The widespread accessibility of antimicrobials transformed the path of olden times. Many infections beforehand not curable found treatment, for example, tuberculosis. Scientist, common people thought once that humankind has able conquered microbial diseases. Nonetheless, irrational and unnecessary use antimicrobials create resistant microbes throughout the universe. Moreover, the development new antimicrobials have slowed down, particularly for those diseases of developing countries who have very poor financial ability to pay the research overhead of the inventor. Thereafter, currently available antimicrobials antimicrobials are loosing their efficacy and spectrum everyday against resistant microbes. Subsequently, once those diseases were treatable with no antimicrobials or very low profile agents now need the higher form of antimicrobials even multiple agents. As such health care cost is increasing every day which is beyond the economic ability of common people of anywhere of the world. All these 10 developing countries very frequently were observed that overuse and irrational use of antimicrobials. Researchers of these developing countries opined that answer remains in continuing medical education for all health-related stakeholders and appropriate policy to stop irrational prescribing, and promote prudent and rational prescribing and use of medicine, including antimicrobials.