Patterns of Alcohol Consumption Among Individuals With Alcohol Use Disorder During the COVID-19 Pandemic and Lockdowns in Germany

Deeken, Friederike; Reichert, Markus; Zech, Hilmar; Wenzel, Julia; Wedemeyer, Friederike; Aguilera, Alvaro; Aslan, Acelya; Bach, Patrick; Bahr, Nadja S.; Ebrahimi, Claudia; Fischbach, Pascale C.; Ganz, Marvin; Garbusow, Maria; Großkopf, Charlotte M.; Heigert, Marie; Hentschel, Angela; Karl, Damian; Pelz, Patricia; Pinger, Mathieu; Riemerschmid, Carlotta; Rosenthal, Annika; Steffen, Johannes; Strehle, Jens; Weiss, Franziska; Wieder, Gesine; Wieland, Alfred; Zaiser, Judith; Zimmermann, Sina; Walter, Henrik; Lenz, Bernd; Deserno, Lorenz; Smolka, Michael N.; Liu, Shuyan; Ebner‐Priemer, Ulrich W.; Heinz, Andreas; Rapp, Michael A.; Romanczuk-Seiferth, Nina; Ströhle, Andreas; Bermpohl, Felix; Heim, Christine; Beck, Anne; Tost, Heike; Banaschewski, Tobias; Kiefer, Falk; Meyer‐Lindenberg, Andreas; Beste, Christian; Endraß, Tanja; Kiebel, Stefan J.; Kirschbaum, Clemens; Marxen, Michael; Nagel, Wolfgang E.; Pilhatsch, Maximilian; Stock, Ann‐Kathrin; Arndt, Viktoria; Belanger, Matthew J.; Chen, Hao; Frölich, Sasha; Ghin, Filippo; Neumer, Caroline; Schwöbel, Sarah; Gan, Gabriela; Schwarz, Kristina; Kunas, Stefanie L.; Stuke, Heiner

doi:10.1001/jamanetworkopen.2022.24641

Cited by 13 publications

(18 citation statements)

References 31 publications

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“…This finding may be due to a larger odds ratio for binge drinking during the weekend days versus weekdays of 10.34 in the Martel et al (22) than in our sample with 2.18. The higher binge drinking probability and more work in the home office during the COVID-19 pandemic may lie at the bottom of the observed smaller differences between weekend days and weekdays (39).…”

Section: Discussionmentioning

confidence: 94%

“…Moreover, we used general linear mixed models to evaluate the effects of menstrual cycle phases on the progesterone/estradiol ratios as an outcome variable. The number of fulfilled AUD criteria and weekend days versus weekdays were included in these models, since these parameters are associated with alcohol use in our sample (39). To account for hormonal variations over the day, we also included the time of blood collection in the mixed models.…”

Section: Discussionmentioning

confidence: 99%

“…Between February 2020 and July 2022, we screened 3,492 individuals, and of these, 672 females and males with mainly mild-to-moderate AUD were enrolled at three study sites in Germany (Charité -Universitätsmedizin Berlin, Technische Universität Dresden, and Central Institute of Mental Health (CIMH) Mannheim; TRR265 cohort; preregistration: DRKS00020580). The study design included four visits (baseline and follow-ups scheduled at 4, 8, and 12 months after enrollment) and real-life Ecological Momentary Assessments (EMA) every other day (39). The project was approved by the local ethics committees of Charité -Universitätsmedizin Berlin, Technische Universität Dresden, and Heidelberg University.…”

Section: Study Design and Sample Descriptionmentioning

confidence: 99%

“…Participants were asked to submit information through a smartphone e-diary application every second day (for further details see (39)). They were reminded by an alarm at noon, which could be postponed until 8 PM.…”

Section: Data Sampling: Ecological Momentary Assessmentmentioning

confidence: 99%

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Progesterone/Estradiol Ratio Is Related to Real-Life Alcohol Consumption in Alcohol Use Disorder in a Sex- and Menstrual Cycle Phase-Dependent Manner

