevalence of other systemic diseases that cause uveitis by region and race.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of pediatric uveitis and associated systemic diseases

Shin

Kang

Lee

et al. 2020

Preprint

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Background: The early detection of uveitis associated with systemic inflammatory disease in children is important for proper treatment and prognosis. However, the diagnosis may be delayed because of difficulties in childhood examinations and early minor systemic symptoms. The objective of our study was to identify the pattern of childhood uveitis and investigate the frequency and clinical features of rheumatic diseases in pediatric patients with uveitis. Methods: This retrospective observational study reviewed the medical records of children (age ≤18 years) with uveitis at a Korean tertiary hospital between January 2005 and December 2018. Data collected included the age at onset of uveitis, sex, anatomic location of ocular inflammation, comorbid disease (including systemic inflammatory disease), ocular complications, relevant laboratory data, and treatment. Fisher’s exact test was used to compare categorical variables and the Mann–Whitney U test was used to compare continuous variables. A p-value of <0.05 was considered statistically significant. Results: A total of 155 pediatric patients with uveitis were included in this study. The median age at diagnosis was 13.0 years (interquartile range, 9.5–16.0 years). The male-to-female ratio was 1.09. The process was unilateral in 51.6% of children. Anterior uveitis, panuveitis, intermediate uveitis, and posterior uveitis represented 51.6%, 26.5%, 6.5%, and 1.9% of the cases, respectively. Idiopathic uveitis (65.2%) was the most frequent type of uveitis. Systemic rheumatic disease associations were responsible for 28.4% of the cases, among which juvenile idiopathic arthritis (JIA) was the most frequent cause (14.8%). Human leukocyte antigen (HLA)-B27 and antinuclear antibody (ANA) positive rates were significantly higher in patients with JIA than in those with idiopathic uveitis (p=0.006 and p=0.007, respectively). Conclusions: Approximately one-third of children with uveitis in Korea have a systemic rheumatic disease, of which JIA accounts for the majority of cases. HLA-B27 and ANA can be useful screening tools in children with JIA-associated uveitis.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Epidemiology of pediatric uveitis and associated systemic diseases

Shin

Kang

Lee

et al. 2020

Preprint

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“…Durch die retrospektive Analyse der Krankenblätter konnten in unserer Studie epidemiologische und krankheitsspezifische Daten ermittelt werden, die in wesentlichen Aspekten den bereits publizierten Beobachtungen zu Art und Schweregrad der Uveitis bei Kindern und Jugendlichen entsprechen. In Übereinstimmung mit früheren Publikationen waren die Patienten in unserer Studie vorrangig weiblichen Geschlechts, mit frühem Erkrankungsalter in der ersten Lebensdekade, einer hohen Komplikationsrate, einer häufigen Assoziation mit der juvenilen idiopathischen Arthritis und der häufigen Verwendung von DMARDs [4,[16][17][18][19].…”

Section: Sozialmedizinische Folgen Der Uveitisunclassified

Sozialmedizinische Folgen bei Uveitis im Kindes- und Jugendalter: Ergebnisse einer Pilotstudie

Böttner

Mussinghoff

Hörste

et al. 2017

Klin Monatsbl Augenheilkd

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Chronic illness - such as uveitis - may lead to socio-economic consequences, and poorer quality of life. To study the influence of uveitis on quality of life and professional development. Prospective evaluation of juvenile patients with uveitis (age < 18 years, classification of uveitis as in Standardization of Uveitis Nomenclature [SUN] criteria, duration of disease ≥ 12 months) seen in a tertiary referral centre. Influence of uveitis on quality of life, recreational activities, educational training and development of severe disability were analysed. Results were correlated to clinical data, and analysed by descriptive statistics. 39 patients of 49 (80 %) had anterior uveitis (69.4 % in both eyes), of which 34 (69 %) presented with associated systemic disease (juvenile idiopathic arthritis, n = 28). 33 (80 %) had developed complications caused by uveitis. 15 patients (31 %) had undergone ophthalmic surgery due to these complications. Many patients were treated with conventional (n = 37; 76 %) and biological (n = 18; 37 %) disease-modifying antirheumatic drugs (DMARDs). In 41 % of the cases, quality of life and recreational time (23 %) were markedly reduced. Sick leave from pre-school or school because of uveitis (mean 12.5 days/year; 15 %> 20 days) was recorded in 32 patients (65 %). Uveitis negatively influenced school education in 29 %, and resulted in the necessity to repeat class (n = 3) or to change school (n = 3). Severe disability due to uveitis was found in 30 % of the patients. Uveitis in childhood and adolescence may have a substantial impact on social and professional perspectives. Uveitis may result in severe disability even in early childhood.

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“…6,7 In Turkey, JIA and Behçet’s disease are the most common systemic diseases among pediatric uveitis cases, and the reported incidence of JIA varies between 3.3% and 30.4%. 8,9,10,11 …”

Section: Introductionmentioning

confidence: 99%

Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis

Oray¹,

Tuğal-Tutkun²

2016

tjo

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Pediatric uveitis may be a serious health problem because of the lifetime burden of vision loss due to severe complications if the problem is not adequately treated. Juvenile idiopathic arthritis (JIA)-associated uveitis is characterized by insidious onset and potentially blinding chronic anterior uveitis. Periodic ophthalmologic screening is of utmost importance for early diagnosis of uveitis. Early diagnosis and proper immunomodulatory treatment are essential for good visual prognosis. The goal of treatment is to achieve enduring drug-free remission. The choice of therapeutic regimen needs to be tailored to each individual case. One must keep in mind that patients under immunomodulatory treatment should be monitored closely due to possible side effects. Local and systemic corticosteroids have long been the mainstay of therapy; however, long-term corticosteroid therapy should be avoided due to serious side effects. Steroid-sparing agents in the treatment of JIA-associated uveitis include antimetabolites and biologic agents in refractory cases. Among the various immunomodulatory agents, methotrexate is generally the first choice, as it has a well-established safety and efficacy profile in pediatric cases and does not appear to increase the risk of cancer. Other classic immunomodulators that may also be used in combination with methotrexate include azathioprine, mycophenolate mofetil, and cyclosporin A. Biologic agents, primarily tumor necrosis factor alpha inhibitors including infliximab or adalimumab, should be considered in cases of treatment failure with classic immunomodulatory agents.

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Patterns of childhood-onset uveitis in a referral center in Turkey

Cited by 46 publications

References 21 publications

Epidemiology of pediatric uveitis and associated systemic diseases

Epidemiology of pediatric uveitis and associated systemic diseases

Sozialmedizinische Folgen bei Uveitis im Kindes- und Jugendalter: Ergebnisse einer Pilotstudie

Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis

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