Abstract:Background: DNA methylation (DNAm) may play an important role in birth outcomes.
Material and Methods: Genome wide DNAm was analysed in peripheral blood DNA of women at multiple time points during gestation. A novel empirical method was used to identify CpG sites with high temporal variance in methylation associating with preterm birth.
Results: High variability at 1296 CpG sites from the promoter regions of 1197 genes significantly associated with PTB. These genes belonged to pathways involved in signalling b… Show more
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