“…In addition, unstable medical conditions such as polytrauma or co-morbidities make some patients poor candidates for flap reconstruction. 1 Skin substitutes have been developed in recent decades to minimize donor site morbidity while optimizing a functional and aesthetic outcome. Integra (Integra LifeSciences, Inc., Plainsboro, NY, USA) was invented by Yannas and Burke 4 in 1980, and since then, various artificial dermis products such as AlloDerm (LifeCell Corporation, Branchburg, NJ, USA), 5 Dermagraft (Smith and Nephew, Largo, FL, USA), Terudermis (Olympus Terumo Biomaterials Corp., Tokyo, Japan), 6 Matriderm (MedSkin Solutions Dr. Suwelack AG, Billerbeck, Germany) 7 and Pelnac 8 have been successfully applied for the treatment of complex full-thickness wounds.…”