Pattern of Mineral Uptake in Developing Bovine Incisors

Robinson, C.; Weatherell, J.A.; El-Attar, I.; Deutsch, D.

doi:10.1159/000260481

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…This process is similar to that observed in rats (Hiller at al. 1975) and bovid (Robinson et al 1980). This process differs in some creatures (such as pigs), in which enamel may not mature until it has erupted (Kirkham et al 1988).…”

Section: An Introduction To Dentogenesismentioning

confidence: 99%

Spatially Resolved Strontium Isotope Micro-Analysis of Lower and Middle Palaeolithic Fauna from Archaeological Sites in Israel and Southern France

Moffat¹

2020

Preprint

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The use of strontium isotope analysis to provenance biominerals such as bone and teeth has become a regularly applied component of archaeological research. This method works by comparing the isotopic composition of these materials with regional bioavailable soil values, allowing an estimation of the distance and vector of an individual’s mobility. New advances in analytical equipment has facilitated the spatially resolved micro-analysis of strontium isotope composition using laser ablation sampling, allowing intra-sample heterogeneity to be quantified. This provides the opportunity to determine not only the overall provenance of a material, but also the degree of mobility during biomineral formation.This research applies laser ablation multi-collector inductively coupled plasma mass spectroscopy (LA-MC-ICPMS) to 90 teeth of Lower and Middle Palaeolithic faunal prey from Lower and Middle Palaeolithic archaeological sites within Israel and France. These sites span a crucial period in human evolution, characterised by the radiation of multiple hominin species and by dynamic oscillations of climate with attendant changes in fauna and flora. The strontium isotope values from LA-MC-ICPMS analysis in this thesis show a high level of intra-sample variability, which would not have been captured by a traditional analytical methodology. This suggests that, despite some problems in obtaining accurate results due to offsets between solution and laser values, strontium isotope studies that do not utilise spatially resolved micro-analysis are unable to accurately determine mobility.The results of this research demonstrate that fauna from the archaeological sites of interest—including Amud, Qafzeh, Tabun, Skhull, Holon, Bois Roche, Le Moustier, La Chapelle-aux-Saints, Les Fieux, Pech de l’Azé II and Rescoundudou—appear to have patterns of mobility that are controled by variables such as species, marine isotope stages (MIS) and regional physiography. Specifically, Persian fallow deer, bison, mountain goat/chamois and fox are frequently mobile between different geological environments during amelogenesis while wild boar and rhinoceros are sessile. The calculated range of distance for minimum possible mobility for each sample is large, ranging from 0 km to 350 km. The median values for minimum possible mobility for each species suggest that wild boar, bison and fox are mobile over the greatest distance while Bos, rhinoceros, Persian fallow deer and unidentified deer are mobile over the least. Furthermore, fauna in MIS 4 and 3 are significantly more mobile than in MIS 6 and 5. Fauna from France are more mobile than those from Israel, which is attributed to the location of the archaeological sites adjacent to significant river systems that could serve as conduits of mobility, even during inhospitable climate periods. Overall, these insights show that strontium isotope analysis can be usefully applied to quantifying mobility on a broad temporal and geographic scale, rather than simply being used, as is typical, for locating the source of material within a specific archaeological site.

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Section: An Introduction To Dentogenesismentioning

confidence: 99%

Spatially Resolved Strontium Isotope Micro-Analysis of Lower and Middle Palaeolithic Fauna from Archaeological Sites in Israel and Southern France

Moffat¹

2020

Preprint

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“…Based on companion histological studies, they concluded that stage 1 strips were from the secretory stage of amelogenesis whereas stage 3 and 4, and possibly stage 2, strips were from the maturation stage of amelogenesis (Robinson et al, 1981b;Robinson and Kirkham, 1984a). While subsequently demonstrated to be a very powerful approach for studying enamel development in rat incisors (Robinson et al, 1977(Robinson et al, , 1979(Robinson et al, , 1982(Robinson et al, , 1983Kirkham, 1984a,b, 1985) and teeth of limited eruption (Glimcher et al, 1977;Robinson et al, 1978Robinson et al, , 1980Robinson et al, , 1981aRobinson et al, , 1988aDeutsch and Pe'er, 1982;Fincham et al, 1982;Deutsch et al, 1984;Kirkham, 1984a,b, 1985;Overall and Limeback, 1988), uncertainty remains about the exact location in a series of strips for the boundary between the secretory and maturation stages of amelogenesis (see Leblond and Warshawsky, 1979;Robinson et al, 1981b;Robinson and Kirkham, 1984a). Similarly, despite its use as a major reference point for enamel development, the location of the opaque boundary (Robinson et al, 1974(Robinson et al, , 1977(Robinson et al, , 1979(Robinson et al, , 1982(Robinson et al, , 1983Kirkham, 1984a, 1985) within the maturation stage of amelogenesis is not defined precisely at present.…”

