Pattern reactivation co-varies with activity in the core recollection network during source memory

Leiker, Emily; Johnson, Jeffrey D.

doi:10.1016/j.neuropsychologia.2015.05.021

Cited by 28 publications

(37 citation statements)

References 73 publications

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“…Theoretical accounts posit that reinstated representations in CA 3 and CA 1 act as predictions about present events derived from past knowledge. Limited support for this proposal is found in existing neuroimaging work that suggests the magnitude of hippocampal activation during retrieval is correlated with the speed of memory decisions (Gordon et al, 2014) and confidence judgments (Leiker and Johnson, 2015; Thakral et al, 2015). In the current study, we provided a direct test of the role of the hippocampus in memory retrieval by linking trial-by-trial item reinstatement signatures to the accumulation of evidence in a computational model of memory-based decisions.…”

Section: Discussionmentioning

confidence: 96%

“…The hippocampus has also been implicated in several fMRI studies examining cortical reinstatement. Hippocampal activation during both encoding and retrieval scales with task (Leiker and Johnson, 2015), category (Gordon et al, 2014; Horner et al, 2015) and item (Ritchey et al, 2012; Wing et al, 2015) reinstatement signatures in neocortex. In particular, Ritchey et al (2012) found a relationship between hippocampal univariate activation and the degree of encoding-retrieval pattern similarity in cortical regions, consistent with the notion that hippocampus mediates memory reinstatement in cortex.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the link between reinstatement and behavior observed in these studies is based on the indirect comparison of cortical reinstatement signatures during successful versus unsuccessful memory choices, thus limiting the sensitivity of evaluating the direct influence of reinstatement on decision making on a trial-by-trial basis. Recent neuroimaging evidence shows that the magnitude of hippocampal activation is linked to memory confidence judgments (Leiker and Johnson, 2015; Thakral et al, 2015) and the speed of memory decisions (Gordon et al, 2014), with greater retrieval-related activation for higher confidence and faster responses. Electrophysiological work in humans has further identified single cells within the hippocampus that exhibit firing patterns consistent with a graded representation of memory strength and confidence during recognition decisions (Rutishauser et al, 2015).…”

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confidence: 99%

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Decisions about the past are guided by reinstatement of specific memories in the hippocampus and perirhinal cortex

Mack

Preston

2016

NeuroImage

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When faced with a new challenge, we often reflect on related past experiences to guide our behavior. The ability to retrieve memories that overlap with current experience, a process known as pattern completion, is theorized as a critical function of the hippocampus. Although this view has influenced research for decades, there is little empirical support for hippocampal pattern completion to individual memory elements and its influence on behavior. We used pattern analysis of brain activity measured with functional magnetic resonance imaging to demonstrate that specific elements of past experiences are reinstated in the hippocampus, as well as perirhinal cortex (PRC), when making decisions about those experiences. Linking neural measures of specific memory reinstatement in the hippocampus and PRC to behavior with computational modeling revealed that reinstatement predicts the speed of memory-based decisions. Moreover, hippocampal activation during retrieval was selectively coupled to regions of occipito-temporal cortex that showed content-specific item reinstatement. These results provide evidence for hippocampal pattern completion and its role in the mechanisms of decision making.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Decisions about the past are guided by reinstatement of specific memories in the hippocampus and perirhinal cortex

Mack

Preston

2016

NeuroImage

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“…As such, they are a type of associative memory task and place greater demands on recollection processes compared to item recognition tasks (Yonelinas, 1999). Neuroimaging studies of healthy young adults indicate that recollection of spatial contextual details relies on the activation of a distributed network of brain regions that include the medial temporal lobe (MTL), prefrontal cortex (PFC) and inferior parietal cortex (Rajah et al, 2011, Spaniol and Grady, 2010, Slotnick et al, 2003, Leiker and Johnson, 2015). Recently, we have examined the functional brain differences between middle-aged adults (MA) and young adults during the encoding and retrieval of contextual details (Kwon et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Family history and APOE4 risk for Alzheimer's disease impact the neural correlates of episodic memory by early midlife

Rajah

Wallace

Ankudowich

et al. 2017

NeuroImage: Clinical

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Episodic memory impairment is a consistent, pronounced deficit in pre-clinical stages of late-onset Alzheimer's disease (AD). Individuals with risk factors for AD exhibit altered brain function several decades prior to the onset of AD-related symptoms. In the current event-related fMRI study of spatial context memory we tested the hypothesis that middle-aged adults (MA; 40–58 yrs) with a family history of late onset AD (MA+ FH), or a combined + FH and apolipoprotein E ε4 allele risk factors for AD (MA+ FH + APOE4), will exhibit differences in encoding and retrieval-related brain activity, compared to − FH − APOE4 MA controls. We also hypothesized that the two at-risk MA groups will exhibit distinct patterns of correlation between brain activity and memory performance, compared to controls. To test these hypotheses we conducted multivariate task, and behavior, partial least squares analysis of fMRI data obtained during successful context encoding and retrieval. Our results indicate that even though there were no significant group differences in context memory performance, there were significant differences in brain activity and brain-behavior correlations involving the hippocampus, inferior parietal cortex, cingulate, and precuneus cortex in MA with AD risk factors, compared to controls. In addition, we observed that brain activity and brain-behavior correlations in anterior-medial PFC and in ventral visual cortex differentiated the two MA risk groups from each other, and from MAcontrols. Our results indicate that functional differences in episodic memory-related regions are present by early midlife in adults with + FH and + APOE-4 risk factors for late onset AD, compared to middle-aged controls.

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“…The activation of the left middle frontal gyrus corroborates Kensinger and Schacter's (2006) observation. With regard to the parietal lobe, it has been proposed as being involved in the retrieval of contextual information (Kensinger & Schacter, 2006;King & Miller, 2014;Kurkela & Dennis, 2016;Leiker & Johnson, 2015;Mitchell & Johnson, 2009). …”

mentioning

confidence: 99%

Remembering verbally-presented items as pictures: Brain activity underlying visual mental images in schizophrenia patients with visual hallucinations

Stephan‐Otto

Siddi

Senior

et al. 2017

Cortex

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Background: Previous research suggests that visual hallucinations in schizophrenia consist of mental images mistaken for percepts due to failure of the reality-monitoring processes. However, the neural substrates that underpin such dysfunction are currently unknown. We conducted a brain imaging study to investigate the role of visual mental imagery in visual hallucinations. Method: Twenty-three patients with schizophrenia and 26 healthy participants were administered a reality-monitoring task whilst undergoing an fMRI protocol. At the encoding phase, a mixture of pictures of common items and labels designating common items were presented. On the memory test,

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Pattern reactivation co-varies with activity in the core recollection network during source memory

Cited by 28 publications

References 73 publications

Decisions about the past are guided by reinstatement of specific memories in the hippocampus and perirhinal cortex

Decisions about the past are guided by reinstatement of specific memories in the hippocampus and perirhinal cortex

Family history and APOE4 risk for Alzheimer's disease impact the neural correlates of episodic memory by early midlife

Remembering verbally-presented items as pictures: Brain activity underlying visual mental images in schizophrenia patients with visual hallucinations

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