Patterns and grades of presentation of colon cancer in Northern Saudi Arabia

Alharbi, Saleh Hadi; Alshammari, Khalil; Alanazi, Khulaif Khalaf; Ahmed, Hussain Gadelkarim

doi:10.5114/pg.2021.104168

Cited by 5 publications

(6 citation statements)

References 21 publications

(21 reference statements)

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“…Other studies have also shown a high incidence of early-onset CRC, with a female predominance. One retrospective study was from the northern area of SA, representing all available colorectal cancers during a period of 10 years,[ 7 ] and another one was from the Saudi National Registry before 2016. [ 6 ] Our study reflects the global concern for early-onset CRC[ 15 ] with poor outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…[ 5 ] The incidence of CRC has increased recently among young people (aged <50 years). [ 6 7 ] The underlying reasons are unknown but include genetic abnormalities such as germline mutations, which is referred to as early-onset CRC (EO-CRC). [ 8 ] One in five young patients with EO-CRC carries a mutation associated with cancer predisposition.…”

Section: Introductionmentioning

confidence: 99%

“…[ 10 ] Late onset-CRC (LO-CRC), as reported in a retrospective study from 2001 to 2016 using the Saudi National Registry, and in the Northern region of the country, showed a similar trend of decreasing and increasing late- and early-onset CRC, respectively, in SA. [ 6 7 ]…”

Section: Introductionmentioning

confidence: 99%

“…The Saudi Cancer Registry ( http://www.scr.org.sa/ ) indicated a rise in CRC frequency from 2001 to 2006, this rate was twice the incidence observed from 1994 to 2001[ 11 ]; however, no data was available assessing the trend in EO-CRC. At diagnosis, young Saudis presented with advanced-stage CRC and poor outcomes[ 3 7 12 ]; however, SA has no nationwide strategy for CRC screening despite the well-established increasing incidence in Saudis under 50 years of age, which reflects 85% of the population. [ 7 13 14 ]…”

Section: Introductionmentioning

confidence: 99%

“…At diagnosis, young Saudis presented with advanced-stage CRC and poor outcomes[ 3 7 12 ]; however, SA has no nationwide strategy for CRC screening despite the well-established increasing incidence in Saudis under 50 years of age, which reflects 85% of the population. [ 7 13 14 ]…”

Section: Introductionmentioning

confidence: 99%

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A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia

Zacharakis¹,

Almasoud²,

Arahmaner³

et al. 2022

Saudi Journal of Gastroenterology

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Background: The Al-Kharj colorectal cancer (CRC) screening program was implemented for five years (2017-2022) in a central urban area of Riyadh Province, Saudi Arabia, to assess the participation and impact of the program in average-risk individuals. Methods: The high sensitivity-guaiac based-fecal occult blood test (HSgFOBT) was used as a first-line investigation to identify asymptomatic patients, aged 45–75 years, requiring CRC screening using colonoscopy. The program was run in three tertiary hospitals in the area. Results: The five-year participation rate was 73% (35,640/48,897). The average age was 53 years (range 45–75), 49% were female (17,464/35,640), all were asymptomatic, and 77% had adequate bowel preparation. The HSgFOBT (+) rate was 6.3% (n = 2245), and 76% (n = 1701) of these underwent colonoscopy. The prevalence of findings were as follows: CRC, 4.8% (81/1701); advanced adenoma, 9.5% (162/1701); adenoma, 15.9% (270/1701); non-adenomatous polyps, 7.9% (135/1701); and no polyps or tumors, 25.4% (432/1701). Among participants aged 45–50 years, early onset-CRC had female predominance, while those ≥50 years with late onset-CRC were predominantly male. CRC was more prevalent in the left colon (P < 0.005). Conclusions: Approximately one-third of the participants diagnosed with CRC had early-onset CRC. Screening participation was desirable for the defined target population. Public education is necessary along with expanded colonoscopy resources to continue further citizen participation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia

Zacharakis¹,

Almasoud²,

Arahmaner³

et al. 2022

Saudi Journal of Gastroenterology

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New Insights into Risk Factors for Postoperative Infections in Colorectal Cancer

Li,

Zhao,

Liu

2024

Preprint

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Background Postoperative incision infections are a significant concern in colorectal cancer surgery, impacting patient recovery and well-being. Identification of key risk factors for infection following colorectal cancer surgery is crucial for improving patient outcomes. Methods A meta-analytical approach was employed to analyze studies published from January 2015 to December 2022, focusing on variables such as body mass index, diabetes, albumin levels, malnutrition, and surgical duration to assess their association with postoperative infection incidence in colorectal cancer patients. Results Analysis of eleven high-quality studies revealed that elevated body mass index, diabetes, low albumin levels, malnutrition, and longer surgical durations were linked to an increased risk of postoperative incision infections. Conversely, laparoscopic procedures demonstrated potential for reducing infection risks. Conclusions Effective preoperative risk assessment and management are vital in preventing postoperative incision infections in colorectal cancer patients. These findings offer actionable insights for clinicians to optimize patient prognoses and enhance overall quality of life outcomes.

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Enhancing Outcomes Through Preoperative Risk Evaluation in Colorectal Cancer Surgery

Jia,

Zhao,

Liu

2024

Preprint

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Context: Postoperative incision infections pose a significant challenge in colorectal cancer surgery, impacting patient outcomes and healthcare costs. Purpose This meta-analysis aimed to evaluate the risk factors influencing the incidence of incision infections following colorectal cancer surgery. Methods and Results Through a systematic review of studies published between January 2015 and December 2022, key factors such as body mass index, diabetes, albumin levels, malnutrition, and surgical duration were analyzed. Findings from eleven high-quality studies indicated that high BMI, diabetes, low albumin levels, malnutrition, and prolonged surgery duration were associated with increased infection risk. Conversely, laparoscopic procedures showed promising potential for reducing infection risk. Conclusions Preoperative assessment of these risk factors is crucial for effective management and reduction of postoperative incision infections in colorectal cancer patients. Clinicians can leverage these insights to improve patient outcomes and enhance overall quality of life.

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Patterns and grades of presentation of colon cancer in Northern Saudi Arabia

Cited by 5 publications

References 21 publications

A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia

A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia

New Insights into Risk Factors for Postoperative Infections in Colorectal Cancer

Enhancing Outcomes Through Preoperative Risk Evaluation in Colorectal Cancer Surgery

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