Immunosensors are prospective tools to transform analytical methods by providing a highly specific, rapid, and inexpensive detection for use in various fields of monitoring. In this chapter, screen printing technology is used to combine different strategies with recognition molecules modified on screen-printed based electrodes for immunocomplex detection. To develop innovative immunosensors, modification of the antibody or the electrode surface by nanomaterials is often used, and these strategies are discussed. These emerging hybrid technologies have led to miniaturisation and to a greater utilisation of immunosensors available for current applications, such as point-of-care diagnostics.