Hoffmann

Gerhardt

Mühle

et al. 2022

Preprint

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Background: Alcohol use disorder (AUD) is a critical public health issue with sex-specific characteristics and the need for a better mechanistic understanding. Initial evidence suggests that progesterone can reduce alcohol intake, while estradiol leads to an increase. However, we lack knowledge about how progesterone relative to estradiol influences alcohol use patterns in females and males with AUD. Methods: This multicenter within-subject study analyzed data on real-life alcohol use (21,438 intensively-sampled smartphone entries), menstrual cycle, and serum progesterone/estradiol ratios (677 blood samples) gathered during a 12-month follow-up in 74 naturally cycling females and 285 males with AUD (mean age: 29.7 and 37.8 years, respectively; data collection: 2020-2022). We used multilevel modelling to identify changes in alcohol use and progesterone/estradiol ratios across the menstrual cycle in females and associations between progesterone/estradiol ratios and alcohol use in males. Results: During the late luteal phase, females showed 0.6- to 0.8-fold lower (predicted) probabilities of binge drinking and 2.8- to 5.6-fold higher mean progesterone/estradiol ratios compared to the menstrual, follicular, and ovulatory phases. Similarly, in males, an increase of 10 units in the progesterone/estradiol ratio was related to 8 and 9% lower probabilities of binge drinking and any alcohol use, respectively. Conclusions: Based on ecologically valid results, this study reveals that higher progesterone/estradiol ratios can protect against problematic alcohol use in females and males with AUD. Therefore, the progesterone/estradiol ratio is a promising treatment target. Translated into clinical practice, our results also indicate that females with AUD may benefit from menstrual cycle phase-tailored treatments.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Study Design and Sample Descriptionmentioning

confidence: 99%

Section: Data Sampling: Ecological Momentary Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Progesterone/Estradiol Ratio Is Related to Real-Life Alcohol Consumption in Alcohol Use Disorder in a Sex- and Menstrual Cycle Phase-Dependent Manner

Hoffmann

Gerhardt

Mühle

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…This 12-month follow-up cohort study was conducted within the framework of the Collaborative Research Centre Transregio 265 (TRR265) (Heinz et al, 2020). Between The study design included four visits (baseline and follow-ups scheduled 4, 8, and 12 months after enrollment) accompanied by real-life Ecological Momentary Assessments (EMA; Deeken et al, 2022). The project was approved by the local ethics committees of Charité-Universitätsmedizin Berlin, Technical University Dresden, and Heidelberg University and written informed consent was obtained from all study participants.…”

Section: Designmentioning

confidence: 99%

Impulsiveness, Loneliness and Perceived Stress as Predictors of Alcohol Consumption in Alcohol Use Disorder Across the Lifespan

Rapp¹

2022

Preprint

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From adolescence to young adulthood to middle age, alcohol consumption (AC) varies across the lifespan. Here we show that the magnitude of the association of psychosocial variables predictive of AC and alcohol use disorder (AUD) varies as a function of age and gender. We examined the cross-sectional association of four psychosocial correlates (impulsiveness, stress, depression, and loneliness) of AC in 601 subjects (234 women and 367 men; aged 37.9 years ± 12.9 years; range 17 to 66 years) suffering from AUD from the TRR 265 cohort, controlling also for cognitive status (i.e., digit-symbol substitution). Due to collinearity of stress and depression, these two variables were transformed to their two principal components (indicating stress and depression versus coping). Specifically, we hypothesized and found impulsiveness to exhibit stronger associations in and young adults; for men the strong association also extended to early middle-aged adults. Likewise, the hypothesized effect of stress and depression significantly interacted with age and gender: for men, higher levels of stress and depression were associated with an increase of alcohol consumption, but this association decreased with age. For women, higher levels of stress and depression were associated with increased alcohol consumption only in late, but not in middle-age, and stress and depression were associated with decreased alcohol consumption in adolescent and young women. Counter to expectation and presumably due to a high correlation with stress and depression, there was no evidence for significant effects associated with loneliness in the multivariate model. There was evidence that coping was associated with a decrease in AC for participants with high and medium cognitive status. The prominent age- and gender related differences in psychosocial predictors of AC reveal that different behavioral mechanisms contribute to AC in men and women at different ages. Further research is needed to delineate the temporal dynamics of these predictor sets. Our results will directly inform more targeted preventive interventions in men and women of different age groups in the framework of the ReCoDe consortium.

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Understanding Alcohol Consumption and Its Antecedents and Consequences in Daily Life: The Why and the How

Reichert,

Brüßler,

Reichert

et al. 2024

Current Topics in Behavioral Neurosciences

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Patterns of Alcohol Consumption Among Individuals With Alcohol Use Disorder During the COVID-19 Pandemic and Lockdowns in Germany

Cited by 13 publications

References 31 publications

Progesterone/Estradiol Ratio Is Related to Real-Life Alcohol Consumption in Alcohol Use Disorder in a Sex- and Menstrual Cycle Phase-Dependent Manner

Progesterone/Estradiol Ratio Is Related to Real-Life Alcohol Consumption in Alcohol Use Disorder in a Sex- and Menstrual Cycle Phase-Dependent Manner

Impulsiveness, Loneliness and Perceived Stress as Predictors of Alcohol Consumption in Alcohol Use Disorder Across the Lifespan

Understanding Alcohol Consumption and Its Antecedents and Consequences in Daily Life: The Why and the How

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