Patterns and predictors of recurrence after radical resection of thymoma

Cai, Xu; Feng, Qinfu; Fan, Chengcheng; Zhai, Yirui; Chen, Yidong; Zhang, Hongxing; Xiao, Zefen; Liang, Jun; Chen, Dong-Fu; Zhou, Zongmei; Wang, Lühua; He, Jie

doi:10.1016/j.radonc.2015.03.001

Cited by 26 publications

(23 citation statements)

References 24 publications

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“…Follow up results were comparable with previous VATS and open surgery studies. Masaoka stage is widely accepted as a prognostic factor of recurrence (10,(13)(14)(15). We also demonstrated that advanced Masaoka stage was associated with poor RFS (P=0.037, HR = 12.69, 95% CI: 1.17-138.22).…”

Section: Discussionmentioning

confidence: 53%

Video-assisted thoracic surgery for thymoma: long-term follow-up results and prognostic factors—single-center experience of 150 cases

Hui

Xiao

et al. 2018

J. Thorac. Dis.

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Section: Discussionmentioning

confidence: 53%

Video-assisted thoracic surgery for thymoma: long-term follow-up results and prognostic factors—single-center experience of 150 cases

Hui

Xiao

et al. 2018

J. Thorac. Dis.

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“…Progression and recurrence after the initial thymoma is resected is observed in 6.9%-18.0% of patients and can occur even decades after the primary resection. 22,29,[39][40][41][42] In this study, thymomas located in the superior mediastinum were more likely to be associated with disease progression and tumor recurrence than those in the inferior mediastinum. The differences between the two anatomic locations of thymomas can be attributed to the following reasons.…”

Section: Discussionmentioning

confidence: 59%

Tumor location may affect the clinicopathological features and prognosis of thymomas

et al. 2019

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Background The current staging systems do not consider the tumor location of thymomas, and its clinical relevance is poorly understood. This study aimed to evaluate the impact of tumor location on the clinicopathological features and prognosis of thymomas. Methods We performed a retrospective review of patients at our institution who underwent an extended thymectomy for a thymoma from 1976 to 2015. The tumor location was classified as either the superior or inferior mediastinum based on the maximum tumor diameter. The clinicopathological characteristics of the thymoma were also evaluated. Kaplan‐Meier estimates and Cox proportional hazards models were used to analyze the survival outcomes and risk factors for recurrence. Results A total of 194 patients with thymoma were eligible for this study. Compared with the inferior mediastinum group (n = 167), the superior mediastinum group (n = 27) had a higher frequency of myasthenia gravis (MG), advanced Masaoka‐Koga staging, disease progression and recurrence (P < 0.05). The Kaplan‐Meier analysis demonstrated thymomas in the superior mediastinum had worse survival outcomes that included overall survival, progression‐free survival and disease‐free survival (P < 0.05). The multivariate analysis showed tumor location was an independent prognostic factor for all the survival outcomes (P < 0.05). Furthermore, the tumor location (P = 0.004) and Masaoka‐Koga stage (P < 0.001) were the only two independent risk factors for recurrence in the multivariate analysis. Conclusions The clinicopathological features of thymomas on MG, Masaoka‐Koga staging, disease progression, and recurrence were different between locations of superior and inferior mediastinum locations. Thymomas in the superior mediastinum tended to be associated with worse survival and increased recurrence.

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“…Recurrence may occur within the thymus left in place during the first surgical procedure or in the thoracic compartment where thymoma was located, in the pleural space opened to allow complete resection, and even at the site of the wound of the first operation or the mediastinal biopsy initially performed for tissue diagnosis [24], which suggests the risk of implantation metastasis during the operation. Other researchers find that tumor larger than 8 cm is also a risk factor of recurrence [7, 25]. Otherwise, studies on the molecular biology discover that DNA aneuploidy, IFN-αand IL-12 are also helpful in predicting the recurrence of thymoma [26–28].…”

Section: The Risk Factors Of Recurrent Thymomamentioning

confidence: 99%

The clinical features, diagnosis and management of recurrent thymoma

Luo

Zhao

Zhou

2016

J Cardiothorac Surg

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Thymoma is a disease with malignant potential, which has a recurrence rate after complete resection ranging from 5 to 50 %. Multiple studies on the risk factors, treatment or prognosis have been reported. Many of them are controversial, however. In this review, we summarized some accepted risk factors, means of diagnosis and different treatments of recurrent thymoma. The risk factors of recurrent thymoma haven’t been well-studied, and its management remains controversial. We reviewed the literatures and found some key points which should be noticed during the surgery of initial thymoma. Although reoperation should be taken into account preferentially, multimodal treatments are also available. The prognosis are also been discussed.

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Patterns and predictors of recurrence after radical resection of thymoma

Cited by 26 publications

References 24 publications

Video-assisted thoracic surgery for thymoma: long-term follow-up results and prognostic factors—single-center experience of 150 cases

Video-assisted thoracic surgery for thymoma: long-term follow-up results and prognostic factors—single-center experience of 150 cases

Tumor location may affect the clinicopathological features and prognosis of thymomas

The clinical features, diagnosis and management of recurrent thymoma

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