Pattern of salivary gland tumors in Manipur, India: A 10 year study

Abstract

Background:Salivary gland lesions, especially the neoplastic lesions constitute a highly heterogeneous histopathologic group. Several studies have reported a significant difference in the global distribution of salivary gland tumors, but no formal study has been carried out in this part of the globe.Objectives:To document the pattern of various salivary gland tumors in Manipur, a state in North Eastern India.Materials and Methods:This is a 10 years (2002-2011) retrospective study of all salivary gland specimens received at our referral teaching hospital in Manipur, India. All the histopathology slides of salivary gland specimens during the study period were reviewed and clinical details were obtained from the archives. Restaining of slides and fresh sections of tissue blocks were performed whenever required. Data thus collected were analyzed.Results:A total of 104 cases of salivary gland lesions were studied during the study period. Age ranged from 5 years to 78 years with an overall slight female preponderance (M:F = 1:1.08). Parotid (56.65%) was the commonest gland involved followed by submandibular gland (31.73%).Neoplastic lesions comprised of 78 (75%) cases and non-neoplastic lesions constituted 25% (26 cases). Among the neoplastic lesions, benign lesions (53.85%) predominated over malignant lesions (21.15%). Pleomorphic adenoma was the commonest benign neoplastic lesion and mucoepidermoid carcinoma was the commonest malignant tumor. Chronic sialadenitis was the predominant lesion in the non-neoplastic group.Conclusion:The principal site for salivary gland tumors was the parotid gland and pleomorphic adenoma outnumbered all the other tumors. Females are more affected in the malignant group.

Histopathological Spectrum of Salivary Gland Tumors in Tripura, India: A Seven Year Study

“…10,14,15 Warthin tumor (13.51%) was the second commonest benign tumor similar to the observation of Chung et al 16 Out of 25 cases of pleomorphic adenomas 18 involved parotid, 4 involved submandibular gland and 3 cases involved minor salivary glands. All the five cases of Warthin tumor affected only the parotid gland, which is similar to the finding reported by Laishram et al 4 In the present series adenoid cystic carcinoma was the most common salivary gland tumor comprising 44.44% cases (4 cases out of 9 malignancies)[ Fig.2]. Ahmad et al and Rewsuwan et al also reported similar observation in their studies.…”

“…5 Studies by Laishram et al in Manipur and Ahmad et al in Kashmir were also comparable to our study. 4,6 Our study showed high incidence of both benign and malignant tumors in 5 th decade and after 60 years. However Satko et al and Ahmad et al reported the highest incidence of benign tumors in the 3 rd to 4 th decade and malignant tumors in 4 th to 5 th decade of life.…”

“…11 Similarly, Laishram et al found male predominance in benign lesions in Manipur and Ahmad et al observed that males are more affected by both benign and malignant neoplasms of salivary glands in Kashmir. 4,6 This may be due to the regional differences or the size of the samples used in each study.…”

“…Pleomorphic adenoma was the Fig.1]. 4 However, pleomorphic adenoma had been listed universally as the most common tumor in all the studies with a range of 40-72%. 10,14,15 Warthin tumor (13.51%) was the second commonest benign tumor similar to the observation of Chung et al 16 Out of 25 cases of pleomorphic adenomas 18 involved parotid, 4 involved submandibular gland and 3 cases involved minor salivary glands.…”

“…3 The incidence of salivary gland tumors is claimed to be influenced by geographical and racial factors, which makes it difficult to establish global estimates. 4,5,6,7 In view of the fact that these tumors are treated on the basis of their histological and local findings, correct histological diagnosis is obligatory. 3 Local records are a useful strategy for the analysis of the distribution and particular features of salivary gland tumors in a specific population.…”