Pattern visual evoked potentials in Japanese patients with multiple sclerosis without history of visual pathway involvement

Abstract

A delay of the peak latency of the pattern visual evoked cortical potentials (pVEP) is accepted as one of the paraclinical evidence for a diagnosis of multiple sclerosis (MS). The purpose of this study was to evaluate the pVEPs in Japanese patients with MS without a history of visual pathway involvement. We studied the medical records of 29 MS patients without any history of visual pathway involvement, and with visual acuity correctable to > or = 20/20. The Goldmann visual fields, pupillary light reflexes, and optic disks were normal in all. pVEPs elicited by 3 rev/s (transient) and 12 rev/s (steady-state) were recorded from the MS patients and compared with those recorded from normal subjects. The latency of the P100 component of the transient pVEPs was significantly prolonged in 9/29 (31%) MS patients. A phase lag in the steady-state pVEPs was found in 6/29 (21%) MS patients, and the mean amplitude was significantly smaller. The incidence of cases with abnormal pVEPs is lower than that reported from Europe and United State. This difference is possibly due to racial differences, and the use of different criteria for diagnosing optic neuritis.

Diagnostic Value of Conventional Visual Evoked Potentials Applied to Patients With Multiple Sclerosis

“…Some studies have suggested that the sensitivity of the technique may be as low as 25% in some circumstances, when, for example, computer monitors are used as stimuli, and can be normal in 40% to 50% of patients initially (1,32). The incidence of cases with abnormal cVEPs was also lower reported from Asia than that reported from Europe and the United States, and this difference was explained possibly due to racial differences and the use of different criteria (33).…”

Reference values of pattern reversal visual evoked potentials in Bulgarian population

“…It is confirmed by the literature review. 1,2,11–13 The most variable components were P50 and P200. The reason for the variability of component P50 was that the active electrode was placed at Oz, far after the retinal ganglion cells layer.…”

Subklinik Multipl Skleroz Hastalarının Desen Görsel Uyarılmış Potansiyeller ve Görme Alanı Testi ile Değerlendirilmesi

“…7-9 Atsushi Mizota ve ark. 10 görmesi tam ve muayenesi normal olan 29 MS hastasını dahil ettikleri çalışmada PVEP latansında uzama göstermişler ve istatiksel analizde kontrol grubuna göre anlamlı fark bulmuşlardı. Fakat amplitüdde gruplar arasında anlamlı bir fark gösterilememiştir.…”