Pattern of HPV infection in basal cell carcinoma and in perilesional skin biopsies from immunocompetent patients

Zakrzewska, K.; Regalbuto, Elisa; Pierucci, Federica; Arvia, Rosaria; Mazzoli, Sandra; Gori, Alessia; Giorgi, Vincenzo De

doi:10.1186/1743-422x-9-309

Cited by 35 publications

(50 citation statements)

References 33 publications

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“…In one study [14], α-HPV in BCC was positive in 35% of the cases that the high-risk HPV genotypes observed in these patients were HPV 16, 35, 58 and 59. The findings of a research [5] demonstrated that β1-HPVs were the most common HPV types detected in the skin of BCC patients. Moreover, these types and mixed infections are significantly more frequent in tumor samples than in healthy perilesional skin and the results suggested that the types as well as co-infection with more than one viral type could be important in BCC.…”

Section: Discussionmentioning

confidence: 99%

“…Out of 45 studies reported during 1991 to 2017; two studies were reported in Australia [12,13], one Romania [14], ten USA [15,16,17,18,19,20,21,22,23,24], one Argentina [1], four Netherlands [25,26,27,28], two Spain [8,11], one Brazil [29], one China [30], one UK [31], one Croatia [2], four Iran [9,32,33,34], one North Africa/France [35], one Germany/USA [36], two Greece [37,38], one Sweden/Austria [39], two Germany [40,41], five Italy [5,42,43,44,45], one Russia [46], one Germany/Poland [47], one Norway/Sweden [48] and two Sweden [49,50] (Table I). Fifteen studies were case-control and 30 studies were cross-sectional studies.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…Fifteen studies were case-control and 30 studies were cross-sectional studies. Twenty-four studies did polymerase chain reaction (PCR) [1,2,12,14,19,20,21,25,28,29,31,32,35,36,37,39,40,41,42,43,44,46,47,49,50], 2 in situ hybridization (ISH) [15,18], 3 serology [16,48,24], 7 nested PCR [5,8,11,26,27,34,43], one loop-mediated isothermal amplification assay (LAMP)/PCR [30], 4 multiplex serology [17,22,38,45], 2 immunohistochemistry (IHC) [9,33] Meta-analysis Figure 2 shows the incidence of number of HPVs in the BCC patients and controls. Some studies reported this incidence in the BCC patients and controls (case-control studies) and other studies only reported in BCC patients (cross-sectional and cohort studies).…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…Four [5,21,22,48], five [23,28,45,49,50], seven [2,21,23,28,45,47,50], two [2,21], six [2,21,23,28,45,50], five [21,23,28,45,50], four [21,23,45,50] and three studies [21,23,45] reported the prevalence of β1-HPV, HPV 5 (β1), HPV 8 (β1), HPV 12 (β1), HPV 20 (β1), HPV 24 (β1), HPV 36 (β1), and HPV 93 (β1) in the BCC patients, respectively. In addition to, two [21,48], four [21,23,45,50], six [21,23,28,45,49,50], three [21,23,…”

Section: Epidermodysplasia Verruciformis-hpv (Ev-hpv)mentioning

confidence: 99%

“…More than 200 HPV types have been described and divided into five major genera: α-, β-, γ-, μ-and ν-papillomavirus [4]. HPVs can be divided into cutaneous types commonly found in common warts, mucosal types detected in genital condylomas and anogenital cancers and epidermodysplasia verruciformis (EV) types [5,6]. EV is a rare genodermatosis associated with infections with specific HPVs belonging to the β genus of HPV [7].…”

Section: Introductionmentioning

confidence: 99%

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Human papilloma virus infection in basal cell carcinoma of the skin: a systematic review and meta-analysis study

Ramezani¹,

Sadeghi²

2017

pjp

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Human papillomaviruses (HPVs) are a large and ubiquitous group of viruses that some of them have been suggested as a co-factor in the development of non-melanoma skin cancers. The aim of this meta-analysis study was to evaluate HPVs' prevalence in basal cell carcinoma (BCC) of the skin and the risk of them in the BCC patients compared with the healthy controls. Five databases were searched from January 1980 to February 2017. A random-effects meta-analysis was done with the event rate (ER) for the prevalence of HPVs and odds ratio (OR) for estimation of the incidence of HPVs. Out of 1087 studies, 45 studies were included in the review. The pooled analysis demonstrated that the incidence of γ-HPV was effective in the BCC patients compared with the healthy controls [OR = 1.97; 95% CI: 1.52-2.55; p < 0.00001], but not for α-HPV, β-HPV and epidermodysplasia verruciformis (EV)-HPV (p > 0.05). The pooled ER of incidence of β1-HPV in the BCC patients was 33.3% and for β2-HPV in BCC patients was 44.2%. In conclusion, this meta-analysis showed that probably the risk of γ-HPV was more on BCC patients and also the rate of γ-HPV was higher than α-, β-and EV-HPVs in the BCC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of Studiesmentioning

confidence: 99%

Section: Characteristics Of Studiesmentioning

confidence: 99%

Section: Epidermodysplasia Verruciformis-hpv (Ev-hpv)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Human papilloma virus infection in basal cell carcinoma of the skin: a systematic review and meta-analysis study

