Patterns of antenatal corticosteroid prescribing 1998–2004

Polyakov, Alex; Cohen, Saul L.; Baum, Marita; D, Trickey; Jolley, Damien; Wallace, Euan M.

doi:10.1111/j.1479-828x.2006.00677.x

Cited by 44 publications

(31 citation statements)

References 14 publications

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“…Fetal arterial pressure and heart rate (HR) were recorded for 1 h on 131 and 132 days of gestation (dGA); fetal HR was derived from the arterial pressure waveform. After arterial pressure was recorded at 131 dGA, betamethasone (5.7 mg im, Celestone Chronodose, Schering-Plough) was administered to the ewe, as the majority of preterm infants are exposed to exogenous corticosteroids before birth (31). Fetal arterial blood was sampled each day following surgery for analysis of blood gases (ABL800, Radiometer, Denmark) and other markers of fetal physiological status.…”

Section: Methodsmentioning

confidence: 99%

Sex differences in cardiorespiratory transition and surfactant composition following preterm birth in sheep

Ishak

Hanita

Sozo

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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Male preterm infants are at greater risk of respiratory morbidity and mortality than females but mechanisms are poorly understood. Our objective was to identify the basis for the "male disadvantage" following preterm birth using an ovine model of preterm birth in which survival of females is greater than males. At 0.85 of term, fetal sheep underwent surgery (11 female, 10 male) for the implantation of vascular catheters to monitor blood gases and arterial pressure. After cesarean delivery at 0.90 of term, lambs were monitored for 4 h while spontaneously breathing; lambs were then euthanized and static lung compliance measured. We analyzed surfactant phospholipid composition in amniotic fluid and in bronchoalveolar lavage fluid (BALF) taken at necropsy; we also analyzed surfactant protein (SP) expression in lung tissue. Before delivery male fetuses tended to have lower pH (P = 0.052) compared with females. One hour after delivery, males had significantly lower pH and higher arterial partial pressure of CO(2) (Pa(CO(2))), lactate, glucose, and mean arterial pressure than females. Two males died 1 h after birth. Static lung compliance was 37% lower in males than females (P < 0.05). In BALF, males had significantly more protein, a lower percentage of the phosphatidylcholine (PC) 32:0 (dipalmitoylphosphatidylcholine) and higher percentages of PC34:2 and PC36:2. There were no sex-related differences in lung architecture or expression of SP-A, -B, -C, and -D. The lower lung compliance in male preterm lambs compared with females may be due to altered surfactant phospholipid composition and function. These changes may compromise gas exchange and impair respiratory adaptation after male preterm birth.

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Section: Methodsmentioning

confidence: 99%

Sex differences in cardiorespiratory transition and surfactant composition following preterm birth in sheep

Ishak

Hanita

Sozo

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Maternal administration of antenatal steroids promotes surfactant production and maturation of the fetal lung. 14,15 Exogenous administration of the surfactant has been proven effective in prophylactic and rescue treatment of respiratory distress syndrome in premature infants.…”

Section: Neonatal Cardio-respiratory Adaptationmentioning

confidence: 99%

Congenital lung lesions: Postnatal management and outcome

Parikh

Rasiah

2015

Seminars in Pediatric Surgery

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“…Our lamb model of preterm birth includes antenatal betamethasone administration to the ewe because the majority of preterm infants in developed countries will be exposed to antenatal corticosteroids (21).…”

Section: Bensley Et Almentioning

confidence: 99%

Preterm birth with antenatal corticosteroid administration has injurious and persistent effects on the structure and composition of the aorta and pulmonary artery

et al. 2011

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INTRODUCTION:Preterm birth affects 8-12% of live births and is associated with the development of elevated arterial blood pressure and aortic narrowing in later life; this suggests that preterm birth may alter the development of arteries. Our objective was to determine the effects of preterm birth, accompanied by antenatal corticosteroid administration, on the structure of the aorta and pulmonary artery, which experience different alterations in pressure flow at birth. RESULTS: at 11 wk, preterm lambs had significantly thicker aortic walls and a smaller lumen, whereas the morphometry of the pulmonary artery was unaffected. elastin deposition was markedly increased in the aorta and pulmonary artery and smooth muscle content was reduced in the aorta only. In preterm lambs we found injury in the aorta only; controls were unaffected. DISCUSSION: We conclude that moderate preterm birth after antenatal betamethasone can cause injury and persistent alterations in the structure and composition of the aorta, with lesser effects in the pulmonary artery. Our findings suggest that preterm birth may increase the risk of atherosclerosis and aortic aneurysms in later life. METHODS:Using an established ovine model of preterm birth, lambs were born at 0.9 of gestation and underwent necropsy at 11 wk after birth; controls were born at term.

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Patterns of antenatal corticosteroid prescribing 1998–2004

Abstract: Increasing numbers of women birthing after 34 weeks in our hospital are receiving antenatal corticosteroids before 34 weeks. The long-term implications of this are not currently clear.

Cited by 44 publications

References 14 publications

Sex differences in cardiorespiratory transition and surfactant composition following preterm birth in sheep

Sex differences in cardiorespiratory transition and surfactant composition following preterm birth in sheep

Congenital lung lesions: Postnatal management and outcome

Preterm birth with antenatal corticosteroid administration has injurious and persistent effects on the structure and composition of the aorta and pulmonary artery

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