Patterns of care and survival outcomes in patients with astroblastoma: an individual patient data analysis of 152 cases

Mallick, Supriya; Benson, Rony; Venkatesulu, BhanuPrasad; Melgandi, Wineeta; Rath, G.K.

doi:10.1007/s00381-017-3410-5

Cited by 16 publications

(29 citation statements)

References 62 publications

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“…In this study, we retrospectively characterized a series of 14 adults and 1 adolescent with centrally reviewed ABM. The present cohort shares characteristics with previous published studies with ABM being a supratentorial tumor with a clear female predominance and heterogeneous clinical courses. Comprehensive interrogation of genetic alterations in these 15 patients (including methylation profiling, targeted DNA sequencing, RNA sequencing, RT‐PCR, and qPCR) allowed reclassification of cases in three subgroups (PXA‐like ABM, HGG‐like ABM, and ABM with MN1‐BEND2 fusion) with distinct radiological and histological features as well as clinical outcomes.…”

Section: Discussionsupporting

confidence: 79%

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Molecular Profiling Reclassifies Adult Astroblastoma into Known and Clinically Distinct Tumor Entities with Frequent Mitogen-Activated Protein Kinase Pathway Alterations

et al. 2019

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Background. Astroblastoma (ABM) is a rare glial brain tumor. Recurrent meningioma 1 (MN1) alterations have been recently identified in most pediatric cases. Adolescent and adult cases, however, remain molecularly poorly defined. Materials and Methods. We performed clinical and molecular characterization of a retrospective cohort of 14 adult and 1 adolescent ABM. Results. Strikingly, we found that MN1 fusions are a rare event in this age group (1/15). Using methylation profiling and targeted sequencing, most cases were reclassified as either pleomorphic xanthoastrocytomas (PXA)-like or high-grade glioma (HGG)-like. PXA-like ABM show BRAF mutation (6/7 with V600E mutation and 1/7 with G466E mutation) and CD34 expression. Conversely, HGG-like ABM harbored specific alterations of diffuse midline glioma (2/5) or glioblastoma (GBM; 3/5). These latter patients showed an unfavorable clinical

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Section: Discussionsupporting

confidence: 79%

“…It was first described in 1926 by Bailey and Cushing and further characterized by Bailey and Bucy in 1930. ABM is generally regarded as an entity occurring in children and young adults . However, in a recent epidemiological survey, 56% of cases were diagnosed after 30 years of age .…”

Section: Introductionmentioning

confidence: 99%

Molecular Profiling Reclassifies Adult Astroblastoma into Known and Clinically Distinct Tumor Entities with Frequent Mitogen-Activated Protein Kinase Pathway Alterations

et al. 2019

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“…The clinical manifestations of astroblastoma tend to correlate with the raised intracranial pressure caused by the tumor, which in turn depend on the size, mass and localization of the tumor and may vary significantly among the individual patients. Typically, astroblastoma develop in the cerebral hemispheres, most likely affecting the frontal lobe followed by parietal and temporal lobes [ 2 ]. Nevertheless, such tumors has also been reported at other locations of the central nervous system, like the corpus callosum, cerebellum, brainstem, intraventricular or cauda equine [ 5 18 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Astroblastoma is an uncommon brain tumor of glial origin, with typical manifestation in the young age, although few congenital cases have also been described [ 1 2 3 ]. In general, astroblastomas are large, peripheral and solid (with occasional cystic component) brain tumors.…”

Section: Introductionmentioning

confidence: 99%

Astroblastoma in a Young Female Patient: A Case Report and Literature Review of Clinicopathological, Radiological and Prognostic Characteristics and Current Treatment Strategies

Sadiq

Ahmad

Shuja

et al. 2017

Brain Tumor Res Treat

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Astroblastoma is an uncommon glial tumor with predominant manifestation in the young age. Herein, we report a case of 18-year-old astroblastoma female patient who presented with history of two months headache. Magnetic resonance imaging (MRI) of the brain demonstrated well circumscribed, intra-axial abnormal signal intensity lesion (size=5×4 cm2) in the right parieto-occipital region of the brain. The patient underwent complete surgical resection of the gross tumor, as confirmed by an early post-surgical MRI (i.e., within 24 hours of surgery). Histopathological examination revealed neoplastic lesion exhibiting perivascular pseudo-rosettes with centrally hyalinized blood vessel and focal nuclear pleomorphism. Immunohistochemistry staining illustrated reactivity for glial fibrillary acidic protein and integrase interactor 1 (INI-1). These features rendered the diagnosis of astroblastoma. A comprehensive review of the current literature to summarize the clinicopathological and radiological characteristics, prognostic factors and current treatment strategies of astroblastomas is also presented. Our study would expand the pool of this uncommon tumor towards its better understanding and optimal treatment.

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“…1 It usually affects children and young adults, with a slight prevalence in females. 2,3 According to the World Health Organization (WHO) Classification of Tumors of the CNS, astroblastoma is defined as a neoplasm composed of cells that "have broad, non-or slightly tapering processes radiating towards central blood vessels" (astroblastic pesudorosettes). 3 Due to the histological similarity to other tumors, which also feature peri-vascular rosettes (e.g.…”

Section: Introductionmentioning

confidence: 99%

Extra‐axial anaplastic astroblastoma in a 67‐year‐old woman

et al. 2019

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Astroblastoma is a rare glial neoplasia of the central nervous system. It is histologically defined by the presence of neoplastic cells with non-or slightly tapering processes arranged around blood vessels (astroblastic rosettes) and conventionally subdivided into well-differentiated and anaplastic. It commonly affects children and young adults, although cases and due to its superficial location in the brain cortex, it can mimic an extra-axial mass on magnetic resonance imagining. Herein, we describe a unique case of pure extra-axial anaplastic astroblastoma in an elderly woman. Awareness that astroblastoma may be also extra-axial and affect older subjects, may be helpful for its identification and differential diagnosis toward more common entities at this site and age of onset, and for appropriate therapeutic management as well.

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Patterns of care and survival outcomes in patients with astroblastoma: an individual patient data analysis of 152 cases

Abstract: AB has two distinct grades with higher-grade tumors having significantly poor survival. Maximal safe surgery followed by adjuvant radiation and temozolomide should be advocated for these tumors.

Cited by 16 publications

References 62 publications

Molecular Profiling Reclassifies Adult Astroblastoma into Known and Clinically Distinct Tumor Entities with Frequent Mitogen-Activated Protein Kinase Pathway Alterations

Molecular Profiling Reclassifies Adult Astroblastoma into Known and Clinically Distinct Tumor Entities with Frequent Mitogen-Activated Protein Kinase Pathway Alterations

Astroblastoma in a Young Female Patient: A Case Report and Literature Review of Clinicopathological, Radiological and Prognostic Characteristics and Current Treatment Strategies

Extra‐axial anaplastic astroblastoma in a 67‐year‐old woman

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