Patterns of canine gastric electrical activity

Ka, Kelly; Cf, Code; Lr, Elveback

doi:10.1152/ajplegacy.1969.217.2.461

Cited by 164 publications

(108 citation statements)

References 2 publications

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“…Canine fundus circular muscle exhibited no spontaneous, myogenic electrical activity; but, in contrast, the region from the orad corpus to the pyloric ring did show spontaneous activity. Previous studies using extracellular electrodes in vivo have pointed out such differences (Kelly et al 1969;Weber & Kohatsu, 1970;Kelly & Code, 1971 (Sugawara, 1964;Kelly & Code, 1971). In such experiments, the frequency proximal to the transaction was the same as before the transaction (5/min) whereas distally the frequency fell.…”

Section: Discussionmentioning

confidence: 98%

Intracellular electrical activity of canine and human gastric smooth muscle.

El-Sharkawy¹,

Morgan²,

Szurszewski³

1978

The Journal of Physiology

157

116

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SUMMARY1. Intracellular recordings were obtained from circular smooth muscle fibres of the canine fundus, corpus, antrum and pylorus as well as from the human corpus and antrum.2. In the canine stomach, all regions of the stomach except the fundus exhibited spontaneous action potentials.3. The spontaneous action potential consisted of an upstroke potential and a plateau potential.4. There were regional differences in the configuration of the plateau potential. Corporal and antral smooth muscle did not normally spike during the plateau potential whereas terminal antral and pyloric muscle usually showed spikes on top of the plateau potential. Near the intermediate sphincter, there was a zone of transition in which oscillations in potential of variable amplitude were superimposed on the plateau potential.5. The configuration of the action potential of the human stomach was similar to the configuration of the canine action potential when the same region of the stomach was compared.6. The ionic dependence of the plateau potential was studied in canine stomach in an area where neither oscillations nor spikes occurred.7. In calcium-free solution, all spontaneous activity stopped. D600 selectively suppressed the size of the plateau potential.8. Sodium-deficient solution reduced the size of the plateau potential. 9. These results suggest that both calcium and sodium may be involved as current carriers in the generation of the plateau potential.

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Section: Discussionmentioning

confidence: 98%

Intracellular electrical activity of canine and human gastric smooth muscle.

El-Sharkawy¹,

Morgan²,

Szurszewski³

1978

The Journal of Physiology

157

116

View full text Add to dashboard Cite

show abstract

“…The localization of points of initiation of slow waves has been investigated in the intact stomach of dog using extracellular electrodes; the observations indicated that the "pacemaker site" shifted at times [51]. Later, it is reported that the rhythmic activity first appeared in the corpus and then propagated successively to pyloric regions across the antrum [52]. However, re-examination of the points of initiation of myogenic activity in the dog stomach revealed that activity started from variable regions and occasionally propagated in an "antidromic" direction [53].…”

Section: Properties Of Spontaneous Activity In Gastric Smooth Musclesmentioning

confidence: 99%

Cellular Mechanisms of Myogenic Activity in Gastric Smooth Muscle.

Suzuki

2000

JJP

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Many types of smooth muscle contract spontaneously, with each contraction being accompanied by a slow rhythmic oscillation of the membrane potential (slow wave), a discharge of spike potentials or both [1]. The spontaneous generation of a single spike or bursts of spikes is detected in smooth muscles of the urinary bladder, the uterus (longitudinal muscle layer), the prostate, the isolated longitudinal muscle of the intestine or the portal vein. Slow waves are observed in smooth muscle of the stomach, the circular layer of the intestine and uterus of many species, the renal pelvis, the urethra and the ureter. In several of these muscles, spike potentials are followed. These include the renal pelvis, ureter, uterus (circular muscle), lymphatic vessels and the urethra [2]. As many enteric nerves generate bursts of activity, the transmitters released from these nerves can modulate the activity of smooth muscles [3], and there is a possibility that smooth muscle activity could result indirectly as a consequence of neuronal activity. However, this is rarely the cause of muscle activity since many smooth muscles remain active after neuronal activity has been that ICC may also be the pacemaker cells responsible for gastric activity. However, isolated circular smooth muscle tissues spontaneously generate regenerative potentials, suggesting that there are at least two sites for the initiation of spontaneous activity in the stomach. Regenerative potentials persist in the presence of Ca-antagonists and are inhibited by agents which disrupt intracellular Ca 2ϩ homeostasis. Depolarization of the membrane elicits regenerative potentials after a long delay and the potentials have long refractory periods. This suggests that an unidentified 2nd messenger may be formed during the delay between membrane depolarization and the initiation of a regenerative potential. In gastric muscles of mutant mice which do not express inositol trisphosphate (InsP 3 ) receptors, spike potentials but not slow waves are generated, suggesting the possible involvement of InsP 3 in the initiation of spontaneous activity.

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“…Propagated wavefronts are observed in the gastric musculature with multichannel serosal or intraluminal electrodes. 3,4 Current research strongly implicates interstitial cells of Cajal (ICCs) as the originators of GEA with smooth muscle cells passively propagating the activity. 5 Abnormal GEA has not been well studied.…”

Section: Introductionmentioning

confidence: 99%

Biomagnetic detection of gastric electrical activity in normal and vagotomized rabbits

Bradshaw

Myers

Redmond

et al. 2003

Neurogastroenterology Motil

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We recorded the vector magnetogastrogram (MGG) due to gastric electrical activity (GEA) in normal rabbits using a Superconducting QUantum Interference Device (SQUID) magnetometer and measured the degree of correlation of the MGG with 24 channels of serosal electrodes. The vector magnetometer allows us to non-invasively record three orthogonal magnetic field components and project the recorded magnetic field vector into arbitrary directions. We optimized the magnetic field vector direction to obtain the highest possible correlation with each serosal electrode recording. We performed a vagotomy and examined spatial and temporal changes in the serosal potential and in the transabdominal magnetic field. We obtained spatial information by mapping the recorded signals to the electrode positions in the gastric musculature. Temporal evidence of uncoupling was observed in spectral analyses of both serosal electrode and SQUID magnetometer recordings. We conclude that non-invasive recordings of the vector magnetogastrogram reflect underlying serosal potentials as well as pathophysiological changes following vagotomy.

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Patterns of canine gastric electrical activity

Cited by 164 publications

References 2 publications

Intracellular electrical activity of canine and human gastric smooth muscle.

Intracellular electrical activity of canine and human gastric smooth muscle.

Cellular Mechanisms of Myogenic Activity in Gastric Smooth Muscle.

Biomagnetic detection of gastric electrical activity in normal and vagotomized rabbits

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