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confidence: 99%

A method for sampling the stages of amelogenesis on mandibular rat incisors using the molars as a reference for dissection

1989

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A method for locating specific stages of amelogenesis on continuously erupting incisors was devised for rats weighing 101 +/- 5 g (n = 32). The technique is based on reflecting reference lines from the mandibular molars as perpendiculars to the labial surface of mandibular incisors. From these reference lines additional measurements are then made along the midline of the labial surface of the incisor in an apical or incisal direction to find the site desired for sampling. Histological studies on 24 decalcified incisors split into segments by using such reference lines and reconstructed by morphometry indicated that a reference line reflected from the contact point between the 2nd and 3rd molars crossed the enamel organ and adjacent enamel at 3,181 +/- 329 microns incisal to the start of the secretory zone of amelogenesis. A reference line from the 2nd and 1st molars crossed the enamel organ and enamel at 1,238 +/- 424 microns incisal to the start of the maturation zone of amelogenesis, while a reference line from the mesial side of the 1st molar crossed the enamel organ and enamel almost exactly where the enamel becomes completely soluble following prolonged decalcification in EDTA. Although reference lines were reproducible within a group of male rats having similar body weights, the linear distance between the apical end of the incisor and the point at which they crossed the tooth increased at a rate of 1 mm per 159 g for rats between 50 and 300 g body weight. This suggests that molars do not maintain a fixed relationship to incisors over time, and extreme care must be taken to standardize an experiment to a specific body weight when using this method.

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“…Concomitantly, blood vessels become intimately associated with, but do not invade, the enamel organ and anastomose among the papillae (Skobe, 1980). Changes within the maturation zone include rapid loss of amelogenins and a large increase in mineral content of the forming enamel (Fincham and Belcourt, 1985;Robinson et al, 1980). Since papillary cells do not form by mitotic division of progenitor cells (Kallenbach, 1972), the cytostructure and function of the existing dental follicle must be altered to form papillary cells.…”

Section: Biosynthesis Of Macromolecules By Follicle Explant Culturesmentioning

confidence: 99%

Current Concepts of the Biology of Tooth Eruption

Gorski

Marks

1992

Critical Reviews in Oral Biology & Medicine

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Tooth eruption is defined as the movement of a tooth from its site of development within the jaws to its position of function within the oral cavity. We present a critical review of evidence for the mechanisms and regulation of the intraosseous and supraosseous phases of eruption, with an emphasis upon the canine premolar model studied by the authors. Analyses at different stages of premolar eruption indicate that selective fragmentation of dental follicle protein DF-95 correlates with the presence of elevated levels of follicular collagenase and stromelysin, and with the onset of premolar movement. A dramatic decrease in these metalloproteinases followed initiation of movement. A biochemical and cell biological model for regulation of tooth eruption is proposed based upon these new and existing data.KEY WORDS: dental follicle, metalloproteinase, osteoclast, proteolysis, extracellular matrix. OVERVIEW OF TOOTH ERUPTIONTooth eruption is defined as the movement of a tooth from its site of development within the jaws to its position of function within the oral cavity (Massler and Schour, 1941). In spite of intensive research over the last 3 decades, the specific mechanisms responsible for tooth eruption, not to mention their regulation, are not understood. This is partly due to the complex nature of the eruptive process itself and partly to the inherent lag of our understanding of the biology of mineralized tissues compared to that of other tissues. Our emphasis here will be a critical analysis of experimental studies of tooth eruption, their synthesis into working (and testable) hypotheses about tooth eruption, and extrapolation of these data to basic and clinical research. Recent reviews of tooth eruption have been published (Jacobson, 1983; Stedle and Proffit, 1985;Thesleff, 1987;Marks, 1987;Cahill et al., 1988; and the interested reader is referred to them for other emphases. What we hope to show in this review is an emergent appreciation of the roles of different types of cells in distinct phases of tooth eruption and the influences of preceding cellular events on succeeding ones. These processes in turn have applications in both the basic and clinical sciences. To the basic scientist, tooth eruption is a model system in which to explore the developmental biology of mineralized and soft tissues, including the role of proteases, growth factors, and cell adhesion in development. To the clinician, the applied biology of tooth eruption includes appreciation of the role of the dental follicle in tooth bud transplantation and eventual use of the biochemistry of tooth eruption to control retention

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Pattern of Mineral Uptake in Developing Bovine Incisors

Cited by 7 publications

References 7 publications

Spatially Resolved Strontium Isotope Micro-Analysis of Lower and Middle Palaeolithic Fauna from Archaeological Sites in Israel and Southern France

Spatially Resolved Strontium Isotope Micro-Analysis of Lower and Middle Palaeolithic Fauna from Archaeological Sites in Israel and Southern France

A method for sampling the stages of amelogenesis on mandibular rat incisors using the molars as a reference for dissection

Current Concepts of the Biology of Tooth Eruption

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