Patterns, correlates, and barriers to medication adherence among persons prescribed new treatments for HIV disease.

Catz, Sheryl L.; Kelly, Jeffrey A.; Bogart, Laura M.; Benotsch, Eric G.; McAuliffe, Timothy L.

doi:10.1037/0278-6133.19.2.124

Cited by 595 publications

(470 citation statements)

References 36 publications

(42 reference statements)

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“…Self efficacy and depression were directly related to adherence, and self-efficacy was found to have a weak indirect relationship to adherence through its association with depression. These relationships lend further support to previous studies that have investigated both the role of self-efficacy and depression on medication adherence (Catz et al 2000;Gonzalez et al 2004;Kleeberger et al 2004). Moreover, the results provide support for self-efficacy theory.…”

Section: Discussionsupporting

confidence: 87%

“…Self-efficacious people are more successful in performing specific behaviors because they are more likely than others to persevere even under difficult situations until their goals are achieved. The results of several studies examining ART adherence support the relationship between self-efficacy and adherence in which higher levels of self-efficacy correspond to higher rates of ART adherence (Catz et al 2000;Gifford et al 2000;Tuldra et al 1999).…”

Section: Theoretical Perspectivementioning

confidence: 76%

“…For example, researchers have found that depression (Ammassari et al 2004;Kleeberger et al 2004;Sledjeski et al 2005) and low self-efficacy (Catz et al 2000;Godin et al 2005) contribute to low levels of reported adherence, and that having a good support system and positive attitudes (Catz et al 2000;Godin et al 2005) about medication taking foster adherence. While HIV adherence literature provides a good understanding of the personal and social variables that are most likely to play a role in ART adherence, the complexity of the interrelationships among these variables may be less well understood.…”

Section: Introductionmentioning

confidence: 99%

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Adherence to Antiretroviral Medication Regimens: A Test of a Psychosocial Model

et al. 2007

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Objective-The primary aim of this study was to test a psychosocial model of medication adherence among people taking antiretroviral medications. This model was based primarily on social cognitive theory and included personal (self-efficacy, outcome expectancy, stigma, depression, and spirituality), social (social support, difficult life circumstances), and provider (patient satisfaction and decision-making) variables. © Springer Science+Business Media, LLC 2007Correspondence to: Colleen DiIorio, cdiiori@sph.emory.edu. Design-The data for this analysis were obtained from the parent study, which was a randomized controlled trial (Get Busy Living) designed to evaluate an intervention to foster medication adherence. Factor analysis was used to develop the constructs for the model, and structural equation modeling was used to test the model. Only baseline data were used in this cross sectional analysis. NIH Public AccessMethods-Participants were recruited from a HIV/AIDS clinic in Atlanta, GA. Prior to group assignment, participants were asked to complete a questionnaire that included assessment of the study variables.Results-A total of 236 participants were included in the analysis. The mean age of the participants was 41 years; the majority were male, and most were African-American. In the final model, self-efficacy and depression demonstrated direct associations with adherence; whereas stigma, patient satisfaction, and social support were indirectly related to adherence through their association with either self-efficacy or depression.Conclusion-These findings provide evidence to reinforce the belief that medication-taking behaviors are affected by a complex set of interactions among psychosocial variables and provide direction for adherence interventions.

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Section: Discussionsupporting

confidence: 87%

Section: Theoretical Perspectivementioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

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Adherence to Antiretroviral Medication Regimens: A Test of a Psychosocial Model

et al. 2007

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“…For example, drug users continue to face discrimination from some medical providers who frequently treat them with distrust and disrespect (Chitwood, Sanchez, Comerford, & McCoy, 2001;Crofts, Louie, & Loff, 1997;Day, Ross, & Dolan, 2003;Edlin et al, 2001;Stephenson, 2001;Treloar, Hopwood, & Loveday, 1996;Zickmund, Hillis, Barnett, Ippolito, & LaBrecque, 2004). Also, despite the recent changes to the NIH guidelines regarding HCV treatment, many health care providers have historically been concerned that drug users treated for HCV might have a high risk of re-infection, low treatment compliance, and/or drug relapse (Catz, Kelly, Bogart, Benotsch, & McAuliffe, 2000;Golub et al, 2004;Gordillo, del Amo, Soriano, & Gonzalez-Lahoz, 1999;Hauser et al, 2002;Milby et al, 1996;Osher et al, 2003). In fact, recent research conducted by Morrill et al (2005) found that primary care physicians tended not to treat patients with a past history of substance abuse for their HCV infection.…”

