Pattern of organ remodeling in chronic non-communicable diseases is due to endogenous regulations and falls under the category of Kauffman’s self-organization: A case of arterial neointimal pathology

Atherosclerosis originating from childhood: Specific features

“…DIT is considered a normal occurrence in human arteries, exhibiting a well-organized structure comprising smooth muscle cells (SMCs), elastin, and proteoglycans. DIT is often associated with atherosclerosis and is mainly found in atherosclerosis-prone arteries [ 33 ] .…”

“…The arterial intima, which is the inner layer of arteries, thickens with age and consists of fibrocellular tissue [31] . Two types of intimal thickening have been identified: eccentric intimal thickening and diffuse intimal thickening (DIT) [32] . DIT is considered a normal occurrence in human arteries, exhibiting a well-organized structure comprising smooth muscle cells (SMCs), elastin, and proteoglycans.…”