Pattern Visual Evoked Potential in Non Diabetic offspring‘s of Type II Diabetes

Abstract

Metabolic abnormalities in diabetes mellitus involves ganglionic and preganglionic elements in the entire retina and macular region causing visual disturbances. Subclinical central nervous system (CNS) dysfunctions have been reliably detected by visual evoked potentials in patients with uncomplicated diabetes and normal brain Computed tomography (CT) scan. The offspring of diabetic parents have a higher risk of diabetes and a possibility of diabetic retinopathy. The study aims at evaluating visual evoked potential in asymptomatic, non-diabetic offspring of diabetic parents. A total of 150 individuals in each group (case and controls) were enrolled after Written and informed consent. Institutional ethical Committee approval was obtained. Visual evoked potential (VEP) recordings were done using the standard procedure given in Recommended Standards for VEP, Guidelines 9B. The statistical analysis revealed significant difference in controls and offspring of diabetic parents in terms of P100 latency in both left and right eye (P<0.05). The offspring of diabetic parents may be screened with VEP, as, prolongation of P100 latency a direct sign of retinal damage and demyelination could add the risk to the fact that they may be in a pre-diabetic stage without clinical manifestation, but there may be subclinical optic pathway involvement which mandates active intervention to reduce the co-morbidly associated with diabetes.

Visual Evoked Potentials for the Detection of Diabetic Retinal Neuropathy

“…Investigating the effects of DM in neonates and children using VEP is also important [ 74 , 78 , 83 , 84 , 92 , 118 , 119 , 120 , 121 ].…”

“…The offspring of non-IDDM (NIDDM) parents showed a significant delay in VEP P100 latency compared with the controls. When compared within groups with NIDDM parents, offspring with both parents with diabetes showed significantly longer P100 latencies than those with one parent with diabetes [ 120 ].…”