Section: Discussionmentioning

confidence: 99%

Exploring drug users’ attitudes and decisions regarding hepatitis C (HCV) treatment in the U.S.

Munoz-Plaza

Strauß

Astone-Twerell

et al. 2008

International Journal of Drug Policy

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Individuals with a history of injecting drugs are at the highest risk of becoming infected with the hepatitis C virus (HCV), with studies of patients in methadone maintenance treatment programmes (MMTPs) reporting that 60-90% of intravenous drug users (IDUs) have the virus. Fortunately, HCV therapy has been shown to be effective in 42-82% of all patients with chronic HCV infection, including IDUs. While the decision to start HCV therapy requires significant consideration, little research exists that explores the attitudes of drug users toward HCV therapy. Therefore, this paper examines how drug users perceive the treatment, as well as the processes by which HCV-positive individuals examined the advantages and disadvantages of starting the HCV medications. Interviews were conducted with 164 patients from 14 drug treatment programmes throughout the United States, and both uninfected and HCV-positive drug users described a pipeline of communication among their peers that conveys largely negative messages about the medications that are available to treat HCV. Although many of the HCV-positive individuals said that these messages heightened their anxiety about the side effects and difficulties of treatment, some patients said that their peers helped them to consider and/or initiate HCV treatment. Gaining a better understanding of drug users' perceptions of HCV treatment is important, because so many of them, particularly IDUs, are already infected with HCV and may benefit from support in addressing their HCV treatment needs. In addition, currently uninfected drug users will likely remain at high risk for contracting HCV and may need to make decisions about whether or not to start the HCV medical regimen in the future.

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“…Although linking seropositive persons to care is an important goal in itself, increasing the proportion of infected individuals who are referred to and followup in care will also help to decrease rates of HIV transmission. Viral load is often decreased among persons who are linked to care and adhere to their treatment regimens (36,(77)(78)(79); lower viral load is associated with decreased rates of HIV transmission (38)(39)(40)(41).…”

Section: Shifting Context Of Hiv Testingmentioning

confidence: 99%

Effective Detection of HIV

Newman

Etzel

2000

Journal of Acquired Immune Deficiency Syndromes

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Summary: Biomedical advances, new HIV testing technologies, and policy shifts in the last 15 years have created substantial new challenges and opportunities for service providers, policy makers, and researchers regarding broad scale identification of HIVseropositive persons. Effective HIV testing will be achieved when we: (1) increase the number of high-risk persons tested; (2) decrease the time from HIV infection to detection; (3) increase testing acceptability; (4) increase the proportion of individuals tested who receive their results; and (5) increase the proportion of individuals tested seropositive who are linked to care. Strategies to enhance effectiveness include implementing new testing technologies and delivery modalities; expanding access to clientcontrolled testing; targeting providers' knowledge, attitudes, and behaviors regarding HIV testing; mainstreaming HIV testing as routine clinical care; targeting persons who engage in high-risk behaviors and those in high-risk groups; and implementing a national behavioral surveillance system. Addressing these challenges will improve HIV detection in the United States, which is vital to both HIV prevention and treatment.

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Patterns, correlates, and barriers to medication adherence among persons prescribed new treatments for HIV disease.

Cited by 595 publications

References 36 publications

Adherence to Antiretroviral Medication Regimens: A Test of a Psychosocial Model

Adherence to Antiretroviral Medication Regimens: A Test of a Psychosocial Model

Exploring drug users’ attitudes and decisions regarding hepatitis C (HCV) treatment in the U.S.

Effective Detection of HIV

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