Pattern of mRNA expression of β-defensins in basal cell carcinoma

Gambichler, Thilo; Skrygan, Marina; Huyn, Julia; Bechara, F. G.; Sand, Michael; Altmeyer, Peter; Kreuter, Alexander

doi:10.1186/1471-2407-6-163

Cited by 52 publications

(59 citation statements)

References 15 publications

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“…Several studies reported increased expression of b-defensins in different tumor tissues (11)(12)(13). Kawsar et al (14) demonstrated expression of hBD2 in malignant tumor lesions, but not in healthy stroma, suggesting that hBD2 may play a role in tumor angiogenesis.…”

mentioning

confidence: 99%

Mouse β-Defensin 14 (Defb14) Promotes Tumor Growth by Inducing Angiogenesis in a CCR6-Dependent Manner

Röhrl

Huber

Koehl

et al. 2012

The Journal of Immunology

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β-defensins are known for their antimicrobial activity and belong to the molecular barrier of the innate immune system against invading pathogens. In addition, it has been shown that some members of the β-defensin superfamily have the capacity to promote local innate inflammatory and systemic adaptive immune responses, mediated in part by the interaction with CCR6. We found that mouse β-defensin 14 (mBD14, Defb14), a newly identified member of the mouse β-defensin superfamily, is expressed in mouse fibrosarcoma tumor tissue. Tumor cells overexpressing mBD14 demonstrated enhanced solid tumor growth in syngeneic C57BL/6 mice concomitant with increased vascularization of these tumors. Furthermore, mBD14-overexpressing tumors demonstrated increased expression of proangiogenic MIP-2 (CXCL2) ex vivo. In contrast, vascular endothelial growth factor expression was not affected. Cellular analysis of tumor-infiltrating leukocytes revealed a significant increase of CCR6+ B220+ lymphocytes in solid tumors derived from mBD14-overexpressing tumor cells. Enhanced tumor growth of mBD14-overexpressing fibrosarcomas was abolished in CCR6-deficient mice, which was paralleled by decreased infiltration of CCR6+ B220+ lymphocytes, indicating the requirement of CCR6 expression on host cells. Previously, the interaction of activated, LTαβ+, lymphocytes with lymphotoxin β-receptor–expressing fibrosarcoma tumor cells has been identified as a new CXCL2-dependent proangiogenic pathway. Coexpression of a soluble lymphotoxin β-receptor:Ig fusion protein, an inhibitor of CXCL2-dependent angiogenesis, in mBD14-overexpressing fibrosarcoma tumor cells abolished enhanced solid tumor growth. Thus, we conclude that mBD14 expression by tumor-infiltrating host cells results in the chemoattraction of CCR6+ B220+ lymphocytes, which in turn initiates a proangiogenic pathway leading to enhanced angiogenesis and organized tumor tissue development.

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mentioning

confidence: 99%

Mouse β-Defensin 14 (Defb14) Promotes Tumor Growth by Inducing Angiogenesis in a CCR6-Dependent Manner

Röhrl

Huber

Koehl

et al. 2012

The Journal of Immunology

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“…Podnoszona jest ich rola nie tylko w progresji, lecz także w supresji nowotworowej, zwłaszcza w przypadku takich AMPs, jak defensyny, LL-37 i grupa białek S100 z psoriazyną na czele. Wykazano związek ludzkiej β-defensyny 1 (hBD-1) z rakiem jasnokomórko-wym nerki, rakiem prostaty i rakiem jamy ustnej [25,26]; psoriazyny z rakiem pęcherza moczowego i rakiem piersi [27]; hBD-1-3 z BCC i ziarniniakiem grzybiastym [28,29]. Ekspresja hBD-2 jest znacząco zmniejszona w zmianach śródpłaskonabłonkowych wysokiego stopnia (ang.…”

Section: Peptydy Przeciwdrobnoustrojowe W Nowotworach Skóryunclassified

“…Gambichler i wsp. [28] stwierdzili istotną zmianę ekspresji hBD-1 i hBD-2 u pacjentów z BCC w porównaniu ze zdrową skórą osób z grupy kontrolnej. Ekspresja genów defensyny hBD-2 w BCC była podobna do ekspresji w dermatozach o podłożu zapalnym, takich jak atopowe zapalenie skóry i łuszczyca.…”

Section: Peptydy Przeciwdrobnoustrojowe W Nowotworach Skóryunclassified

“…Nie stwierdzono różnic w ekspresji β-defensyn w zależności od podtypu BCC. Nie wykazano także istotnej różnicy w konstytutywnej ekspresji genów β-defensyn, ponieważ ekspresja mRNA β-defensyn w skórze nieobjętej procesem nowotworowym u pacjentów ze stwierdzonym BCC i w zdrowej skórze grupy kontrolnej była zbliżona [28]. Warto zaznaczyć, że defensyna hBD-1 jest konstytutywnie produkowana w skórze, a jej poziom nie zwiększa się pod wpływem stanu zapalnego, w przeciwieństwie do hBD-2 czy hBD-3 [35].…”

Section: Peptydy Przeciwdrobnoustrojowe W Nowotworach Skóryunclassified

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The role of antimicrobial peptides in skin tumorigenesis

Marcinkiewicz¹,

Majewski²

2016

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“…Because of the structural and chemical nature diversity of AMPs, also the probability of microbes to resist AMPs is much lower than conventional antibiotics, make them a good candidate for a novel drug with anti bacterial, anti fungal and anti viral properties [48,49]also Anti parasitic activity [50] and AMPs may used in treatment of cancer [51,52,53] and HIV infections [54].…”

Section: Antimicrobial Peptides Therapeutic Applications and Drug Devmentioning

confidence: 99%

Scorpion venom as antimicrobial peptides (AMPs): A review article

Tarazi

2015

int. arab. j antimicrob. agents

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The high level of reported multidrug resistant pathogens with the failure of most conventional antibiotic to kill many of them arise the global concern in the last decade to find alternatives urgently. Many researches have been conducted on scorpion venom biological characteristics, and its different antimicrobial peptides had been reported in literature since the last decade. Here short overview of all scorpion AMPs with antibacterial activity, their structural determinants, classification types and their mode of action, in addition to their resistance mechanism and finally their therapeutics potential.

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Pattern of mRNA expression of β-defensins in basal cell carcinoma

Cited by 52 publications

References 15 publications

Mouse β-Defensin 14 (Defb14) Promotes Tumor Growth by Inducing Angiogenesis in a CCR6-Dependent Manner

Mouse β-Defensin 14 (Defb14) Promotes Tumor Growth by Inducing Angiogenesis in a CCR6-Dependent Manner

The role of antimicrobial peptides in skin tumorigenesis

Scorpion venom as antimicrobial peptides (AMPs): A review article

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