Pattern of hospital mortality among diabetic patients in Sudan

Ahmed, Awad Mohamed; Ahmed, Nada A.; Abdella, Mohy Eldin

doi:10.1002/(sici)1528-252x(200003/04)17:2<41::aid-pdi29>3.0.co;2-s

Cited by 16 publications

(19 citation statements)

References 6 publications

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“…Diabetic ketoacidosis, hyperosmolar nonketotic state and hypoglycaemia accounted for almost 40% of the diabetic deaths. This is similar to reports from other Nigerian and African centres (16,18,19) but much different from reports from industrialized countries with rates from these causes of 3-6% (6). The high diabetic death rate from these acute and rather preventable causes is a reflection of the poor state of diabetic care services available.…”

Section: Discussionsupporting

confidence: 71%

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Mortality among Diabetes In-Patients in Port-Harcourt, Nigeria

Unachukwu¹,

Uchenna²,

Young³

2010

Afr J Endocrinol Metab

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Background: Diabetes mellitus is a major cause of mortality and morbidity among in-patients in Nigeria. It may result from the acute metabolic complications or from the inexorable effects of chronic complications in the major organ systems. Objectives: This study was to determine the death rates and causes of death among in-patients with diabetes at an urban tertiary hospital in Port-Harcourt. Materials and Methods: The medical records of patients admitted with diabetes mellitus into the medical wards of the University of Port Harcourt Teaching Hospital from 1995-2004 were reviewed. The sources of data were the ward admission, death registers, death certificates and medical records. The annual and overall fatality rates were calculated from the available data. Results: During the period under review, 6,574 patients were admitted into the medical wards. Out of these, 686 (10.4%) were due to diabetes and its complications. The diabetic patients comprised of 428 (62.4%) males and 258 (37.6%) females giving a M:F ratio of 1.7:1. One hundred and eighteen of the diabetic patients died giving a case fatality of 17.2%. The main causes of death were diabetic ketoacidosis (DKA) (21.2%), diabetic mellitus foot syndrome (DMFS) (19.5%) and renal failure (12.7%). Diabetic emergencies accounted for 39.8% of all deaths. Conclusion: Diabetes mellitus is a significant cause of medical admissions in Port-Harcourt. The case mortality is very high especially from acute metabolic causes. There is a need for improved management of diabetes in Nigeria.

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Section: Discussionsupporting

confidence: 71%

“…Cerebrovascular disease accounted for about 10% of diabetic deaths. DM together with the other components of the metabolic syndrome are major risk factors to cerebrovascular disease (3,7,18). It is also generally known that cerebrovascular disease is a major cause of death among blacks (7,18).…”

Section: Discussionmentioning

confidence: 99%

Mortality among Diabetes In-Patients in Port-Harcourt, Nigeria

Unachukwu¹,

Uchenna²,

Young³

2010

Afr J Endocrinol Metab

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“…These studies also reported the lowest prevalence of MI (0.1% and 0.2%, respectively) of all included studies, although it is impossible to determine whether other cases were missed because of the studies' limited discussions of their review methods. Studies conducted among more narrowly defined populations with risk factors for coronary artery disease, such as diabetic patients who died while in a hospital in Sudan, reported prevalences of AMI that were orders of magnitude larger (10.4%) [18]. Given the heterogeneity among study populations, it is impossible to make geographic comparisons of AMI prevalence across the continent or to determine whether the prevalence of AMI has been increasing in the face of rapid growth of risk factors for ischemic heart disease.…”

Section: Discussionmentioning

confidence: 99%

Acute Myocardial Infarction in Sub-Saharan Africa: The Need for Data

et al. 2014

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BackgroundTrends in the prevalence of acute myocardial infarction in sub-Saharan Africa have not been well described, despite growing recognition of the increasing burden of cardiovascular disease in low- and middle-income countries. The aim of this systematic review was to describe the prevalence of acute myocardial infarction in sub-Saharan Africa.MethodsWe searched PubMed, EMBASE, Global Health Archive, CINAHL, and Web of Science, and conducted reference and citation analyses. Inclusion criteria were: observational studies, studies that reported incidence or prevalence of acute myocardial infarction, studies conducted in sub-Saharan Africa, and studies that defined acute myocardial infarction by EKG changes or elevation of cardiac biomarkers. Studies conducted prior to 1992 were excluded. Two independent reviewers analyzed titles and abstracts, full-texts, and references and citations. These reviewers also performed quality assessment and data extraction. Quality assessment was conducted with a validated scale for observational studies.FindingsOf 2292 records retrieved, seven studies met all inclusion criteria. These studies included a total of 92,378 participants from highly heterogeneous study populations in five different countries. Methodological quality assessment demonstrated scores ranging from 3 to 7 points (on an 8-point scale). Prevalence of acute myocardial infarction ranged from 0.1 to 10.4% among the included studies.InterpretationThere is insufficient population-based data describing the prevalence of acute myocardial infarction in sub-Saharan Africa. Well-designed registries and surveillance studies that capture the broad and diverse population with acute myocardial infarction in sub-Saharan Africa using common diagnostic criteria are critical in order to guide prevention and treatment strategies.RegistrationRegistered in International Prospective Register of Systematic Reviews (PROSPERO) Database #CRD42012003161.

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“…In Sudan diabetes is an increasingly important problem, being responsible for 10% of hospital admissions and mortality [3]. Recently, an increase in incidence of DM has been observed especially among urbanized population indicating that diabetes mellitus is emerging as an important health problem [4].…”

Section: Introductionmentioning

confidence: 99%

A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional sudanese plants with anti-diabetic potential

Hilmi

Abushama

Abdalgadir

et al. 2014

BMC Complement Altern Med

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BackgroundDiabetes mellitus is a chronic metabolic disease with life-threatening complications. Despite the enormous progress in conventional medicine and pharmaceutical industry, herbal-based medicines are still a common practice for the treatment of diabetes. This study evaluated ethanolic and aqueous extracts of selected Sudanese plants that are traditionally used to treat diabetes.MethodsExtraction was carried out according to method described by Sukhdev et. al. and the extracts were tested for their glycogen phosphorylase inhibition, Brine shrimp lethality and antioxidant activity using (DPPH) radical scavenging activity and iron chelating activity. Extracts prepared from the leaves of Ambrosia maritima, fruits of Foeniculum vulgare and Ammi visnaga, exudates of Acacia Senegal, and seeds of Sesamum indicum and Nigella sativa.ResultsNigella sativa ethanolic extract showed no toxicity on Brine shrimp Lethality Test, while its aqueous extract was toxic. All other extracts were highly toxic and ethanolic extracts of Foeniculum vulgare exhibited the highest toxicity. All plant extracts with exception of Acacia senegal revealed significant antioxidant activity in DPPH free radical scavenging assay.ConclusionsThese results highly agree with the ethnobotanical uses of these plants as antidiabetic. This study endorses further studies on plants investigated, to determine their potential for type 2 diabetes management. Moreover isolation and identification of active compounds are highly recommended.

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Pattern of hospital mortality among diabetic patients in Sudan

Cited by 16 publications

References 6 publications

Mortality among Diabetes In-Patients in Port-Harcourt, Nigeria

Mortality among Diabetes In-Patients in Port-Harcourt, Nigeria

Acute Myocardial Infarction in Sub-Saharan Africa: The Need for Data

A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional sudanese plants with anti-diabetic potential

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