“…There is no uniform therapy standard with regard to the extent of the radiation volumes [5] , [6] , [7] , [8] , [9] , [10] in the case of unilateral cervical manifestations. These unilateral cervical manifestations are the majority of cases with 75–90 % of all SCC-CUPs [5] , [11] . Historically, bilateral neck irradiation for SCC-CUP has been considered standard of care [12] .…”