Pattern of Malformation in Offspring of Chronic Alcoholic Mothers

Jones, KennethL.; Smith, Dale E.; Ulleland, ChristyN.; Streissguth, Ann P.

doi:10.1016/s0140-6736(73)91291-9

Cited by 1,889 publications

(307 citation statements)

References 7 publications

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“…In human research, the link between heavy drinking occasions during pregnancy and the risk of FAS is well established 65, 66, 67, 68, 69, 70. For low amounts of alcohol (8–28 g per occasion), several studies have found that there is no increased risk of behavioural and/or developmental deficits in children 69, 71, 72, 73.…”

Section: Resultsmentioning

confidence: 99%

The relationship between different dimensions of alcohol use and the burden of disease—an update

et al. 2017

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Background and aimsAlcohol use is a major contributor to injuries, mortality and the burden of disease. This review updates knowledge on risk relations between dimensions of alcohol use and health outcomes to be used in global and national Comparative Risk Assessments (CRAs).MethodsSystematic review of reviews and meta‐analyses on alcohol consumption and health outcomes attributable to alcohol use.For dimensions of exposure: volume of alcohol use, blood alcohol concentration and patterns of drinking, in particular heavy drinking occasions were studied. For liver cirrhosis, quality of alcohol was additionally considered. For all outcomes (mortality and/or morbidity): cause of death and disease/injury categories based on International Classification of Diseases (ICD) codes used in global CRAs; harm to others.ResultsIn total, 255 reviews and meta‐analyses were identified. Alcohol use was found to be linked causally to many disease and injury categories, with more than 40 ICD‐10 three‐digit categories being fully attributable to alcohol. Most partially attributable disease categories showed monotonic relationships with volume of alcohol use: the more alcohol consumed, the higher the risk of disease or death. Exceptions were ischaemic diseases and diabetes, with curvilinear relationships, and with beneficial effects of light to moderate drinking in people without heavy irregular drinking occasions. Biological pathways suggest an impact of heavy drinking occasions on additional diseases; however, the lack of medical epidemiological studies measuring this dimension of alcohol use precluded an in‐depth analysis. For injuries, except suicide, blood alcohol concentration was the most important dimension of alcohol use. Alcohol use caused marked harm to others, which has not yet been researched sufficiently.ConclusionsResearch since 2010 confirms the importance of alcohol use as a risk factor for disease and injuries; for some health outcomes, more than one dimension of use needs to be considered. Epidemiological studies should include measurement of heavy drinking occasions in line with biological knowledge.

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Section: Resultsmentioning

confidence: 99%

The relationship between different dimensions of alcohol use and the burden of disease—an update

et al. 2017

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“…FASD is an under-diagnosed umbrella term for a range of disorders caused by the teratogenic effects of alcohol on the developing fetus (Table 1). FAS, the most severe form of these disorders, was first described by Lemoine and colleagues in France in 1968, with Jones et al [8] coining the term in 1973. Replicating reports of the condition soon followed from Canada, European countries and SA.…”

Section: Fas As a Burden Of Disease Attributed To Alcohol Use In Soutmentioning

confidence: 99%

Fetal alcohol spectrum disorders: Prevalence rates in South Africa

2016

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Background. Fetal alcohol spectrum disorder (FASD) is an under-diagnosed condition in South Africa (SA). Fetal alcohol syndrome and FASD community prevalence studies were undertaken in 17 towns in three of the nine provinces in SA. Objective. The objective for all the studies was to determine the FASD prevalence rates by assessing the grade 1 learners in all the studies, using international FASD diagnostic criteria. Methods. The same methodology was used for all the studies in Gauteng, Western and Northern Cape provinces. Consenting grade 1 learners received anthropometric screening, clinical examinations and neurodevelopmental assessments. Structured interviews were used to assess maternal alcohol consumption during pregnancy. Results. Reported prevalence rates ranged from 29 to 290 per 1 000 live births. Conclusion. FASD rates from studies conducted in SA are among the highest worldwide. FASD affects all communities in SA and is therefore a major public health concern in SA. Multidisciplinary and intersectoral interventions are urgently required to raise awareness about the dangers of prenatal alcohol exposure and the devastating effect of FASD on the lives of children, families and communities.

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“…His extensive findings were published, establishing that there was a significantly higher incidence of stillbirth babies, miscarriage, and a statistically significant increase in the incidence of epilepsy amongst their surviving offspring, compared to pregnant women who did not drink whilst pregnant. [5][6][7] In 1957, Rouquette on the same page submitted a doctoral dissertation in Medicine at the University of Paris entitled, "Influence of Parental Alcoholic Toxiomania on the Physical and Psychic Development of Young Children". A decade later, the research of Dr. P. Lemoine, and other team researchers, reinforced and extended the conclusions of Rouquette by demonstrating that alcohol pregnancy clearly increases the rates of still birth, along with two new categories of adverse consequences, namely, growth deficiency, and malformations among the children of alcoholic women.…”

Section: Historical Background Of Medical Concern With Alcohol Pregnamentioning

confidence: 99%

Pregnant Women Never Drink Alone (Part 1)

Laura¹

2017

Women Health Open J

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Pattern of Malformation in Offspring of Chronic Alcoholic Mothers

Cited by 1,889 publications

References 7 publications

The relationship between different dimensions of alcohol use and the burden of disease—an update

The relationship between different dimensions of alcohol use and the burden of disease—an update

Fetal alcohol spectrum disorders: Prevalence rates in South Africa

Pregnant Women Never Drink Alone (Part 1)

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