Ramezani¹,

Sadeghi²

2017

pjp

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Association of Human Papillomavirus Vaccine With the Development of Keratinocyte Carcinomas

Nichols

Allen²,

Shareef

et al. 2017

JAMA Dermatol

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IMPORTANCE Keratinocyte carcinomas (KCs), consisting of squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs), are the most common human malignant neoplasms. Several risk factors have been implicated in KC development. For some SCCs, particularly those in immunocompromised patients, human papillomavirus (HPV) may be an important factor. OBJECTIVE To determine whether quadrivalent HPV vaccination would affect the development of KCs in immunocompetent patients with a history of multiple KCs.DESIGN, SETTING, AND PARTICIPANTS Two patients with a history of multiple KCs-a man in his 70s (patient 1) and a woman in her 80s (patient 2)-were treated in a private dermatology practice. Each patient received 3 doses of the quadrivalent HPV vaccine at 0, 2, and 6 months in 2013, and both patients underwent full-body skin examinations at least every 3 months. Biopsy-proven skin cancers were recorded for 16 months (for patient 1) or 13 months (for patient 2) after the first dose of vaccine and then compared with the number of biopsy-proven skin cancers recorded over a similar period before the first dose of vaccine. The period of observation was from October 18, 2011, to June 21, 2014. MAIN OUTCOMES AND MEASURESThe numbers of new SCCs and BCCs after the first dose of the quadrivalent HPV vaccine.RESULTS Patient 1 had a mean of 12 new SCCs and 2.25 new BCCs per year before vaccination. After vaccination, he developed 4.44 SCCs and 0 BCCs per year, a 62.5% reduction in SCCs and a 100% reduction in BCCs. Patient 2 had a mean of 5.5 new SCCs and 0.92 new BCCs per year before vaccination. After vaccination, she developed 1.84 SCCs and 0 BCCs per year, a 66.5% reduction in SCCs and a 100% reduction in BCCs. The quadrivalent HPV vaccine was well tolerated by both patients and had no adverse effects.CONCLUSIONS AND RELEVANCE A reduction of SCCs and BCCs was observed in 2 patients after administration of the quadrivalent HPV vaccine. These findings highlight the possibility that cutaneous SCC development, and perhaps BCC development, may be driven in part by HPV in immunocompetent patients. Human papillomavirus vaccination may represent an efficacious, cost-effective, readily available, and well-tolerated strategy for preventing KCs.

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Presence ofBetapapillomavirusin Kaposi sarcoma lesions

et al. 2014

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Human herpes virus 8 (HHV 8) is recognized as the necessary cause of Kaposi sarcoma (KS) and in the recent past the human papillomavirus (HPV) has been linked to the development of cutaneous basal cell and squamous cell carcinomas. In a cross sectional study investigating Beta-HPV infections in skin lesions, an unexpected occurrence of HPV DNA was found in KS lesions of HIV infected individuals. Of the 18 KS cases included in the study 16 (89%) had HPV DNA detected. The most common Betapapillomavirus types were HPV14 [15 cases (83.3%)], HPV12 [8 cases (44.4%)], and HPV24 [7 cases (39%)]. Multiple Beta-HPV types were detected in 10 (62.5%) of the participants with HPV DNA positive lesions; of these 7 had a CD4+ count below 350 cells/µl and 3 had CD4+ counts above 350 cells/µl. The presence of Beta-HPV DNA in KS lesions is a newly described phenomenon. Further studies to elucidate the role of Beta-HPV in KS need to be conducted as it is possible that HHV 8 may not be the solitary viral carcinogen in KS tumorigenesis.

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Pattern of HPV infection in basal cell carcinoma and in perilesional skin biopsies from immunocompetent patients

Cited by 35 publications

References 33 publications

Human papilloma virus infection in basal cell carcinoma of the skin: a systematic review and meta-analysis study

Human papilloma virus infection in basal cell carcinoma of the skin: a systematic review and meta-analysis study

Association of Human Papillomavirus Vaccine With the Development of Keratinocyte Carcinomas

Presence ofBetapapillomavirusin Kaposi sarcoma lesions

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